Search Results
Overview
| Uniprot ID | P10922 |
|---|---|
| Protein Name | Histone H1.0 |
| Gene Name | H1-0 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 164 | AKKPKVVKVKPVKAS |
Function
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex. The histones H1.0 are found in cells that are in terminal stages of differentiation or that have low rates of cell division
Protein Sequence
10
MTENSTSAPA
20
AKPKRAKASK
30
KSTDHPKYSD
40
MIVAAIQAEK
50
NRAGSSRQSI
60
QKYIKSHYKV
70
GENADSQIKL
80
SIKRLVTTGV
90
LKQTKGVGAS
100
GSFRLAKGDE
110
PKRSVAFKKT
120
KKEVKKVATP
130
KKAAKPKKAA
140
SKAPSKKPKA
150
TPVKKAKKKP
160
AATPKKAKKP
170
KVVKVKPVKA
180
SKPKKAKTVK
190
PKAKSSAKRA
SKKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0031507 | heterochromatin formation |
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0016604 | nuclear body |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0017053 | transcription repressor complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0003680 | minor groove of adenine-thymine-rich DNA binding |
| Molecular Function | GO:0031492 | nucleosomal DNA binding |
| Molecular Function | GO:0030527 | structural constituent of chromatin |
| Biological Process | GO:0030261 | chromosome condensation |
| Biological Process | GO:0045910 | negative regulation of DNA recombination |
| Biological Process | GO:0006334 | nucleosome assembly |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.