Search Results

Overview

Uniprot IDP10860
Protein NameGlutamate dehydrogenase 1, mitochondrial
Gene NameGlud1
OrganismRattus norvegicus

Kla Sites from experimental identification

Position Flanking peptide
183 DVPFGGAKAGVKINP
187 GGAKAGVKINPKNYT
191 AGVKINPKNYTDNEL
200 YTDNELEKITRRFTM
363 GSILGFPKAKVYEGS
390 ASEKQLTKSNAPRVK
399 NAPRVKAKIIAEGAN
457 SYGRLTFKYERDSNY
480 SLERKFGKHGGTIPV
503 RISGASEKDIVHSGL
527 QIMRTAMKYNLGLDL
545 AYVNAIEKVFKVYNE
84 GASIVEDKLVEDLKT
90 DKLVEDLKTRENEEQ

Function

Mitochondrial glutamate dehydrogenase that converts L-glutamate into alpha-ketoglutarate. Plays a key role in glutamine anaplerosis by producing alpha-ketoglutarate, an important intermediate in the tricarboxylic acid cycle (By similarity). Plays a role in insulin homeostasis (By similarity). May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (PubMed:9275181)

Protein Sequence

10 MYRRLGEVLL 20 LSRAGPAALG 30 SAAADSAALL 40 GWARGQPSAV 50 PQPGLTPVAR 60 RHYSEAATDR 70 EDDPNFFKMV 80 EGFFDRGASI 90 VEDKLVEDLK 100 TRENEEQKRN 110 RVRGILRIIK 120 PCNHVLSLSF 130 PIRRDDGSWE 140 VIEGYRAQHS 150 QHRTPCKGGI 160 RYSTDVSVDE 170 VKALASLMTY 180 KCAVVDVPFG 190 GAKAGVKINP 200 KNYTDNELEK 210 ITRRFTMELA 220 KKGFIGPGID 230 VPAPDMSTGE 240 REMSWIADTY 250 ASTIGHYDIN 260 AHACVTGKPI 270 SQGGIHGRIS 280 ATGRGVFHGI 290 ENFINEASYM 300 SILGMTPGLG 310 DKTFVVQGFG 320 NVGLHSMRYL 330 HRFGAKCVGV 340 GESDGSIWNP 350 DGIDPKELED 360 FKLQHGSILG 370 FPKAKVYEGS 380 ILEADCDILI 390 PAASEKQLTK 400 SNAPRVKAKI 410 IAEGANGPTT 420 PEADKIFLER 430 NIMVIPDLYL 440 NAGGVTVSYF 450 EWLKNLNHVS 460 YGRLTFKYER 470 DSNYHLLMSV 480 QESLERKFGK 490 HGGTIPVVPT 500 AEFQDRISGA 510 SEKDIVHSGL 520 AYTMERSARQ 530 IMRTAMKYNL 540 GLDLRTAAYV 550 NAIEKVFKVY NEAGVTFT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0043531 ADP binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0004352 glutamate dehydrogenase (NAD+) activity
Molecular Function GO:0004354 glutamate dehydrogenase (NADP+) activity
Molecular Function GO:0004353 glutamate dehydrogenase [NAD(P)+] activity
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0070728 L-leucine binding
Molecular Function GO:0070403 NAD+ binding
Molecular Function GO:0042803 protein homodimerization activity
Biological Process GO:0021549 cerebellum development
Biological Process GO:0006537 glutamate biosynthetic process
Biological Process GO:0006541 glutamine metabolic process
Biological Process GO:0006538 L-glutamate catabolic process
Biological Process GO:0007616 long-term memory
Biological Process GO:0032024 positive regulation of insulin secretion
Biological Process GO:0010044 response to aluminum ion
Biological Process GO:0072350 tricarboxylic acid metabolic process

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.

[3] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.