Search Results
Overview
| Uniprot ID | P10687 |
|---|---|
| Protein Name | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 |
| Gene Name | Plcb1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1011 | KLIDLKDKQQQQLLN |
| 160 | EKAYTKLKLQVTPEG |
| 286 | EPNSSLAKKGQMSVD |
Function
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors. Regulates the function of the endothelial barrier
Protein Sequence
10
MAGAQPGVHA
20
LQLKPVCVSD
30
SLKKGTKFVK
40
WDDDSTIVTP
50
IILRTDPQGF
60
FFYWTDQNKE
70
TELLDLSLVK
80
DARCGKHAKA
90
PKDPKLRELL
100
DVGNIGHLEQ
110
RMITVVYGPD
120
LVNISHLNLV
130
AFQEEVAKEW
140
TNEVFSLATN
150
LLAQNMSRDA
160
FLEKAYTKLK
170
LQVTPEGRIP
180
LKNIYRLFSA
190
DRKRVETALE
200
ACSLPSSRND
210
SIPQEDFTPD
220
VYRVFLNNLC
230
PRPEIDNIFS
240
EFGAKSKPYL
250
TVDQMMDFIN
260
LKQRDPRLNE
270
ILYPPLKQEQ
280
VQVLIEKYEP
290
NSSLAKKGQM
300
SVDGFMRYLS
310
GEENGVVSPE
320
KLDLNEDMSQ
330
PLSHYFINSS
340
HNTYLTAGQL
350
AGNSSVEMYR
360
QVLLSGCRCV
370
ELDCWKGRTA
380
EEEPVITHGF
390
TMTTEISFKE
400
VIEAIAECAF
410
KTSPFPILLS
420
FENHVDSPKQ
430
QAKMAEYCRL
440
IFGDALLMEP
450
LEKYPLESGV
460
PLPSPMDLMY
470
KILVKNKKKS
480
HKSSEGSGKK
490
KLSEQASNTY
500
SDSSSVFEPS
510
SPGAGEADTE
520
SDDDDDDDDC
530
KKSSMDEGTA
540
GSEAMATEEM
550
SNLVNYIQPV
560
KFESFETSKK
570
RNKSFEMSSF
580
VETKGLEQLT
590
KSPVEFVEYN
600
KMQLSRIYPK
610
GTRVDSSNYM
620
PQLFWNAGCQ
630
MVALNFQTVD
640
LAMQINMGMY
650
EYNGKSGYRL
660
KPEFMRRPDK
670
HFDPFTEGIV
680
DGIVANTLSV
690
KIISGQFLSD
700
KKVGTYVEVD
710
MFGLPVDTRR
720
KAFKTKTSQG
730
NAVNPVWEEE
740
PIVFKKVVLP
750
SLACLRIAAY
760
EEGGKFIGHR
770
ILPVQAIRPG
780
YHYICLRNER
790
NQPLMLPAVF
800
VYIEVKDYVP
810
DTYADVIEAL
820
SNPIRYVNLM
830
EQRAKQLAAL
840
TLEDEEEVKK
850
EADPGETSSE
860
APSETRTTPA
870
ENGVNHTATL
880
APKPPSQAPH
890
SQPAPGSVKA
900
PAKTEDLIQS
910
VLTEVEAQTI
920
EELKQQKSFV
930
KLQKKHYKEM
940
KDLVKRHHKK
950
TTELIKEHTT
960
KYNEIQNDYL
970
RRRAALEKSA
980
KKDSKKKSEP
990
SSPDHGSSAI
1000
EQDLAALDAE
1010
MTQKLIDLKD
1020
KQQQQLLNLR
1030
QEQYYSEKYQ
1040
KREHIKLLIQ
1050
KLTDVAEECQ
1060
NNQLKKLKEI
1070
CEKEKKELKK
1080
KMDKKRQEKI
1090
TEAKSKDKSQ
1100
MEEEKTEMIR
1110
SYIQEVVQYI
1120
KRLEEAQSKR
1130
QEKLVEKHKE
1140
IRQQILDEKP
1150
KLQMELEQEY
1160
QDKFKRLPLE
1170
ILEFVQEAMK
1180
GKVSEDSNHG
1190
SAPPSLASDP
1200
AKVNLKSPSS
1210
EEVQGENAGR
EFDTPL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Biological Process | GO:2000344 | positive regulation of acrosome reaction |
| Biological Process | GO:0048639 | positive regulation of developmental growth |
| Biological Process | GO:0045893 | positive regulation of DNA-templated transcription |
| Biological Process | GO:0040019 | positive regulation of embryonic development |
| Biological Process | GO:1900087 | positive regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0010560 | positive regulation of glycoprotein biosynthetic process |
| Biological Process | GO:0032735 | positive regulation of interleukin-12 production |
| Biological Process | GO:0046330 | positive regulation of JNK cascade |
| Biological Process | GO:0045663 | positive regulation of myoblast differentiation |
| Biological Process | GO:0099170 | postsynaptic modulation of chemical synaptic transmission |
| Biological Process | GO:1903140 | regulation of establishment of endothelial barrier |
| Biological Process | GO:0080154 | regulation of fertilization |
| Biological Process | GO:0008277 | regulation of G protein-coupled receptor signaling pathway |
| Biological Process | GO:0099178 | regulation of retrograde trans-synaptic signaling by endocanabinoid |
| Biological Process | GO:0051209 | release of sequestered calcium ion into cytosol |
| Biological Process | GO:0034284 | response to monosaccharide |
| Biological Process | GO:0043434 | response to peptide hormone |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0031965 | nuclear membrane |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0005096 | GTPase activator activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0005521 | lamin binding |
| Molecular Function | GO:0120548 | phosphatidylinositol phospholipase C activity |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Molecular Function | GO:0004435 | phosphatidylinositol-4,5-bisphosphate phospholipase C activity |
| Biological Process | GO:0060466 | activation of meiosis involved in egg activation |
| Biological Process | GO:1902618 | cellular response to fluoride |
| Biological Process | GO:1905631 | cellular response to glyceraldehyde |
| Biological Process | GO:1904637 | cellular response to ionomycin |
| Biological Process | GO:1904117 | cellular response to vasopressin |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0045444 | fat cell differentiation |
| Biological Process | GO:0007213 | G protein-coupled acetylcholine receptor signaling pathway |
| Biological Process | GO:0007186 | G protein-coupled receptor signaling pathway |
| Biological Process | GO:0000086 | G2/M transition of mitotic cell cycle |
| Biological Process | GO:0007215 | glutamate receptor signaling pathway |
| Biological Process | GO:0032957 | inositol trisphosphate metabolic process |
| Biological Process | GO:0048009 | insulin-like growth factor receptor signaling pathway |
| Biological Process | GO:0070498 | interleukin-1-mediated signaling pathway |
| Biological Process | GO:0035722 | interleukin-12-mediated signaling pathway |
| Biological Process | GO:0035723 | interleukin-15-mediated signaling pathway |
| Biological Process | GO:0007612 | learning |
| Biological Process | GO:0007613 | memory |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
| Biological Process | GO:2000438 | negative regulation of monocyte extravasation |
| Biological Process | GO:0031161 | phosphatidylinositol catabolic process |
| Biological Process | GO:0046488 | phosphatidylinositol metabolic process |
| Biological Process | GO:0048015 | phosphatidylinositol-mediated signaling |
| Biological Process | GO:0007207 | phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway |
| Biological Process | GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.