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Overview

Uniprot ID	P10854
Protein Name	Histone H2B type 1-M
Gene Name	H2bc14
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
6	**MPEPTKSAPAPKK

Function

Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling

Protein Sequence

10 MPEPTKSAPA 20 PKKGSKKAVT 30 KAQKKDGKKR 40 KRSRKESYSV 50 YVYKVLKQVH 60 PDTGISSKAM 70 GIMNSFVNDI 80 FERIAGEASR 90 LAHYNKRSTI 100 TSREIQTAVR 110 LLLPGELAKH 120 AVSEGTKAVT KYTSSK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005615	extracellular space
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0000786	nucleosome
Cellular Component	GO:0005634	nucleus
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0046982	protein heterodimerization activity
Molecular Function	GO:0030527	structural constituent of chromatin
Biological Process	GO:0019731	antibacterial humoral response
Biological Process	GO:0061844	antimicrobial humoral immune response mediated by antimicrobial peptide
Biological Process	GO:0006325	chromatin organization
Biological Process	GO:0002227	innate immune response in mucosa

Reference

[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.

[2] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.