Search Results

Overview

Uniprot IDP11055
Protein NameMyosin-3
Gene NameMYH3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1588 DEEIEQLKRNYQRTV

Function

Muscle contraction

Protein Sequence

10 MSSDTEMEVF 20 GIAAPFLRKS 30 EKERIEAQNQ 40 PFDAKTYCFV 50 VDSKEEYAKG 60 KIKSSQDGKV 70 TVETEDNRTL 80 VVKPEDVYAM 90 NPPKFDRIED 100 MAMLTHLNEP 110 AVLYNLKDRY 120 TSWMIYTYSG 130 LFCVTVNPYK 140 WLPVYNPEVV 150 EGYRGKKRQE 160 APPHIFSISD 170 NAYQFMLTDR 180 ENQSILITGE 190 SGAGKTVNTK 200 RVIQYFATIA 210 ATGDLAKKKD 220 SKMKGTLEDQ 230 IISANPLLEA 240 FGNAKTVRND 250 NSSRFGKFIR 260 IHFGTTGKLA 270 SADIETYLLE 280 KSRVTFQLKA 290 ERSYHIFYQI 300 LSNKKPELIE 310 LLLITTNPYD 320 YPFISQGEIL 330 VASIDDAEEL 340 LATDSAIDIL 350 GFTPEEKSGL 360 YKLTGAVMHY 370 GNMKFKQKQR 380 EEQAEPDGTE 390 VADKTAYLMG 400 LNSSDLLKAL 410 CFPRVKVGNE 420 YVTKGQTVDQ 430 VHHAVNALSK 440 SVYEKLFLWM 450 VTRINQQLDT 460 KLPRQHFIGV 470 LDIAGFEIFE 480 YNSLEQLCIN 490 FTNEKLQQFF 500 NHHMFVLEQE 510 EYKKEGIEWT 520 FIDFGMDLAA 530 CIELIEKPMG 540 IFSILEEECM 550 FPKATDTSFK 560 NKLYDQHLGK 570 SNNFQKPKVV 580 KGRAEAHFSL 590 IHYAGTVDYS 600 VSGWLEKNKD 610 PLNETVVGLY 620 QKSSNRLLAH 630 LYATFATADA 640 DSGKKKVAKK 650 KGSSFQTVSA 660 LFRENLNKLM 670 SNLRTTHPHF 680 VRCIIPNETK 690 TPGAMEHSLV 700 LHQLRCNGVL 710 EGIRICRKGF 720 PNRILYGDFK 730 QRYRVLNASA 740 IPEGQFIDSK 750 KACEKLLASI 760 DIDHTQYKFG 770 HTKVFFKAGL 780 LGTLEEMRDD 790 RLAKLITRTQ 800 AVCRGFLMRV 810 EFQKMVQRRE 820 SIFCIQYNIR 830 SFMNVKHWPW 840 MKLFFKIKPL 850 LKSAETEKEM 860 ATMKEEFQKT 870 KDELAKSEAK 880 RKELEEKLVT 890 LVQEKNDLQL 900 QVQAESENLL 910 DAEERCDQLI 920 KAKFQLEAKI 930 KEVTERAEDE 940 EEINAELTAK 950 KRKLEDECSE 960 LKKDIDDLEL 970 TLAKVEKEKH 980 ATENKVKNLT 990 EELSGLDETI 1000 AKLTREKKAL 1010 QEAHQQALDD 1020 LQAEEDKVNS 1030 LNKTKSKLEQ 1040 QVEDLESSLE 1050 QEKKLRVDLE 1060 RNKRKLEGDL 1070 KLAQESILDL 1080 ENDKQQLDER 1090 LKKKDFEYCQ 1100 LQSKVEDEQT 1110 LGLQFQKKIK 1120 ELQARIEELE 1130 EEIEAERATR 1140 AKTEKQRSDY 1150 ARELEELSER 1160 LEEAGGVTST 1170 QIELNKKREA 1180 EFLKLRRDLE 1190 EATLQHEAMV 1200 AALRKKHADS 1210 VAELGEQIDN 1220 LQRVKQKLEK 1230 EKSEFKLEID 1240 DLSSSMESVS 1250 KSKANLEKIC 1260 RTLEDQLSEA 1270 RGKNEEIQRS 1280 LSELTTQKSR 1290 LQTEAGELSR 1300 QLEEKESIVS 1310 QLSRSKQAFT 1320 QQTEELKRQL 1330 EEENKAKNAL 1340 AHALQSSRHD 1350 CDLLREQYEE 1360 EQEGKAELQR 1370 ALSKANSEVA 1380 QWRTKYETDA 1390 IQRTEELEEA 1400 KKKLAQRLQD 1410 SEEQVEAVNA 1420 KCASLEKTKQ 1430 RLQGEVEDLM 1440 VDVERANSLA 1450 AALDKKQRNF 1460 DKVLAEWKTK 1470 CEESQAELEA 1480 SLKESRSLST 1490 ELFKLKNAYE 1500 EALDQLETVK 1510 RENKNLEQEI 1520 ADLTEQIAEN 1530 GKTIHELEKS 1540 RKQIELEKAD 1550 IQLALEEAEA 1560 ALEHEEAKIL 1570 RIQLELTQVK 1580 SEIDRKIAEK 1590 DEEIEQLKRN 1600 YQRTVETMQS 1610 ALDAEVRSRN 1620 EAIRLKKKME 1630 GDLNEIEIQL 1640 SHANRQAAET 1650 LKHLRSVQGQ 1660 LKDTQLHLDD 1670 ALRGQEDLKE 1680 QLAIVERRAN 1690 LLQAEVEELR 1700 ATLEQTERAR 1710 KLAEQELLDS 1720 NERVQLLHTQ 1730 NTSLIHTKKK 1740 LETDLMQLQS 1750 EVEDASRDAR 1760 NAEEKAKKAI 1770 TDAAMMAEEL 1780 KKEQDTSAHL 1790 ERMKKNLEQT 1800 VKDLQHRLDE 1810 AEQLALKGGK 1820 KQIQKLETRI 1830 RELEFELEGE 1840 QKKNTESVKG 1850 LRKYERRVKE 1860 LTYQSEEDRK 1870 NVLRLQDLVD 1880 KLQVKVKSYK 1890 RQAEEADEQA 1900 NAHLTKFRKA 1910 QHELEEAEER 1920 ADIAESQVNK 1930 LRAKTRDFTS 1940 SRMVVHESEE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005859 muscle myosin complex
Cellular Component GO:0032982 myosin filament
Cellular Component GO:0016460 myosin II complex
Cellular Component GO:0030017 sarcomere
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0000146 microfilament motor activity
Molecular Function GO:0017018 myosin phosphatase activity
Biological Process GO:0030048 actin filament-based movement
Biological Process GO:0046034 ATP metabolic process
Biological Process GO:0030326 embryonic limb morphogenesis
Biological Process GO:0060325 face morphogenesis
Biological Process GO:0006936 muscle contraction
Biological Process GO:0030049 muscle filament sliding
Biological Process GO:0007517 muscle organ development
Biological Process GO:0045214 sarcomere organization
Biological Process GO:0003009 skeletal muscle contraction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.