Search Results
Overview
| Uniprot ID | P10637 |
|---|---|
| Protein Name | Microtubule-associated protein tau |
| Gene Name | Mapt |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 322 | PSVGKGTKEASLQEP |
| 551 | DLKNVRSKIGSTENL |
Function
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization
Protein Sequence
10
MADPRQEFDT
20
MEDHAGDYTL
30
LQDQEGDMDH
40
GLKESPPQPP
50
ADDGAEEPGS
60
ETSDAKSTPT
70
AEDVTAPLVD
80
ERAPDKQAAA
90
QPHTEIPEGI
100
TAEEAGIGDT
110
PNQEDQAAGH
120
VTQGRREGQA
130
PDLGTSDWTR
140
QQVSSMSGAP
150
LLPQGLREAT
160
CQPSGTRPED
170
IEKSHPASEL
180
LRRGPPQKEG
190
WGQDRLGSEE
200
EVDEDLTVDE
210
SSQDSPPSQA
220
SLTPGRAAPQ
230
AGSGSVCGET
240
ASVPGLPTEG
250
SVPLPADFFS
260
KVSAETQASQ
270
PEGPGTGPME
280
EGHEAAPEFT
290
FHVEIKASTP
300
KEQDLEGATV
310
VGVPGEEQKA
320
QTQGPSVGKG
330
TKEASLQEPP
340
GKQPAAGLPG
350
RPVSRVPQLK
360
ARVASKDRTG
370
NDEKKAKTST
380
PSCAKAPSHR
390
PCLSPTRPTL
400
GSSDPLIKPS
410
SPAVSPEPAT
420
SPKHVSSVTP
430
RNGSPGTKQM
440
KLKGADGKTG
450
AKIATPRGAA
460
SPAQKGTSNA
470
TRIPAKTTPS
480
PKTPPGSGEP
490
PKSGERSGYS
500
SPGSPGTPGS
510
RSRTPSLPTP
520
PTREPKKVAV
530
VRTPPKSPSA
540
SKSRLQTAPV
550
PMPDLKNVRS
560
KIGSTENLKH
570
QPGGGKVQII
580
NKKLDLSNVQ
590
SKCGSKDNIK
600
HVPGGGSVQI
610
VYKPVDLSKV
620
TSKCGSLGNI
630
HHKPGGGQVE
640
VKSEKLDFKD
650
RVQSKIGSLD
660
NITHVPGGGN
670
KKIETHKLTF
680
RENAKAKTDH
690
GAEIVYKSPV
700
VSGDTSPRHL
710
SNVSSTGSID
720
MVDSPQLATL
730
ADEVSASLAK
QGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030673 | axolemma |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0036477 | somatodendritic compartment |
| Cellular Component | GO:0045298 | tubulin complex |
| Molecular Function | GO:0034185 | apolipoprotein binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0004857 | enzyme inhibitor activity |
| Molecular Function | GO:0031072 | heat shock protein binding |
| Molecular Function | GO:0051879 | Hsp90 protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0071813 | lipoprotein particle binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0099609 | microtubule lateral binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0051721 | protein phosphatase 2A binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0007628 | adult walking behavior |
| Biological Process | GO:1990000 | amyloid fibril formation |
| Biological Process | GO:0008088 | axo-dendritic transport |
| Biological Process | GO:0048675 | axon extension |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0048312 | intracellular distribution of mitochondria |
| Biological Process | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress |
| Biological Process | GO:0007611 | learning or memory |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0046785 | microtubule polymerization |
| Biological Process | GO:0047497 | mitochondrion transport along microtubule |
| Biological Process | GO:0051028 | mRNA transport |
| Biological Process | GO:1903748 | negative regulation of establishment of protein localization to mitochondrion |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0032387 | negative regulation of intracellular transport |
| Biological Process | GO:0090258 | negative regulation of mitochondrial fission |
| Biological Process | GO:0010917 | negative regulation of mitochondrial membrane potential |
| Biological Process | GO:1904428 | negative regulation of tubulin deacetylation |
| Biological Process | GO:0001764 | neuron migration |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0045773 | positive regulation of axon extension |
| Biological Process | GO:1900454 | positive regulation of long-term synaptic depression |
| Biological Process | GO:0031116 | positive regulation of microtubule polymerization |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:1903829 | positive regulation of protein localization |
| Biological Process | GO:1902474 | positive regulation of protein localization to synapse |
| Biological Process | GO:0032930 | positive regulation of superoxide anion generation |
| Biological Process | GO:0051260 | protein homooligomerization |
| Biological Process | GO:0051258 | protein polymerization |
| Biological Process | GO:0010506 | regulation of autophagy |
| Biological Process | GO:0050848 | regulation of calcium-mediated signaling |
| Biological Process | GO:1900034 | regulation of cellular response to heat |
| Biological Process | GO:0070507 | regulation of microtubule cytoskeleton organization |
| Biological Process | GO:0031110 | regulation of microtubule polymerization or depolymerization |
| Biological Process | GO:0060632 | regulation of microtubule-based movement |
| Biological Process | GO:0010288 | response to lead ion |
| Biological Process | GO:0007584 | response to nutrient |
| Biological Process | GO:0097435 | supramolecular fiber organization |
| Biological Process | GO:0007416 | synapse assembly |
| Biological Process | GO:0050808 | synapse organization |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0044295 | axonal growth cone |
| Cellular Component | GO:0005930 | axoneme |
| Cellular Component | GO:0044297 | cell body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0036464 | cytoplasmic ribonucleoprotein granule |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0097386 | glial cell projection |
| Cellular Component | GO:0030426 | growth cone |
| Cellular Component | GO:0044304 | main axon |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0097418 | neurofibrillary tangle |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0034399 | nuclear periphery |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.