Search Results
Overview
| Uniprot ID | P10760 |
|---|---|
| Protein Name | Adenosylhomocysteinase |
| Gene Name | Ahcy |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 188 | NDSVTKSKFDNLYGC |
| 389 | GVHFLPKKLDEAVAE |
Function
Catalyzes the hydrolysis of S-adenosyl-L-homocysteine to form adenosine and homocysteine (PubMed:11927587). Binds copper ions (By similarity)
Protein Sequence
10
MADKLPYKVA
20
DIGLAAWGRK
30
ALDIAENEMP
40
GLMRMREMYS
50
ASKPLKGARI
60
AGCLHMTVET
70
AVLIETLVAL
80
GAEVRWSSCN
90
IFSTQDHAAA
100
AIAKAGIPVF
110
AWKGETDEEY
120
LWCIEQTLHF
130
KDGPLNMILD
140
DGGDLTNLIH
150
TKHPQLLSGI
160
RGISEETTTG
170
VHNLYKMMAN
180
GILKVPAINV
190
NDSVTKSKFD
200
NLYGCRESLI
210
DGIKRATDVM
220
IAGKVAVVAG
230
YGDVGKGCAQ
240
ALRGFGARVI
250
ITEIDPINAL
260
QAAMEGYEVT
270
TMDEACKEGN
280
IFVTTTGCVD
290
IILGRHFEQM
300
KDDAIVCNIG
310
HFDVEIDVKW
320
LNENAVEKVN
330
IKPQVDRYLL
340
KNGHRIILLA
350
EGRLVNLGCA
360
MGHPSFVMSN
370
SFTNQVMAQI
380
ELWTHPDKYP
390
VGVHFLPKKL
400
DEAVAEAHLG
410
KLNVKLTKLT
420
EKQAQYLGMP
430
INGPFKPDHY
RY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004013 | adenosylhomocysteinase activity |
| Molecular Function | GO:0098604 | adenosylselenohomocysteinase activity |
| Molecular Function | GO:0030554 | adenyl nucleotide binding |
| Molecular Function | GO:0005507 | copper ion binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051287 | NAD binding |
| Biological Process | GO:0002439 | chronic inflammatory response to antigenic stimulus |
| Biological Process | GO:0042745 | circadian sleep/wake cycle |
| Biological Process | GO:0006730 | one-carbon metabolic process |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0007584 | response to nutrient |
| Biological Process | GO:0019510 | S-adenosylhomocysteine catabolic process |
| Biological Process | GO:0033353 | S-adenosylmethionine cycle |
| Biological Process | GO:0033528 | S-methylmethionine cycle |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.