Search Results
Overview
| Uniprot ID | P10644 |
|---|---|
| Protein Name | cAMP-dependent protein kinase type I-alpha regulatory subunit |
| Gene Name | PRKAR1A |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 134 | ALAKAIEKNVLFSHL |
| 261 | SILESLDKWERLTVA |
| 70 | KQIQNLQKAGTRTDS |
| 92 | PPPNPVVKGRRRRGA |
Function
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells
Protein Sequence
10
MESGSTAASE
20
EARSLRECEL
30
YVQKHNIQAL
40
LKDSIVQLCT
50
ARPERPMAFL
60
REYFERLEKE
70
EAKQIQNLQK
80
AGTRTDSRED
90
EISPPPPNPV
100
VKGRRRRGAI
110
SAEVYTEEDA
120
ASYVRKVIPK
130
DYKTMAALAK
140
AIEKNVLFSH
150
LDDNERSDIF
160
DAMFSVSFIA
170
GETVIQQGDE
180
GDNFYVIDQG
190
ETDVYVNNEW
200
ATSVGEGGSF
210
GELALIYGTP
220
RAATVKAKTN
230
VKLWGIDRDS
240
YRRILMGSTL
250
RKRKMYEEFL
260
SKVSILESLD
270
KWERLTVADA
280
LEPVQFEDGQ
290
KIVVQGEPGD
300
EFFIILEGSA
310
AVLQRRSENE
320
EFVEVGRLGP
330
SDYFGEIALL
340
MNRPRAATVV
350
ARGPLKCVKL
360
DRPRFERVLG
370
PCSDILKRNI
380
QQYNSFVSLS
V
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005952 | cAMP-dependent protein kinase complex |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0097546 | ciliary base |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005771 | multivesicular body |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0031588 | nucleotide-activated protein kinase complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0044853 | plasma membrane raft |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0120212 | sperm head-tail coupling apparatus |
| Molecular Function | GO:0030552 | cAMP binding |
| Molecular Function | GO:0004862 | cAMP-dependent protein kinase inhibitor activity |
| Molecular Function | GO:0008603 | cAMP-dependent protein kinase regulator activity |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Molecular Function | GO:0034236 | protein kinase A catalytic subunit binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0034199 | activation of protein kinase A activity |
| Biological Process | GO:0007189 | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0071377 | cellular response to glucagon stimulus |
| Biological Process | GO:0007268 | chemical synaptic transmission |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0046007 | negative regulation of activated T cell proliferation |
| Biological Process | GO:0141162 | negative regulation of cAMP/PKA signal transduction |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0002862 | negative regulation of inflammatory response to antigenic stimulus |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0003091 | renal water homeostasis |
| Biological Process | GO:0097700 | vascular endothelial cell response to laminar fluid shear stress |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.