Overview
| Uniprot ID | P0DTE4 |
|---|
| Protein Name | UDP-glucuronosyltransferase 2A1 |
|---|
| Gene Name | UGT2A1 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 45 |
IIIDELIKKEHNVTV |
Function
UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:10359671, PubMed:18719240, PubMed:19022937, PubMed:19858781, PubMed:23288867, PubMed:23756265). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:10359671, PubMed:19858781, PubMed:23756265). Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (testosterone and epitestosterone) and estrogens (estradiol and epiestriol) (PubMed:18719240, PubMed:19022937, PubMed:19858781, PubMed:23288867). Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption (PubMed:23756265). Shows a high affinity to aliphatic odorants such as citronellol as well as olfactory tissue specificity, and therefore may be involved in olfaction (PubMed:10359671). Shows a potential role in detoxification of toxic waste compounds in the amniotic fluid before birth, and air-born chemical after birth (PubMed:19858781)
Protein Sequence
10
MLNNLLLFSL
20
QISLIGTTLG
30
GNVLIWPMEG
40
SHWLNVKIII
50
DELIKKEHNV
60
TVLVASGALF
70
ITPTSNPSLT
80
FEIYKVPFGK
90
ERIEGVIKDF
100
VLTWLENRPS
110
PSTIWRFYQE
120
MAKVIKDFHM
130
VSQEICDGVL
140
KNQQLMAKLK
150
KSKFEVLVSD
160
PVFPCGDIVA
170
LKLGIPFMYS
180
LRFSPASTVE
190
KHCGKVPYPP
200
SYVPAVLSEL
210
TDQMSFTDRI
220
RNFISYHLQD
230
YMFETLWKSW
240
DSYYSKALGG
250
LLLCCPGWSA
260
VADLGSLQPL
270
LPGFKRFSRL
280
SLHCSWDYRL
290
PAGRPTTLCE
300
TMGKAEIWLI
310
RTYWDFEFPR
320
PYLPNFEFVG
330
GLHCKPAKPL
340
PKVLWRYKGK
350
KPATLGNNTQ
360
LFDWIPQNDL
370
LGHPKTKAFI
380
THGGTNGIYE
390
AIYHGVPMVG
400
VPMFADQPDN
410
IAHMKAKGAA
420
VEVNLNTMTS
430
VDLLSALRTV
440
INEPSYKENA
450
MRLSRIHHDQ
460
PVKPLDRAVF
470
WIEFVMRHKG
480
AKHLRVAAHD
490
LTWFQYHSLD
500
VIGFLLVCVT
510
TAIFLVIQCC
520
LFSCQKFGKI
GKKKKRE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Molecular Function |
GO:0015020 |
glucuronosyltransferase activity |
| Biological Process |
GO:0008206 |
bile acid metabolic process |
| Biological Process |
GO:0009608 |
response to symbiont |
| Biological Process |
GO:0007606 |
sensory perception of chemical stimulus |
| Biological Process |
GO:0007608 |
sensory perception of smell |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
Reference
PMID: N/A