Search Results
Overview
| Uniprot ID | P10109 |
|---|---|
| Protein Name | Adrenodoxin, mitochondrial |
| Gene Name | FDX1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 66 | ARSSSEDKITVHFIN |
Function
Essential for the synthesis of various steroid hormones (PubMed:20547883, PubMed:21636783). Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis (PubMed:20547883, PubMed:21636783). Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage (PubMed:20547883, PubMed:21636783). Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons (By similarity)
Protein Sequence
10
MAAAGGARLL
20
RAASAVLGGP
30
AGRWLHHAGS
40
RAGSSGLLRN
50
RGPGGSAEAS
60
RSLSVSARAR
70
SSSEDKITVH
80
FINRDGETLT
90
TKGKVGDSLL
100
DVVVENNLDI
110
DGFGACEGTL
120
ACSTCHLIFE
130
DHIYEKLDAI
140
TDEENDMLDL
150
AYGLTDRSRL
160
GCQICLTKSM
170
DNMTVRVPET
180
VADARQSIDV
GKTS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0051537 | 2 iron, 2 sulfur cluster binding |
| Molecular Function | GO:0009055 | electron transfer activity |
| Molecular Function | GO:0005506 | iron ion binding |
| Biological Process | GO:0008203 | cholesterol metabolic process |
| Biological Process | GO:0022900 | electron transport chain |
| Biological Process | GO:0042446 | hormone biosynthetic process |
| Biological Process | GO:0140647 | P450-containing electron transport chain |
| Biological Process | GO:0006694 | steroid biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.