Search Results

Overview

Uniprot IDP11137
Protein NameMicrotubule-associated protein 2
Gene NameMAP2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1017 ASSEKAEKGLSSVPE
107 AEAVAVLKGEQEKEA
1409 EQLETIPKEEKAEKE
1505 HLSCVKRKTTAAGGE
1633 PHTPGTPKSAILVPS
1642 AILVPSEKKVAIIRT
1658 PKSPATPKQLRLINQ
1676 DLKNVKSKIGSTDNI
1697 GQVQIVTKKIDLSHV
1707 DLSHVTSKCGSLKNI
1729 RVKIESVKLDFKEKA
1739 FKEKAQAKVGSLDNA
1761 NVKIDSQKLNFREHA
295 PLTPMREKDVFDDIP
303 DVFDDIPKWEGKQFD
363 TSGPATAKDSFKIEE
579 YFETSALKEEATKSI
665 RMFTIDPKVYGEKRD
832 DAEVARRKSVPSETV
926 LAAAGRVKDEFSVDK
948 GDKSGLSKEFDQEKK

Function

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules

Protein Sequence

10 MADERKDEAK 20 APHWTSAPLT 30 EASAHSHPPE 40 IKDQGGAGEG 50 LVRSANGFPY 60 REDEEGAFGE 70 HGSQGTYSNT 80 KENGINGELT 90 SADRETAEEV 100 SARIVQVVTA 110 EAVAVLKGEQ 120 EKEAQHKDQT 130 AALPLAAEET 140 ANLPPSPPPS 150 PASEQTVTVE 160 EDLLTASKME 170 FHDQQELTPS 180 TAEPSDQKEK 190 ESEKQSKPGE 200 DLKHAALVSQ 210 PETTKTYPDK 220 KDMQGTEEEK 230 APLALFGHTL 240 VASLEDMKQK 250 TEPSLVVPGI 260 DLPKEPPTPK 270 EQKDWFIEMP 280 TEAKKDEWGL 290 VAPISPGPLT 300 PMREKDVFDD 310 IPKWEGKQFD 320 SPMPSPFQGG 330 SFTLPLDVMK 340 NEIVTETSPF 350 APAFLQPDDK 360 KSLQQTSGPA 370 TAKDSFKIEE 380 PHEAKPDKMA 390 EAPPSEAMTL 400 PKDAHIPVVE 410 EHVMGKVLEE 420 EKEAINQETV 430 QQRDTFTPSG 440 QEPILTEKET 450 ELKLEEKTTI 460 SDKEAVPKES 470 KPPKPADEEI 480 GIIQTSTEHT 490 FSEQKDQEPT 500 TDMLKQDSFP 510 VSLEQAVTDS 520 AMTSKTLEKA 530 MTEPSALIEK 540 SSIQELFEMR 550 VDDKDKIEGV 560 GAATSAELDM 570 PFYEDKSGMS 580 KYFETSALKE 590 EATKSIEPGS 600 DYYELSDTRE 610 SVHESIDTMS 620 PMHKNGDKEF 630 QTGKESQPSP 640 PAQEAGYSTL 650 AQSYPSDLPE 660 EPSSPQERMF 670 TIDPKVYGEK 680 RDLHSKNKDD 690 LTLSRSLGLG 700 GRSAIEQRSM 710 SINLPMSCLD 720 SIALGFNFGR 730 GHDLSPLASD 740 ILTNTSGSMD 750 EGDDYLPATT 760 PALEKAPCFP 770 VESKEEEQIE 780 KVKATGEEST 790 QAEISCESPF 800 LAKDFYKNGT 810 VMAPDLPEML 820 DLAGTRSRLA 830 SVSADAEVAR 840 RKSVPSETVV 850 EDSRTGLPPV 860 TDENHVIVKT 870 DSQLEDLGYC 880 VFNKYTVPLP 890 SPVQDSENLS 900 GESGTFYEGT 910 DDKVRRDLAT 920 DLSLIEVKLA 930 AAGRVKDEFS 940 VDKEASAHIS 950 GDKSGLSKEF 960 DQEKKANDRL 970 DTVLEKSEEH 980 ADSKEHAKKT 990 EEAGDEIETF 1000 GLGVTYEQAL 1010 AKDLSIPTDA 1020 SSEKAEKGLS 1030 SVPEIAEVEP 1040 SKKVEQGLDF 1050 AVQGQLDVKI 1060 SDFGQMASGL 1070 NIDDRRATEL 1080 KLEATQDMTP 1090 SSKAPQEADA 1100 FMGVESGHMK 1110 EGTKVSETEV 1120 KEKVAKPDLV 1130 HQEAVDKEES 1140 YESSGEHESL 1150 TMESLKADEG 1160 KKETSPESSL 1170 IQDEIAVKLS 1180 VEIPCPPAVS 1190 EADLATDERA 1200 DVQMEFIQGP 1210 KEESKETPDI 1220 SITPSDVAEP 1230 LHETIVSEPA 1240 EIQSEEEEIE 1250 AQGEYDKLLF 1260 RSDTLQITDL 1270 GVSGAREEFV 1280 ETCPSEHKGV 1290 IESVVTIEDD 1300 FITVVQTTTD 1310 EGESGSHSVR 1320 FAALEQPEVE 1330 RRPSPHDEEE 1340 FEVEEAAEAQ 1350 AEPKDGSPEA 1360 PASPEREEVA 1370 LSEYKTETYD 1380 DYKDETTIDD 1390 SIMDADSLWV 1400 DTQDDDRSIM 1410 TEQLETIPKE 1420 EKAEKEARRS 1430 SLEKHRKEKP 1440 FKTGRGRIST 1450 PERKVAKKEP 1460 STVSRDEVRR 1470 KKAVYKKAEL 1480 AKKTEVQAHS 1490 PSRKFILKPA 1500 IKYTRPTHLS 1510 CVKRKTTAAG 1520 GESALAPSVF 1530 KQAKDKVSDG 1540 VTKSPEKRSS 1550 LPRPSSILPP 1560 RRGVSGDRDE 1570 NSFSLNSSIS 1580 SSARRTTRSE 1590 PIRRAGKSGT 1600 STPTTPGSTA 1610 ITPGTPPSYS 1620 SRTPGTPGTP 1630 SYPRTPHTPG 1640 TPKSAILVPS 1650 EKKVAIIRTP 1660 PKSPATPKQL 1670 RLINQPLPDL 1680 KNVKSKIGST 1690 DNIKYQPKGG 1700 QVQIVTKKID 1710 LSHVTSKCGS 1720 LKNIRHRPGG 1730 GRVKIESVKL 1740 DFKEKAQAKV 1750 GSLDNAHHVP 1760 GGGNVKIDSQ 1770 KLNFREHAKA 1780 RVDHGAEIIT 1790 QSPGRSSVAS 1800 PRRLSNVSSS 1810 GSINLLESPQ 1820 LATLAEDVTA ALAKQGL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0150014 apical distal dendrite
Cellular Component GO:0043203 axon hillock
Cellular Component GO:0043194 axon initial segment
Cellular Component GO:0097441 basal dendrite
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0030425 dendrite
Cellular Component GO:0032839 dendrite cytoplasm
Cellular Component GO:0044307 dendritic branch
Cellular Component GO:1902737 dendritic filopodium
Cellular Component GO:0044294 dendritic growth cone
Cellular Component GO:0043198 dendritic shaft
Cellular Component GO:0150002 distal dendrite
Cellular Component GO:0005874 microtubule
Cellular Component GO:0005875 microtubule associated complex
Cellular Component GO:0043005 neuron projection
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0150001 primary dendrite
Cellular Component GO:1990635 proximal dendrite
Cellular Component GO:1990769 proximal neuron projection
Molecular Function GO:0005516 calmodulin binding
Molecular Function GO:0002162 dystroglycan binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0005198 structural molecule activity
Molecular Function GO:0048156 tau protein binding
Biological Process GO:0021954 central nervous system neuron development
Biological Process GO:0016358 dendrite development
Biological Process GO:0048813 dendrite morphogenesis
Biological Process GO:0000226 microtubule cytoskeleton organization
Biological Process GO:0030517 negative regulation of axon extension
Biological Process GO:0031115 negative regulation of microtubule polymerization
Biological Process GO:0031175 neuron projection development
Biological Process GO:1901953 positive regulation of anterograde dense core granule transport
Biological Process GO:1903744 positive regulation of anterograde synaptic vesicle transport
Biological Process GO:0031113 regulation of microtubule polymerization
Biological Process GO:1902513 regulation of organelle transport along microtubule
Biological Process GO:0032880 regulation of protein localization

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.