Overview
| Uniprot ID | P10916 |
|---|
| Protein Name | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform |
|---|
| Gene Name | MYL2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 91 |
TMFGEKLKGADPEET |
Function
Contractile protein that plays a role in heart development and function (PubMed:23365102, PubMed:32453731). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity)
Protein Sequence
10
MAPKKAKKRA
20
GGANSNVFSM
30
FEQTQIQEFK
40
EAFTIMDQNR
50
DGFIDKNDLR
60
DTFAALGRVN
70
VKNEEIDEMI
80
KEAPGPINFT
90
VFLTMFGEKL
100
KGADPEETIL
110
NAFKVFDPEG
120
KGVLKADYVR
130
EMLTTQAERF
140
SKEEVDQMFA
150
AFPPDVTGNL
160
DYKNLVHIIT
HGEEKD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0031672 |
A band |
| Cellular Component |
GO:0097512 |
cardiac myofibril |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005856 |
cytoskeleton |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0030016 |
myofibril |
| Cellular Component |
GO:0016459 |
myosin complex |
| Cellular Component |
GO:0030017 |
sarcomere |
| Molecular Function |
GO:0003785 |
actin monomer binding |
| Molecular Function |
GO:0005509 |
calcium ion binding |
| Molecular Function |
GO:0032036 |
myosin heavy chain binding |
| Molecular Function |
GO:0008307 |
structural constituent of muscle |
| Biological Process |
GO:0060048 |
cardiac muscle contraction |
| Biological Process |
GO:0055003 |
cardiac myofibril assembly |
| Biological Process |
GO:0060047 |
heart contraction |
| Biological Process |
GO:0007507 |
heart development |
| Biological Process |
GO:0042694 |
muscle cell fate specification |
| Biological Process |
GO:0030308 |
negative regulation of cell growth |
| Biological Process |
GO:0098735 |
positive regulation of the force of heart contraction |
| Biological Process |
GO:0006942 |
regulation of striated muscle contraction |
| Biological Process |
GO:0002026 |
regulation of the force of heart contraction |
| Biological Process |
GO:0055010 |
ventricular cardiac muscle tissue morphogenesis |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.