Search Results
Overview
| Uniprot ID | P10775 |
|---|---|
| Protein Name | Ribonuclease inhibitor |
| Gene Name | RNH1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 168 | LRATRALKELTVSNN |
| 212 | GLTPANCKDLCGIVA |
| 278 | LCRVLQAKETLKELS |
| 282 | LQAKETLKELSLAGN |
| 290 | ELSLAGNKLGDEGAR |
| 41 | GLTEEHCKDIGSALR |
| 449 | LQALEGSKPGLRVIS |
| 84 | SPTCKIQKLSLQNCS |
Function
Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and angiogenin (ANG). May play a role in redox homeostasis (PubMed:2271559, PubMed:3219361). Required to inhibit the cytotoxic tRNA ribonuclease activity of ANG in the cytoplasm in absence of stress (By similarity). Relocates to the nucleus in response to stress, relieving inhibition of ANG in the cytoplasm, and inhibiting the angiogenic activity of ANG in the nucleus (By similarity)
Protein Sequence
10
MNLDIHCEQL
20
SDARWTELLP
30
LLQQYEVVRL
40
DDCGLTEEHC
50
KDIGSALRAN
60
PSLTELCLRT
70
NELGDAGVHL
80
VLQGLQSPTC
90
KIQKLSLQNC
100
SLTEAGCGVL
110
PSTLRSLPTL
120
RELHLSDNPL
130
GDAGLRLLCE
140
GLLDPQCHLE
150
KLQLEYCRLT
160
AASCEPLASV
170
LRATRALKEL
180
TVSNNDIGEA
190
GARVLGQGLA
200
DSACQLETLR
210
LENCGLTPAN
220
CKDLCGIVAS
230
QASLRELDLG
240
SNGLGDAGIA
250
ELCPGLLSPA
260
SRLKTLWLWE
270
CDITASGCRD
280
LCRVLQAKET
290
LKELSLAGNK
300
LGDEGARLLC
310
ESLLQPGCQL
320
ESLWVKSCSL
330
TAACCQHVSL
340
MLTQNKHLLE
350
LQLSSNKLGD
360
SGIQELCQAL
370
SQPGTTLRVL
380
CLGDCEVTNS
390
GCSSLASLLL
400
ANRSLRELDL
410
SNNCVGDPGV
420
LQLLGSLEQP
430
GCALEQLVLY
440
DTYWTEEVED
450
RLQALEGSKP
GLRVIS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0032311 | angiogenin-PRI complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0008428 | ribonuclease inhibitor activity |
| Biological Process | GO:0016477 | cell migration |
| Biological Process | GO:0045765 | regulation of angiogenesis |
| Biological Process | GO:0034315 | regulation of Arp2/3 complex-mediated actin nucleation |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.