Overview
| Uniprot ID | P10719 |
|---|
| Protein Name | ATP synthase F(1) complex catalytic subunit beta, mitochondrial |
|---|
| Gene Name | Atp5f1b |
|---|
| Organism | Rattus norvegicus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 124 |
EGLVRGQKVLDSGAP |
| 198 |
DLLAPYAKGGKIGLF |
| 201 |
APYAKGGKIGLFGGA |
| 426 |
DVARGVQKILQDYKS |
| 480 |
VFTGHMGKLVPLKET |
| 485 |
MGKLVPLKETIKGFQ |
| 522 |
EAVAKADKLAEEHGS |
Function
Catalytic subunit beta, of the soluble F(1) head domain within the mitochondrial ATP synthase complex (F(1)F(0) ATP synthase or complex V) that produces ATP from ADP and phosphate inorganique in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain (PubMed:2531579). With the non-catalytic subunit alpha (ATP5F1A), forms the catalytic core in the F(1) domain. ATP synthase complex consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
Protein Sequence
10
MLSLVGRVAS
20
ASASGALRGL
30
NPLAALPQAH
40
LLLRTAPAGV
50
HPARDYAAQS
60
SAAPKAGTAT
70
GQIVAVIGAV
80
VDVQFDEGLP
90
PILNALEVQG
100
RESRLVLEVA
110
QHLGESTVRT
120
IAMDGTEGLV
130
RGQKVLDSGA
140
PIKIPVGPET
150
LGRIMNVIGE
160
PIDERGPIKT
170
KQFAPIHAEA
180
PEFIEMSVEQ
190
EILVTGIKVV
200
DLLAPYAKGG
210
KIGLFGGAGV
220
GKTVLIMELI
230
NNVAKAHGGY
240
SVFAGVGERT
250
REGNDLYHEM
260
IESGVINLKD
270
ATSKVALVYG
280
QMNEPPGARA
290
RVALTGLTVA
300
EYFRDQEGQD
310
VLLFIDNIFR
320
FTQAGSEVSA
330
LLGRIPSAVG
340
YQPTLATDMG
350
TMQERITTTK
360
KGSITSVQAI
370
YVPADDLTDP
380
APATTFAHLD
390
ATTVLSRAIA
400
ELGIYPAVDP
410
LDSTSRIMDP
420
NIVGSEHYDV
430
ARGVQKILQD
440
YKSLQDIIAI
450
LGMDELSEED
460
KLTVSRARKI
470
QRFLSQPFQV
480
AEVFTGHMGK
490
LVPLKETIKG
500
FQQILAGDYD
510
HLPEQAFYMV
520
GPIEEAVAKA
DKLAEEHGS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0045121 |
membrane raft |
| Cellular Component |
GO:0005743 |
mitochondrial inner membrane |
| Cellular Component |
GO:0031966 |
mitochondrial membrane |
| Cellular Component |
GO:0042645 |
mitochondrial nucleoid |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0045259 |
proton-transporting ATP synthase complex |
| Molecular Function |
GO:0043531 |
ADP binding |
| Molecular Function |
GO:0043532 |
angiostatin binding |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0016887 |
ATP hydrolysis activity |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0030228 |
lipoprotein particle receptor activity |
| Molecular Function |
GO:0042288 |
MHC class I protein binding |
| Molecular Function |
GO:0046933 |
proton-transporting ATP synthase activity, rotational mechanism |
| Molecular Function |
GO:0046961 |
proton-transporting ATPase activity, rotational mechanism |
| Biological Process |
GO:0001525 |
angiogenesis |
| Biological Process |
GO:0006754 |
ATP biosynthetic process |
| Biological Process |
GO:0098761 |
cellular response to interleukin-7 |
| Biological Process |
GO:1901653 |
cellular response to peptide |
| Biological Process |
GO:0009631 |
cold acclimation |
| Biological Process |
GO:0006629 |
lipid metabolic process |
| Biological Process |
GO:0001889 |
liver development |
| Biological Process |
GO:0006933 |
negative regulation of cell adhesion involved in substrate-bound cell migration |
| Biological Process |
GO:0043536 |
positive regulation of blood vessel endothelial cell migration |
| Biological Process |
GO:0015986 |
proton motive force-driven ATP synthesis |
| Biological Process |
GO:0042776 |
proton motive force-driven mitochondrial ATP synthesis |
| Biological Process |
GO:1902600 |
proton transmembrane transport |
| Biological Process |
GO:0006898 |
receptor-mediated endocytosis |
| Biological Process |
GO:0051453 |
regulation of intracellular pH |
| Biological Process |
GO:1905242 |
response to 3,3',5-triiodo-L-thyronine |
| Biological Process |
GO:1904643 |
response to curcumin |
| Biological Process |
GO:0010042 |
response to manganese ion |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.