Overview
| Uniprot ID | P10074 |
|---|
| Protein Name | Zinc finger and BTB domain-containing protein 48 |
|---|
| Gene Name | ZBTB48 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 18 |
RVLQELNKQREKGQY |
Function
Plays a critical role in transcriptional regulation and chromatin remodeling. Acts as a regulator of telomere length (PubMed:28082411, PubMed:28500257). Directly binds the telomeric double-stranded 5'-TTAGGG-3' repeat (PubMed:28082411, PubMed:28500257). Preferentially binds to telomeres that have a low concentration of shelterin complex and acts as a regulator of telomere length by initiating telomere trimming, a process that prevents the accumulation of aberrantly long telomeres (PubMed:28082411). Also acts as a transcription regulator that binds to promoter regions (PubMed:24382891, PubMed:28500257, PubMed:7969177). Regulates expression of a small subset of genes, including MTFP1 (PubMed:28500257). Acts as a negative regulator of cell proliferation by specifically activating expression of ARF, a tumor suppressor isoform of CDKN2A (PubMed:24382891). Acts as a transcription regulator of CIITA, the major factor regulating MHC class II gene expression (PubMed:39562739). In addition, regulates cellular m6A/m6Am methylation on RNA by facilitating the recruitment of the RNA demethylase, FTO, to target mRNAs (PubMed:39300486)
Protein Sequence
10
MDGSFVQHSV
20
RVLQELNKQR
30
EKGQYCDATL
40
DVGGLVFKAH
50
WSVLACCSHF
60
FQSLYGDGSG
70
GSVVLPAGFA
80
EIFGLLLDFF
90
YTGHLALTSG
100
NRDQVLLAAR
110
ELRVPEAVEL
120
CQSFKPKTSV
130
GQAAGGQSGL
140
GPPASQNVNS
150
HVKEPAGLEE
160
EEVSRTLGLV
170
PRDQEPRGSH
180
SPQRPQLHSP
190
AQSEGPSSLC
200
GKLKQALKPC
210
PLEDKKPEDC
220
KVPPRPLEAE
230
GAQLQGGSNE
240
WEVVVQVEDD
250
GDGDYMSEPE
260
AVLTRRKSNV
270
IRKPCAAEPA
280
LSAGSLAAEP
290
AENRKGTAVP
300
VECPTCHKKF
310
LSKYYLKVHN
320
RKHTGEKPFE
330
CPKCGKCYFR
340
KENLLEHEAR
350
NCMNRSEQVF
360
TCSVCQETFR
370
RRMELRVHMV
380
SHTGEMPYKC
390
SSCSQQFMQK
400
KDLQSHMIKL
410
HGAPKPHACP
420
TCAKCFLSRT
430
ELQLHEAFKH
440
RGEKLFVCEE
450
CGHRASSRNG
460
LQMHIKAKHR
470
NERPHVCEFC
480
SHAFTQKANL
490
NMHLRTHTGE
500
KPFQCHLCGK
510
TFRTQASLDK
520
HNRTHTGERP
530
FSCEFCEQRF
540
TEKGPLLRHV
550
ASRHQEGRPH
560
FCQICGKTFK
570
AVEQLRVHVR
580
RHKGVRKFEC
590
TECGYKFTRQ
600
AHLRRHMEIH
610
DRVENYNPRQ
620
RKLRNLIIED
630
EKMVVVALQP
640
PAELEVGSAE
650
VIVESLAQGG
660
LASQLPGQRL
670
CAEESFTGPG
680
VLEPSLIITA
AVPEDCDT
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000781 |
chromosome, telomeric region |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Molecular Function |
GO:0003700 |
DNA-binding transcription factor activity |
| Molecular Function |
GO:0003691 |
double-stranded telomeric DNA binding |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0000978 |
RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function |
GO:0000976 |
transcription cis-regulatory region binding |
| Molecular Function |
GO:0008270 |
zinc ion binding |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0045893 |
positive regulation of DNA-templated transcription |
| Biological Process |
GO:0051252 |
regulation of RNA metabolic process |
| Biological Process |
GO:0006357 |
regulation of transcription by RNA polymerase II |
| Biological Process |
GO:0010833 |
telomere maintenance via telomere lengthening |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.