Search Results
Overview
| Uniprot ID | P10155 |
|---|---|
| Protein Name | RNA-binding protein RO60 |
| Gene Name | RO60 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 264 | HLLTNHLKSKEVWKA |
Function
RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:18056422, PubMed:26382853). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed:26382853). Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853). May play roles in cilia formation and/or maintenance (By similarity)
Protein Sequence
10
MEESVNQMQP
20
LNEKQIANSQ
30
DGYVWQVTDM
40
NRLHRFLCFG
50
SEGGTYYIKE
60
QKLGLENAEA
70
LIRLIEDGRG
80
CEVIQEIKSF
90
SQEGRTTKQE
100
PMLFALAICS
110
QCSDISTKQA
120
AFKAVSEVCR
130
IPTHLFTFIQ
140
FKKDLKESMK
150
CGMWGRALRK
160
AIADWYNEKG
170
GMALALAVTK
180
YKQRNGWSHK
190
DLLRLSHLKP
200
SSEGLAIVTK
210
YITKGWKEVH
220
ELYKEKALSV
230
ETEKLLKYLE
240
AVEKVKRTRD
250
ELEVIHLIEE
260
HRLVREHLLT
270
NHLKSKEVWK
280
ALLQEMPLTA
290
LLRNLGKMTA
300
NSVLEPGNSE
310
VSLVCEKLCN
320
EKLLKKARIH
330
PFHILIALET
340
YKTGHGLRGK
350
LKWRPDEEIL
360
KALDAAFYKT
370
FKTVEPTGKR
380
FLLAVDVSAS
390
MNQRVLGSIL
400
NASTVAAAMC
410
MVVTRTEKDS
420
YVVAFSDEMV
430
PCPVTTDMTL
440
QQVLMAMSQI
450
PAGGTDCSLP
460
MIWAQKTNTP
470
ADVFIVFTDN
480
ETFAGGVHPA
490
IALREYRKKM
500
DIPAKLIVCG
510
MTSNGFTIAD
520
PDDRGMLDMC
530
GFDTGALDVI
RNFTLDMI
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:1990904 | ribonucleoprotein complex |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0030030 | cell projection organization |
| Biological Process | GO:0035457 | cellular response to interferon-alpha |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0006383 | transcription by RNA polymerase III |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.