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Overview

Uniprot IDP11047
Protein NameLaminin subunit gamma-1
Gene NameLAMC1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1329 KNLLEKGKTEQQTAD
1423 AADATEAKNKAHEAE
1557 KVSDLDRKVSDLENE
788 CAVVPKTKEVVCTNC

Function

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway

Protein Sequence

10 MRGSHRAAPA 20 LRPRGRLWPV 30 LAVLAAAAAA 40 GCAQAAMDEC 50 TDEGGRPQRC 60 MPEFVNAAFN 70 VTVVATNTCG 80 TPPEEYCVQT 90 GVTGVTKSCH 100 LCDAGQPHLQ 110 HGAAFLTDYN 120 NQADTTWWQS 130 QTMLAGVQYP 140 SSINLTLHLG 150 KAFDITYVRL 160 KFHTSRPESF 170 AIYKRTREDG 180 PWIPYQYYSG 190 SCENTYSKAN 200 RGFIRTGGDE 210 QQALCTDEFS 220 DISPLTGGNV 230 AFSTLEGRPS 240 AYNFDNSPVL 250 QEWVTATDIR 260 VTLNRLNTFG 270 DEVFNDPKVL 280 KSYYYAISDF 290 AVGGRCKCNG 300 HASECMKNEF 310 DKLVCNCKHN 320 TYGVDCEKCL 330 PFFNDRPWRR 340 ATAESASECL 350 PCDCNGRSQE 360 CYFDPELYRS 370 TGHGGHCTNC 380 QDNTDGAHCE 390 RCRENFFRLG 400 NNEACSSCHC 410 SPVGSLSTQC 420 DSYGRCSCKP 430 GVMGDKCDRC 440 QPGFHSLTEA 450 GCRPCSCDPS 460 GSIDECNIET 470 GRCVCKDNVE 480 GFNCERCKPG 490 FFNLESSNPR 500 GCTPCFCFGH 510 SSVCTNAVGY 520 SVYSISSTFQ 530 IDEDGWRAEQ 540 RDGSEASLEW 550 SSERQDIAVI 560 SDSYFPRYFI 570 APAKFLGKQV 580 LSYGQNLSFS 590 FRVDRRDTRL 600 SAEDLVLEGA 610 GLRVSVPLIA 620 QGNSYPSETT 630 VKYVFRLHEA 640 TDYPWRPALT 650 PFEFQKLLNN 660 LTSIKIRGTY 670 SERSAGYLDD 680 VTLASARPGP 690 GVPATWVESC 700 TCPVGYGGQF 710 CEMCLSGYRR 720 ETPNLGPYSP 730 CVLCACNGHS 740 ETCDPETGVC 750 NCRDNTAGPH 760 CEKCSDGYYG 770 DSTAGTSSDC 780 QPCPCPGGSS 790 CAVVPKTKEV 800 VCTNCPTGTT 810 GKRCELCDDG 820 YFGDPLGRNG 830 PVRLCRLCQC 840 SDNIDPNAVG 850 NCNRLTGECL 860 KCIYNTAGFY 870 CDRCKDGFFG 880 NPLAPNPADK 890 CKACNCNLYG 900 TMKQQSSCNP 910 VTGQCECLPH 920 VTGQDCGACD 930 PGFYNLQSGQ 940 GCERCDCHAL 950 GSTNGQCDIR 960 TGQCECQPGI 970 TGQHCERCEV 980 NHFGFGPEGC 990 KPCDCHPEGS 1000 LSLQCKDDGR 1010 CECREGFVGN 1020 RCDQCEENYF 1030 YNRSWPGCQE 1040 CPACYRLVKD 1050 KVADHRVKLQ 1060 ELESLIANLG 1070 TGDEMVTDQA 1080 FEDRLKEAER 1090 EVMDLLREAQ 1100 DVKDVDQNLM 1110 DRLQRVNNTL 1120 SSQISRLQNI 1130 RNTIEETGNL 1140 AEQARAHVEN 1150 TERLIEIASR 1160 ELEKAKVAAA 1170 NVSVTQPEST 1180 GDPNNMTLLA 1190 EEARKLAERH 1200 KQEADDIVRV 1210 AKTANDTSTE 1220 AYNLLLRTLA 1230 GENQTAFEIE 1240 ELNRKYEQAK 1250 NISQDLEKQA 1260 ARVHEEAKRA 1270 GDKAVEIYAS 1280 VAQLSPLDSE 1290 TLENEANNIK 1300 MEAENLEQLI 1310 DQKLKDYEDL 1320 REDMRGKELE 1330 VKNLLEKGKT 1340 EQQTADQLLA 1350 RADAAKALAE 1360 EAAKKGRDTL 1370 QEANDILNNL 1380 KDFDRRVNDN 1390 KTAAEEALRK 1400 IPAINQTITE 1410 ANEKTREAQQ 1420 ALGSAAADAT 1430 EAKNKAHEAE 1440 RIASAVQKNA 1450 TSTKAEAERT 1460 FAEVTDLDNE 1470 VNNMLKQLQE 1480 AEKELKRKQD 1490 DADQDMMMAG 1500 MASQAAQEAE 1510 INARKAKNSV 1520 TSLLSIINDL 1530 LEQLGQLDTV 1540 DLNKLNEIEG 1550 TLNKAKDEMK 1560 VSDLDRKVSD 1570 LENEAKKQEA 1580 AIMDYNRDIE 1590 EIMKDIRNLE 1600 DIRKTLPSGC FNTPSIEKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005604 basement membrane
Biological Process GO:0007492 endoderm development
Biological Process GO:0022617 extracellular matrix disassembly
Biological Process GO:0031581 hemidesmosome assembly
Biological Process GO:0035633 maintenance of blood-brain barrier
Biological Process GO:0045785 positive regulation of cell adhesion
Biological Process GO:0050679 positive regulation of epithelial cell proliferation
Biological Process GO:2001046 positive regulation of integrin-mediated signaling pathway
Biological Process GO:0051149 positive regulation of muscle cell differentiation
Biological Process GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:0110011 regulation of basement membrane organization
Biological Process GO:0030155 regulation of cell adhesion
Biological Process GO:0030334 regulation of cell migration
Biological Process GO:0045995 regulation of embryonic development
Biological Process GO:0007165 signal transduction
Biological Process GO:0034446 substrate adhesion-dependent cell spreading
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:0005606 laminin-111 trimer
Cellular Component GO:0005608 laminin-121 trimer
Cellular Component GO:0005607 laminin-211 trimer
Cellular Component GO:0005609 laminin-221 trimer
Cellular Component GO:0005611 laminin-311 trimer
Cellular Component GO:0005612 laminin-321 trimer
Cellular Component GO:0043257 laminin-411 trimer
Cellular Component GO:0043258 laminin-421 trimer
Cellular Component GO:0043259 laminin-511 trimer
Cellular Component GO:0043260 laminin-521 trimer
Molecular Function GO:0005201 extracellular matrix structural constituent
Biological Process GO:0007155 cell adhesion
Biological Process GO:0016477 cell migration

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.