Overview
| Uniprot ID | P10635 |
|---|
| Protein Name | Cytochrome P450 2D6 |
|---|
| Gene Name | CYP2D6 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 283 |
LAEMEKAKGNPESSF |
Function
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:18698000, PubMed:19965576, PubMed:20972997, PubMed:21289075, PubMed:21576599). Catalyzes the epoxidation of double bonds of polyunsaturated fatty acids (PUFA) (PubMed:19965576, PubMed:20972997). Metabolizes endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling (PubMed:18698000, PubMed:21289075). Catalyzes the hydroxylation of carbon-hydrogen bonds. Metabolizes cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis (PubMed:21576599). Catalyzes the oxidative transformations of all-trans retinol to all-trans retinal, a precursor for the active form all-trans-retinoic acid (PubMed:10681376). Also involved in the oxidative metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants
Protein Sequence
10
MGLEALVPLA
20
VIVAIFLLLV
30
DLMHRRQRWA
40
ARYPPGPLPL
50
PGLGNLLHVD
60
FQNTPYCFDQ
70
LRRRFGDVFS
80
LQLAWTPVVV
90
LNGLAAVREA
100
LVTHGEDTAD
110
RPPVPITQIL
120
GFGPRSQGVF
130
LARYGPAWRE
140
QRRFSVSTLR
150
NLGLGKKSLE
160
QWVTEEAACL
170
CAAFANHSGR
180
PFRPNGLLDK
190
AVSNVIASLT
200
CGRRFEYDDP
210
RFLRLLDLAQ
220
EGLKEESGFL
230
REVLNAVPVL
240
LHIPALAGKV
250
LRFQKAFLTQ
260
LDELLTEHRM
270
TWDPAQPPRD
280
LTEAFLAEME
290
KAKGNPESSF
300
NDENLRIVVA
310
DLFSAGMVTT
320
STTLAWGLLL
330
MILHPDVQRR
340
VQQEIDDVIG
350
QVRRPEMGDQ
360
AHMPYTTAVI
370
HEVQRFGDIV
380
PLGVTHMTSR
390
DIEVQGFRIP
400
KGTTLITNLS
410
SVLKDEAVWE
420
KPFRFHPEHF
430
LDAQGHFVKP
440
EAFLPFSAGR
450
RACLGEPLAR
460
MELFLFFTSL
470
LQHFSFSVPT
480
GQPRPSHHGV
490
FAFLVSPSPY
ELCAVPR
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0090350 |
negative regulation of organofluorine metabolic process |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Molecular Function |
GO:0062188 |
anandamide 11,12 epoxidase activity |
| Molecular Function |
GO:0062189 |
anandamide 14,15 epoxidase activity |
| Molecular Function |
GO:0062187 |
anandamide 8,9 epoxidase activity |
| Molecular Function |
GO:0020037 |
heme binding |
| Molecular Function |
GO:0005506 |
iron ion binding |
| Molecular Function |
GO:0004497 |
monooxygenase activity |
| Molecular Function |
GO:0016491 |
oxidoreductase activity |
| Molecular Function |
GO:0016712 |
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Biological Process |
GO:0009822 |
alkaloid catabolic process |
| Biological Process |
GO:0009820 |
alkaloid metabolic process |
| Biological Process |
GO:0019369 |
arachidonate metabolic process |
| Biological Process |
GO:0008203 |
cholesterol metabolic process |
| Biological Process |
GO:0009804 |
coumarin metabolic process |
| Biological Process |
GO:0008210 |
estrogen metabolic process |
| Biological Process |
GO:0033076 |
isoquinoline alkaloid metabolic process |
| Biological Process |
GO:0042759 |
long-chain fatty acid biosynthetic process |
| Biological Process |
GO:0016098 |
monoterpenoid metabolic process |
| Biological Process |
GO:0070989 |
oxidative demethylation |
| Biological Process |
GO:0042572 |
retinol metabolic process |
| Biological Process |
GO:0008202 |
steroid metabolic process |
| Biological Process |
GO:0042178 |
xenobiotic catabolic process |
| Biological Process |
GO:0006805 |
xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.