Search Results

Overview

Uniprot IDP0DPH8
Protein NameTubulin alpha-3D chain
Gene NameTUBA3D
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
124 LVLDRIRKLADLCTG
163 RLSVDYGKKSKLEFA
311 KCDPRHGKYMACCML
326 YRGDVVPKDVNAAIA
336 NAAIATIKTKRTIQF
338 AIATIKTKRTIQFVD
370 VPGGDLAKVQRAVCM
394 AWARLDHKFDLMYAK
401 KFDLMYAKRAFVHWY
60 FSETGAGKHVPRAVF
96 PEQLITGKEDAANNY

Function

Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin

Protein Sequence

10 MRECISIHVG 20 QAGVQIGNAC 30 WELYCLEHGI 40 QPDGQMPSDK 50 TIGGGDDSFN 60 TFFSETGAGK 70 HVPRAVFVDL 80 EPTVVDEVRT 90 GTYRQLFHPE 100 QLITGKEDAA 110 NNYARGHYTI 120 GKEIVDLVLD 130 RIRKLADLCT 140 GLQGFLIFHS 150 FGGGTGSGFA 160 SLLMERLSVD 170 YGKKSKLEFA 180 IYPAPQVSTA 190 VVEPYNSILT 200 THTTLEHSDC 210 AFMVDNEAIY 220 DICRRNLDIE 230 RPTYTNLNRL 240 IGQIVSSITA 250 SLRFDGALNV 260 DLTEFQTNLV 270 PYPRIHFPLA 280 TYAPVISAEK 290 AYHEQLSVAE 300 ITNACFEPAN 310 QMVKCDPRHG 320 KYMACCMLYR 330 GDVVPKDVNA 340 AIATIKTKRT 350 IQFVDWCPTG 360 FKVGINYQPP 370 TVVPGGDLAK 380 VQRAVCMLSN 390 TTAIAEAWAR 400 LDHKFDLMYA 410 KRAFVHWYVG 420 EGMEEGEFSE 430 AREDLAALEK 440 DYEEVGVDSV 450 EAEAEEGEEY

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005929 cilium
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0016787 hydrolase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0000278 mitotic cell cycle

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.