Search Results
Overview
| Uniprot ID | P10636 |
|---|---|
| Protein Name | Microtubule-associated protein tau |
| Gene Name | MAPT |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 480 | GAAPPGQKGQANATR |
| 491 | NATRIPAKTPPAPKT |
| 497 | AKTPPAPKTPPSSGE |
| 571 | PVPMPDLKNVKSKIG |
| 576 | DLKNVKSKIGSTENL |
| 584 | IGSTENLKHQPGGGK |
| 591 | KHQPGGGKVQIINKK |
| 597 | GKVQIINKKLDLSNV |
| 598 | KVQIINKKLDLSNVQ |
| 607 | DLSNVQSKCGSKDNI |
| 611 | VQSKCGSKDNIKHVP |
| 628 | GSVQIVYKPVDLSKV |
| 634 | YKPVDLSKVTSKCGS |
| 638 | DLSKVTSKCGSLGNI |
| 648 | SLGNIHHKPGGGQVE |
| 657 | GGGQVEVKSEKLDFK |
| 660 | QVEVKSEKLDFKDRV |
| 670 | FKDRVQSKIGSLDNI |
| 686 | HVPGGGNKKIETHKL |
| 692 | NKKIETHKLTFRENA |
| 702 | FRENAKAKTDHGAEI |
| 712 | HGAEIVYKSPVVSGD |
Function
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization
Protein Sequence
10
MAEPRQEFEV
20
MEDHAGTYGL
30
GDRKDQGGYT
40
MHQDQEGDTD
50
AGLKESPLQT
60
PTEDGSEEPG
70
SETSDAKSTP
80
TAEDVTAPLV
90
DEGAPGKQAA
100
AQPHTEIPEG
110
TTAEEAGIGD
120
TPSLEDEAAG
130
HVTQEPESGK
140
VVQEGFLREP
150
GPPGLSHQLM
160
SGMPGAPLLP
170
EGPREATRQP
180
SGTGPEDTEG
190
GRHAPELLKH
200
QLLGDLHQEG
210
PPLKGAGGKE
220
RPGSKEEVDE
230
DRDVDESSPQ
240
DSPPSKASPA
250
QDGRPPQTAA
260
REATSIPGFP
270
AEGAIPLPVD
280
FLSKVSTEIP
290
ASEPDGPSVG
300
RAKGQDAPLE
310
FTFHVEITPN
320
VQKEQAHSEE
330
HLGRAAFPGA
340
PGEGPEARGP
350
SLGEDTKEAD
360
LPEPSEKQPA
370
AAPRGKPVSR
380
VPQLKARMVS
390
KSKDGTGSDD
400
KKAKTSTRSS
410
AKTLKNRPCL
420
SPKHPTPGSS
430
DPLIQPSSPA
440
VCPEPPSSPK
450
YVSSVTSRTG
460
SSGAKEMKLK
470
GADGKTKIAT
480
PRGAAPPGQK
490
GQANATRIPA
500
KTPPAPKTPP
510
SSGEPPKSGD
520
RSGYSSPGSP
530
GTPGSRSRTP
540
SLPTPPTREP
550
KKVAVVRTPP
560
KSPSSAKSRL
570
QTAPVPMPDL
580
KNVKSKIGST
590
ENLKHQPGGG
600
KVQIINKKLD
610
LSNVQSKCGS
620
KDNIKHVPGG
630
GSVQIVYKPV
640
DLSKVTSKCG
650
SLGNIHHKPG
660
GGQVEVKSEK
670
LDFKDRVQSK
680
IGSLDNITHV
690
PGGGNKKIET
700
HKLTFRENAK
710
AKTDHGAEIV
720
YKSPVVSGDT
730
SPRHLSNVSS
740
TGSIDMVDSP
750
QLATLADEVS
ASLAKQGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030673 | axolemma |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:1904115 | axon cytoplasm |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0043197 | dendritic spine |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0097386 | glial cell projection |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0044304 | main axon |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0097418 | neurofibrillary tangle |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0034399 | nuclear periphery |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0036477 | somatodendritic compartment |
| Cellular Component | GO:0045298 | tubulin complex |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0034185 | apolipoprotein binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0034452 | dynactin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0004857 | enzyme inhibitor activity |
| Molecular Function | GO:0099077 | histone-dependent DNA binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0071813 | lipoprotein particle binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0099609 | microtubule lateral binding |
| Molecular Function | GO:0003680 | minor groove of adenine-thymine-rich DNA binding |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Molecular Function | GO:1902936 | phosphatidylinositol bisphosphate binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0051721 | protein phosphatase 2A binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0043565 | sequence-specific DNA binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0048143 | astrocyte activation |
| Biological Process | GO:0061564 | axon development |
| Biological Process | GO:0098930 | axonal transport |
| Biological Process | GO:0019896 | axonal transport of mitochondrion |
| Biological Process | GO:0007267 | cell-cell signaling |
| Biological Process | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus |
| Biological Process | GO:0034605 | cellular response to heat |
| Biological Process | GO:1990090 | cellular response to nerve growth factor stimulus |
| Biological Process | GO:0034614 | cellular response to reactive oxygen species |
| Biological Process | GO:0021954 | central nervous system neuron development |
| Biological Process | GO:0031122 | cytoplasmic microtubule organization |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0048699 | generation of neurons |
| Biological Process | GO:0048312 | intracellular distribution of mitochondria |
| Biological Process | GO:0007611 | learning or memory |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0001774 | microglial cell activation |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0046785 | microtubule polymerization |
| Biological Process | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0090258 | negative regulation of mitochondrial fission |
| Biological Process | GO:0010917 | negative regulation of mitochondrial membrane potential |
| Biological Process | GO:1902988 | neurofibrillary tangle assembly |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0072386 | plus-end-directed organelle transport along microtubule |
| Biological Process | GO:0045773 | positive regulation of axon extension |
| Biological Process | GO:0031116 | positive regulation of microtubule polymerization |
| Biological Process | GO:1903829 | positive regulation of protein localization |
| Biological Process | GO:1902474 | positive regulation of protein localization to synapse |
| Biological Process | GO:0032930 | positive regulation of superoxide anion generation |
| Biological Process | GO:0051260 | protein homooligomerization |
| Biological Process | GO:0051258 | protein polymerization |
| Biological Process | GO:0010506 | regulation of autophagy |
| Biological Process | GO:0050848 | regulation of calcium-mediated signaling |
| Biological Process | GO:1900034 | regulation of cellular response to heat |
| Biological Process | GO:0033044 | regulation of chromosome organization |
| Biological Process | GO:1900452 | regulation of long-term synaptic depression |
| Biological Process | GO:0070507 | regulation of microtubule cytoskeleton organization |
| Biological Process | GO:0031113 | regulation of microtubule polymerization |
| Biological Process | GO:0031110 | regulation of microtubule polymerization or depolymerization |
| Biological Process | GO:0060632 | regulation of microtubule-based movement |
| Biological Process | GO:0090140 | regulation of mitochondrial fission |
| Biological Process | GO:0048167 | regulation of synaptic plasticity |
| Biological Process | GO:0010288 | response to lead ion |
| Biological Process | GO:0016072 | rRNA metabolic process |
| Biological Process | GO:0034063 | stress granule assembly |
| Biological Process | GO:0097435 | supramolecular fiber organization |
| Biological Process | GO:0007416 | synapse assembly |
| Biological Process | GO:0050808 | synapse organization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.