Overview
| Uniprot ID | P10668 |
|---|
| Protein Name | Cofilin-1 |
|---|
| Gene Name | CFL1 |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 114 |
ECAPLKSKMIYASSK |
| 121 |
KMIYASSKDAIKKKL |
| 132 |
KKKLTGIKHELQANC |
| 144 |
ANCYEEVKDRCTLAE |
| 19 |
IKVFNDMKVRKSSTP |
| 22 |
FNDMKVRKSSTPEEV |
| 30 |
SSTPEEVKKRKKAVL |
| 34 |
EEVKKRKKAVLFCLS |
| 44 |
LFCLSEDKKNIILEE |
| 45 |
FCLSEDKKNIILEEG |
| 78 |
FVKMLPDKDCRYALY |
| 92 |
YDATYETKESKKEDL |
Function
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity (PubMed:6509022, PubMed:9078368). In conjunction with the subcortical maternal complex (SCMC), plays an essential role for zygotes to progress beyond the first embryonic cell divisions via regulation of actin dynamics (PubMed:9078368). Required for the centralization of the mitotic spindle and symmetric division of zygotes (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization in epithelial cells (By similarity). Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (By similarity). Required for neural tube morphogenesis and neural crest cell migration (By similarity)
Protein Sequence
10
MASGVAVSDG
20
VIKVFNDMKV
30
RKSSTPEEVK
40
KRKKAVLFCL
50
SEDKKNIILE
60
EGKEILVGDV
70
GQTVDDPYAT
80
FVKMLPDKDC
90
RYALYDATYE
100
TKESKKEDLV
110
FIFWAPECAP
120
LKSKMIYASS
130
KDAIKKKLTG
140
IKHELQANCY
150
EEVKDRCTLA
160
EKLGGSAVIS
LEGKPL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0015629 |
actin cytoskeleton |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0030426 |
growth cone |
| Cellular Component |
GO:0030027 |
lamellipodium |
| Cellular Component |
GO:0031258 |
lamellipodium membrane |
| Cellular Component |
GO:0016363 |
nuclear matrix |
| Cellular Component |
GO:0032587 |
ruffle membrane |
| Molecular Function |
GO:0051015 |
actin filament binding |
| Biological Process |
GO:0030043 |
actin filament fragmentation |
| Biological Process |
GO:0007015 |
actin filament organization |
| Biological Process |
GO:0051014 |
actin filament severing |
| Biological Process |
GO:0051293 |
establishment of spindle localization |
| Biological Process |
GO:0000281 |
mitotic cytokinesis |
| Biological Process |
GO:0040019 |
positive regulation of embryonic development |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.