Overview
| Uniprot ID | P10536 |
|---|
| Protein Name | Ras-related protein Rab-1B |
|---|
| Gene Name | Rab1b |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 122 |
NKLLVGNKSDLTTKK |
Function
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (By similarity). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (By similarity). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (PubMed:1918138). Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (PubMed:23188820)
Protein Sequence
10
MNPEYDYLFK
20
LLLIGDSGVG
30
KSCLLLRFAD
40
DTYTESYIST
50
IGVDFKIRTI
60
ELDGKTIKLQ
70
IWDTAGQERF
80
RTVTSSYYRG
90
AHGIIVVYDV
100
TDQESYANVK
110
QWLQEIDRYA
120
SENVNKLLVG
130
NKSDLTTKKV
140
VDNTTAKEFA
150
DSLGVPFLET
160
SAKNATNVEQ
170
AFMTMAAEIK
180
KRMGPGAASG
190
GERPNLKIDS
200
TPVKSASGGC
C
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0012505 |
endomembrane system |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005793 |
endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component |
GO:0070382 |
exocytic vesicle |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0000139 |
Golgi membrane |
| Cellular Component |
GO:0042470 |
melanosome |
| Cellular Component |
GO:0043025 |
neuronal cell body |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0034045 |
phagophore assembly site membrane |
| Cellular Component |
GO:0098793 |
presynapse |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Biological Process |
GO:0000045 |
autophagosome assembly |
| Biological Process |
GO:0006914 |
autophagy |
| Biological Process |
GO:0016477 |
cell migration |
| Biological Process |
GO:0090110 |
COPII-coated vesicle cargo loading |
| Biological Process |
GO:0042742 |
defense response to bacterium |
| Biological Process |
GO:0006897 |
endocytosis |
| Biological Process |
GO:0006888 |
endoplasmic reticulum to Golgi vesicle-mediated transport |
| Biological Process |
GO:0007030 |
Golgi organization |
| Biological Process |
GO:0030252 |
growth hormone secretion |
| Biological Process |
GO:0006886 |
intracellular protein transport |
| Biological Process |
GO:0032402 |
melanosome transport |
| Biological Process |
GO:1903020 |
positive regulation of glycoprotein metabolic process |
| Biological Process |
GO:0032757 |
positive regulation of interleukin-8 production |
| Biological Process |
GO:0032482 |
Rab protein signal transduction |
| Biological Process |
GO:2000785 |
regulation of autophagosome assembly |
| Biological Process |
GO:0034446 |
substrate adhesion-dependent cell spreading |
| Biological Process |
GO:0047496 |
vesicle transport along microtubule |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.