Search Results
Overview
| Uniprot ID | P10398 |
|---|---|
| Protein Name | Serine/threonine-protein kinase A-Raf |
| Gene Name | ARAF |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 292 | ADDKKKVKNLGYRDS |
Function
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Phosphorylates PFKFB2 (PubMed:36402789)
Protein Sequence
10
MEPPRGPPAN
20
GAEPSRAVGT
30
VKVYLPNKQR
40
TVVTVRDGMS
50
VYDSLDKALK
60
VRGLNQDCCV
70
VYRLIKGRKT
80
VTAWDTAIAP
90
LDGEELIVEV
100
LEDVPLTMHN
110
FVRKTFFSLA
120
FCDFCLKFLF
130
HGFRCQTCGY
140
KFHQHCSSKV
150
PTVCVDMSTN
160
RQQFYHSVQD
170
LSGGSRQHEA
180
PSNRPLNELL
190
TPQGPSPRTQ
200
HCDPEHFPFP
210
APANAPLQRI
220
RSTSTPNVHM
230
VSTTAPMDSN
240
LIQLTGQSFS
250
TDAAGSRGGS
260
DGTPRGSPSP
270
ASVSSGRKSP
280
HSKSPAEQRE
290
RKSLADDKKK
300
VKNLGYRDSG
310
YYWEVPPSEV
320
QLLKRIGTGS
330
FGTVFRGRWH
340
GDVAVKVLKV
350
SQPTAEQAQA
360
FKNEMQVLRK
370
TRHVNILLFM
380
GFMTRPGFAI
390
ITQWCEGSSL
400
YHHLHVADTR
410
FDMVQLIDVA
420
RQTAQGMDYL
430
HAKNIIHRDL
440
KSNNIFLHEG
450
LTVKIGDFGL
460
ATVKTRWSGA
470
QPLEQPSGSV
480
LWMAAEVIRM
490
QDPNPYSFQS
500
DVYAYGVVLY
510
ELMTGSLPYS
520
HIGCRDQIIF
530
MVGRGYLSPD
540
LSKISSNCPK
550
AMRRLLSDCL
560
KFQREERPLF
570
PQILATIELL
580
QRSLPKIERS
590
ASEPSLHRTQ
600
ADELPACLLS
AARLVP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004709 | MAP kinase kinase kinase activity |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0000165 | MAPK cascade |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| Biological Process | GO:0036211 | protein modification process |
| Biological Process | GO:0032434 | regulation of proteasomal ubiquitin-dependent protein catabolic process |
| Biological Process | GO:0032006 | regulation of TOR signaling |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.