Search Results
Overview
| Uniprot ID | P11031 |
|---|---|
| Protein Name | Activated RNA polymerase II transcriptional coactivator p15 |
| Gene Name | Sub1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 29 | EKKLKRKKQAVPEKP |
| 35 | KKQAVPEKPVKKQKP |
| 38 | AVPEKPVKKQKPGET |
Function
General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA)
Protein Sequence
10
MPKSKELVSS
20
SSSGSDSDSE
30
VEKKLKRKKQ
40
AVPEKPVKKQ
50
KPGETSRALA
60
SSKQSSSSRD
70
DNMFQIGKMR
80
YVSVRDFKGK
90
ILIDIREYWM
100
DSEGEMKPGR
110
KGISLNMEQW
120
SQLKEQISDI
DDAVRKL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005667 | transcription regulator complex |
| Molecular Function | GO:0003690 | double-stranded DNA binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0003697 | single-stranded DNA binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0051053 | negative regulation of DNA metabolic process |
| Biological Process | GO:0060261 | positive regulation of transcription initiation by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001111 | RNA polymerase II promoter clearance |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.