Search Results
Overview
| Uniprot ID | P11030 |
|---|---|
| Protein Name | Acyl-CoA-binding protein |
| Gene Name | Dbi |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 51 | RPGLLDLKGKAKWDS |
| 55 | LDLKGKAKWDSWNKL |
| 67 | NKLKGTSKENAMKTY |
| 72 | TSKENAMKTYVEKVE |
| 77 | AMKTYVEKVEELKKK |
| 8 | MSQADFDKAAEEVKR |
Function
Binds medium- and long-chain acyl-CoA esters with very high affinity and may function as an intracellular carrier of acyl-CoA esters. It is also able to displace diazepam from the benzodiazepine (BZD) recognition site located on the GABA type A receptor. It is therefore possible that this protein also acts as a neuropeptide to modulate the action of the GABA receptor
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0043292 | contractile muscle fiber |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0097038 | perinuclear endoplasmic reticulum |
| Cellular Component | GO:0032994 | protein-lipid complex |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Molecular Function | GO:0030156 | benzodiazepine receptor binding |
| Molecular Function | GO:0000062 | fatty-acyl-CoA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0036042 | long-chain fatty acyl-CoA binding |
| Biological Process | GO:0001662 | behavioral fear response |
| Biological Process | GO:0031670 | cellular response to nutrient |
| Biological Process | GO:1990708 | conditioned place preference |
| Biological Process | GO:0006631 | fatty acid metabolic process |
| Biological Process | GO:0014009 | glial cell proliferation |
| Biological Process | GO:0001942 | hair follicle development |
| Biological Process | GO:0021670 | lateral ventricle development |
| Biological Process | GO:0007611 | learning or memory |
| Biological Process | GO:0060291 | long-term synaptic potentiation |
| Biological Process | GO:0031999 | negative regulation of fatty acid beta-oxidation |
| Biological Process | GO:0036151 | phosphatidylcholine acyl-chain remodeling |
| Biological Process | GO:0046889 | positive regulation of lipid biosynthetic process |
| Biological Process | GO:2001140 | positive regulation of phospholipid transport |
| Biological Process | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol |
| Biological Process | GO:0032228 | regulation of synaptic transmission, GABAergic |
| Biological Process | GO:0043588 | skin development |
| Biological Process | GO:0006641 | triglyceride metabolic process |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.