Search Results
Overview
| Uniprot ID | P10619 |
|---|---|
| Protein Name | Lysosomal protective protein |
| Gene Name | CTSA |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 43 | QRLPGLAKQPSFRQY |
Function
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity (PubMed:1907282). Also functions as an activator of the sialidase NEU1 (PubMed:37205763). This protein is also a carboxypeptidase and can deamidate tachykinins (PubMed:1694176, PubMed:1756715, PubMed:1907282)
Protein Sequence
10
MIRAAPPPLF
20
LLLLLLLLLV
30
SWASRGEAAP
40
DQDEIQRLPG
50
LAKQPSFRQY
60
SGYLKGSGSK
70
HLHYWFVESQ
80
KDPENSPVVL
90
WLNGGPGCSS
100
LDGLLTEHGP
110
FLVQPDGVTL
120
EYNPYSWNLI
130
ANVLYLESPA
140
GVGFSYSDDK
150
FYATNDTEVA
160
QSNFEALQDF
170
FRLFPEYKNN
180
KLFLTGESYA
190
GIYIPTLAVL
200
VMQDPSMNLQ
210
GLAVGNGLSS
220
YEQNDNSLVY
230
FAYYHGLLGN
240
RLWSSLQTHC
250
CSQNKCNFYD
260
NKDLECVTNL
270
QEVARIVGNS
280
GLNIYNLYAP
290
CAGGVPSHFR
300
YEKDTVVVQD
310
LGNIFTRLPL
320
KRMWHQALLR
330
SGDKVRMDPP
340
CTNTTAASTY
350
LNNPYVRKAL
360
NIPEQLPQWD
370
MCNFLVNLQY
380
RRLYRSMNSQ
390
YLKLLSSQKY
400
QILLYNGDVD
410
MACNFMGDEW
420
FVDSLNQKME
430
VQRRPWLVKY
440
GDSGEQIAGF
450
VKEFSHIAFL
460
TIKGAGHMVP
470
TDKPLAAFTM
480
FSRFLNKQPY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0043202 | lysosomal lumen |
| Cellular Component | GO:0005764 | lysosome |
| Cellular Component | GO:0016020 | membrane |
| Molecular Function | GO:0004180 | carboxypeptidase activity |
| Molecular Function | GO:0008047 | enzyme activator activity |
| Molecular Function | GO:0004185 | serine-type carboxypeptidase activity |
| Biological Process | GO:0006886 | intracellular protein transport |
| Biological Process | GO:1904715 | negative regulation of chaperone-mediated autophagy |
| Biological Process | GO:0006508 | proteolysis |
| Biological Process | GO:1904714 | regulation of chaperone-mediated autophagy |
| Biological Process | GO:0031647 | regulation of protein stability |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.