Search Results
Overview
| Uniprot ID | P10173 |
|---|---|
| Protein Name | Fumarate hydratase, mitochondrial |
| Gene Name | FH |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 102 | IKAFGILKRAAAEVN |
| 223 | LHDALDAKSREFAQI |
| 232 | REFAQIIKIGRTHTQ |
| 294 | TRIGFAEKVAAKVAA |
Function
Catalyzes the reversible stereospecific interconversion of fumarate to L-malate (PubMed:21498518). Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable)
Protein Sequence
10
MDRALRLLAR
20
SRCLSRVPAS
30
APGPGPGSSP
40
SGVSRLLLRP
50
PNAARMASQN
60
SFRIEYDTFG
70
ELKVPNDKYY
80
GAQTVRSTMN
90
FKIGGVTERM
100
PIPVIKAFGI
110
LKRAAAEVNQ
120
DYGLDPKIAN
130
AIMKAADEVA
140
EGKLNDHFPL
150
VVWQTGSGTQ
160
TNMNVNEVIS
170
NRAIEMLGGE
180
LGSKKPVHPN
190
DHVNKSQSSN
200
DTFPTAMHIA
210
AAVEVHEALL
220
PGLQKLHDAL
230
DAKSREFAQI
240
IKIGRTHTQD
250
AVPLTLGQEF
260
SGYVQQVKYA
270
ITRIKAAMPR
280
IYELAAGGTA
290
VGTGLNTRIG
300
FAEKVAAKVA
310
ALTGLPFVTA
320
PNKFEALAAH
330
DALVELSGAM
340
NTTACSLMKI
350
ANDIRFLGSG
360
PRSGLGELIL
370
PENEPGSSIM
380
PGKVNPTQCE
390
ALTMVAAQVM
400
GNHVAVTVGG
410
SNGHFELNVF
420
KPMMIKNVLH
430
SARLLGDAAV
440
SFTENCVVGI
450
QANTERINKL
460
MNESLMLVTA
470
LNPHIGYDKA
480
AKIAKTAHKN
490
GSTLKATAVE
500
LGYLTAEQFD
510
EWVKPKDMLG
PK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004333 | fumarate hydratase activity |
| Biological Process | GO:0006525 | arginine metabolic process |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0006106 | fumarate metabolic process |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
| Biological Process | GO:2001034 | positive regulation of double-strand break repair via nonhomologous end joining |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
| Biological Process | GO:0000050 | urea cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.