Search Results
Overview
| Uniprot ID | P11047 |
|---|---|
| Protein Name | Laminin subunit gamma-1 |
| Gene Name | LAMC1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1329 | KNLLEKGKTEQQTAD |
| 1423 | AADATEAKNKAHEAE |
| 1557 | KVSDLDRKVSDLENE |
| 788 | CAVVPKTKEVVCTNC |
Function
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. As a subunit of laminin-1 (also known as laminin-111 or EHS laminin), it is involved in the stimulation of agrin-induced receptor clustering through a MuSK-independent pathway
Protein Sequence
10
MRGSHRAAPA
20
LRPRGRLWPV
30
LAVLAAAAAA
40
GCAQAAMDEC
50
TDEGGRPQRC
60
MPEFVNAAFN
70
VTVVATNTCG
80
TPPEEYCVQT
90
GVTGVTKSCH
100
LCDAGQPHLQ
110
HGAAFLTDYN
120
NQADTTWWQS
130
QTMLAGVQYP
140
SSINLTLHLG
150
KAFDITYVRL
160
KFHTSRPESF
170
AIYKRTREDG
180
PWIPYQYYSG
190
SCENTYSKAN
200
RGFIRTGGDE
210
QQALCTDEFS
220
DISPLTGGNV
230
AFSTLEGRPS
240
AYNFDNSPVL
250
QEWVTATDIR
260
VTLNRLNTFG
270
DEVFNDPKVL
280
KSYYYAISDF
290
AVGGRCKCNG
300
HASECMKNEF
310
DKLVCNCKHN
320
TYGVDCEKCL
330
PFFNDRPWRR
340
ATAESASECL
350
PCDCNGRSQE
360
CYFDPELYRS
370
TGHGGHCTNC
380
QDNTDGAHCE
390
RCRENFFRLG
400
NNEACSSCHC
410
SPVGSLSTQC
420
DSYGRCSCKP
430
GVMGDKCDRC
440
QPGFHSLTEA
450
GCRPCSCDPS
460
GSIDECNIET
470
GRCVCKDNVE
480
GFNCERCKPG
490
FFNLESSNPR
500
GCTPCFCFGH
510
SSVCTNAVGY
520
SVYSISSTFQ
530
IDEDGWRAEQ
540
RDGSEASLEW
550
SSERQDIAVI
560
SDSYFPRYFI
570
APAKFLGKQV
580
LSYGQNLSFS
590
FRVDRRDTRL
600
SAEDLVLEGA
610
GLRVSVPLIA
620
QGNSYPSETT
630
VKYVFRLHEA
640
TDYPWRPALT
650
PFEFQKLLNN
660
LTSIKIRGTY
670
SERSAGYLDD
680
VTLASARPGP
690
GVPATWVESC
700
TCPVGYGGQF
710
CEMCLSGYRR
720
ETPNLGPYSP
730
CVLCACNGHS
740
ETCDPETGVC
750
NCRDNTAGPH
760
CEKCSDGYYG
770
DSTAGTSSDC
780
QPCPCPGGSS
790
CAVVPKTKEV
800
VCTNCPTGTT
810
GKRCELCDDG
820
YFGDPLGRNG
830
PVRLCRLCQC
840
SDNIDPNAVG
850
NCNRLTGECL
860
KCIYNTAGFY
870
CDRCKDGFFG
880
NPLAPNPADK
890
CKACNCNLYG
900
TMKQQSSCNP
910
VTGQCECLPH
920
VTGQDCGACD
930
PGFYNLQSGQ
940
GCERCDCHAL
950
GSTNGQCDIR
960
TGQCECQPGI
970
TGQHCERCEV
980
NHFGFGPEGC
990
KPCDCHPEGS
1000
LSLQCKDDGR
1010
CECREGFVGN
1020
RCDQCEENYF
1030
YNRSWPGCQE
1040
CPACYRLVKD
1050
KVADHRVKLQ
1060
ELESLIANLG
1070
TGDEMVTDQA
1080
FEDRLKEAER
1090
EVMDLLREAQ
1100
DVKDVDQNLM
1110
DRLQRVNNTL
1120
SSQISRLQNI
1130
RNTIEETGNL
1140
AEQARAHVEN
1150
TERLIEIASR
1160
ELEKAKVAAA
1170
NVSVTQPEST
1180
GDPNNMTLLA
1190
EEARKLAERH
1200
KQEADDIVRV
1210
AKTANDTSTE
1220
AYNLLLRTLA
1230
GENQTAFEIE
1240
ELNRKYEQAK
1250
NISQDLEKQA
1260
ARVHEEAKRA
1270
GDKAVEIYAS
1280
VAQLSPLDSE
1290
TLENEANNIK
1300
MEAENLEQLI
1310
DQKLKDYEDL
1320
REDMRGKELE
1330
VKNLLEKGKT
1340
EQQTADQLLA
1350
RADAAKALAE
1360
EAAKKGRDTL
1370
QEANDILNNL
1380
KDFDRRVNDN
1390
KTAAEEALRK
1400
IPAINQTITE
1410
ANEKTREAQQ
1420
ALGSAAADAT
1430
EAKNKAHEAE
1440
RIASAVQKNA
1450
TSTKAEAERT
1460
FAEVTDLDNE
1470
VNNMLKQLQE
1480
AEKELKRKQD
1490
DADQDMMMAG
1500
MASQAAQEAE
1510
INARKAKNSV
1520
TSLLSIINDL
1530
LEQLGQLDTV
1540
DLNKLNEIEG
1550
TLNKAKDEMK
1560
VSDLDRKVSD
1570
LENEAKKQEA
1580
AIMDYNRDIE
1590
EIMKDIRNLE
1600
DIRKTLPSGC
FNTPSIEKP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005604 | basement membrane |
| Biological Process | GO:0007492 | endoderm development |
| Biological Process | GO:0022617 | extracellular matrix disassembly |
| Biological Process | GO:0031581 | hemidesmosome assembly |
| Biological Process | GO:0035633 | maintenance of blood-brain barrier |
| Biological Process | GO:0045785 | positive regulation of cell adhesion |
| Biological Process | GO:0050679 | positive regulation of epithelial cell proliferation |
| Biological Process | GO:2001046 | positive regulation of integrin-mediated signaling pathway |
| Biological Process | GO:0051149 | positive regulation of muscle cell differentiation |
| Biological Process | GO:1904395 | positive regulation of skeletal muscle acetylcholine-gated channel clustering |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0110011 | regulation of basement membrane organization |
| Biological Process | GO:0030155 | regulation of cell adhesion |
| Biological Process | GO:0030334 | regulation of cell migration |
| Biological Process | GO:0045995 | regulation of embryonic development |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0034446 | substrate adhesion-dependent cell spreading |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0031012 | extracellular matrix |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0005606 | laminin-111 trimer |
| Cellular Component | GO:0005608 | laminin-121 trimer |
| Cellular Component | GO:0005607 | laminin-211 trimer |
| Cellular Component | GO:0005609 | laminin-221 trimer |
| Cellular Component | GO:0005611 | laminin-311 trimer |
| Cellular Component | GO:0005612 | laminin-321 trimer |
| Cellular Component | GO:0043257 | laminin-411 trimer |
| Cellular Component | GO:0043258 | laminin-421 trimer |
| Cellular Component | GO:0043259 | laminin-511 trimer |
| Cellular Component | GO:0043260 | laminin-521 trimer |
| Molecular Function | GO:0005201 | extracellular matrix structural constituent |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0016477 | cell migration |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.