Search Results

Overview

Uniprot IDP10768
Protein NameS-formylglutathione hydrolase
Gene NameESD
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 LKQISSNKCFGGLQK
186 VLCPWGKKAFSGYLG
200 GTDQSKWKAYDATHL
247 IAACTEKKIPVVFRL
4 ****MALKQISSNKC

Function

Serine hydrolase involved in the detoxification of formaldehyde

Protein Sequence

10 MALKQISSNK 20 CFGGLQKVFE 30 HDSVELNCKM 40 KFAVYLPPKA 50 ETGKCPALYW 60 LSGLTCTEQN 70 FISKSGYHQS 80 ASEHGLVVIA 90 PDTSPRGCNI 100 KGEDESWDFG 110 TGAGFYVDAT 120 EDPWKTNYRM 130 YSYVTEELPQ 140 LINANFPVDP 150 QRMSIFGHSM 160 GGHGALICAL 170 KNPGKYKSVS 180 AFAPICNPVL 190 CPWGKKAFSG 200 YLGTDQSKWK 210 AYDATHLVKS 220 YPGSQLDILI 230 DQGKDDQFLL 240 DGQLLPDNFI 250 AACTEKKIPV 260 VFRLQEGYDH 270 SYYFIATFIT 280 DHIRHHAKYL NA

Gene Ontology

Classification GO ID Description
Cellular Component GO:0031410 cytoplasmic vesicle
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0070062 extracellular exosome
Molecular Function GO:0052689 carboxylic ester hydrolase activity
Molecular Function GO:0016788 hydrolase activity, acting on ester bonds
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0047374 methylumbelliferyl-acetate deacetylase activity
Molecular Function GO:0018738 S-formylglutathione hydrolase activity
Biological Process GO:0046294 formaldehyde catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.