Search Results
Overview
| Uniprot ID | P11137 |
|---|---|
| Protein Name | Microtubule-associated protein 2 |
| Gene Name | MAP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1017 | ASSEKAEKGLSSVPE |
| 107 | AEAVAVLKGEQEKEA |
| 1409 | EQLETIPKEEKAEKE |
| 1505 | HLSCVKRKTTAAGGE |
| 1633 | PHTPGTPKSAILVPS |
| 1642 | AILVPSEKKVAIIRT |
| 1658 | PKSPATPKQLRLINQ |
| 1676 | DLKNVKSKIGSTDNI |
| 1697 | GQVQIVTKKIDLSHV |
| 1707 | DLSHVTSKCGSLKNI |
| 1729 | RVKIESVKLDFKEKA |
| 1739 | FKEKAQAKVGSLDNA |
| 1761 | NVKIDSQKLNFREHA |
| 295 | PLTPMREKDVFDDIP |
| 303 | DVFDDIPKWEGKQFD |
| 363 | TSGPATAKDSFKIEE |
| 579 | YFETSALKEEATKSI |
| 665 | RMFTIDPKVYGEKRD |
| 832 | DAEVARRKSVPSETV |
| 926 | LAAAGRVKDEFSVDK |
| 948 | GDKSGLSKEFDQEKK |
Function
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules
Protein Sequence
10
MADERKDEAK
20
APHWTSAPLT
30
EASAHSHPPE
40
IKDQGGAGEG
50
LVRSANGFPY
60
REDEEGAFGE
70
HGSQGTYSNT
80
KENGINGELT
90
SADRETAEEV
100
SARIVQVVTA
110
EAVAVLKGEQ
120
EKEAQHKDQT
130
AALPLAAEET
140
ANLPPSPPPS
150
PASEQTVTVE
160
EDLLTASKME
170
FHDQQELTPS
180
TAEPSDQKEK
190
ESEKQSKPGE
200
DLKHAALVSQ
210
PETTKTYPDK
220
KDMQGTEEEK
230
APLALFGHTL
240
VASLEDMKQK
250
TEPSLVVPGI
260
DLPKEPPTPK
270
EQKDWFIEMP
280
TEAKKDEWGL
290
VAPISPGPLT
300
PMREKDVFDD
310
IPKWEGKQFD
320
SPMPSPFQGG
330
SFTLPLDVMK
340
NEIVTETSPF
350
APAFLQPDDK
360
KSLQQTSGPA
370
TAKDSFKIEE
380
PHEAKPDKMA
390
EAPPSEAMTL
400
PKDAHIPVVE
410
EHVMGKVLEE
420
EKEAINQETV
430
QQRDTFTPSG
440
QEPILTEKET
450
ELKLEEKTTI
460
SDKEAVPKES
470
KPPKPADEEI
480
GIIQTSTEHT
490
FSEQKDQEPT
500
TDMLKQDSFP
510
VSLEQAVTDS
520
AMTSKTLEKA
530
MTEPSALIEK
540
SSIQELFEMR
550
VDDKDKIEGV
560
GAATSAELDM
570
PFYEDKSGMS
580
KYFETSALKE
590
EATKSIEPGS
600
DYYELSDTRE
610
SVHESIDTMS
620
PMHKNGDKEF
630
QTGKESQPSP
640
PAQEAGYSTL
650
AQSYPSDLPE
660
EPSSPQERMF
670
TIDPKVYGEK
680
RDLHSKNKDD
690
LTLSRSLGLG
700
GRSAIEQRSM
710
SINLPMSCLD
720
SIALGFNFGR
730
GHDLSPLASD
740
ILTNTSGSMD
750
EGDDYLPATT
760
PALEKAPCFP
770
VESKEEEQIE
780
KVKATGEEST
790
QAEISCESPF
800
LAKDFYKNGT
810
VMAPDLPEML
820
DLAGTRSRLA
830
SVSADAEVAR
840
RKSVPSETVV
850
EDSRTGLPPV
860
TDENHVIVKT
870
DSQLEDLGYC
880
VFNKYTVPLP
890
SPVQDSENLS
900
GESGTFYEGT
910
DDKVRRDLAT
920
DLSLIEVKLA
930
AAGRVKDEFS
940
VDKEASAHIS
950
GDKSGLSKEF
960
DQEKKANDRL
970
DTVLEKSEEH
980
ADSKEHAKKT
990
EEAGDEIETF
1000
GLGVTYEQAL
1010
AKDLSIPTDA
1020
SSEKAEKGLS
1030
SVPEIAEVEP
1040
SKKVEQGLDF
1050
AVQGQLDVKI
1060
SDFGQMASGL
1070
NIDDRRATEL
1080
KLEATQDMTP
1090
SSKAPQEADA
1100
FMGVESGHMK
1110
EGTKVSETEV
1120
KEKVAKPDLV
1130
HQEAVDKEES
1140
YESSGEHESL
1150
TMESLKADEG
1160
KKETSPESSL
1170
IQDEIAVKLS
1180
VEIPCPPAVS
1190
EADLATDERA
1200
DVQMEFIQGP
1210
KEESKETPDI
1220
SITPSDVAEP
1230
LHETIVSEPA
1240
EIQSEEEEIE
1250
AQGEYDKLLF
1260
RSDTLQITDL
1270
GVSGAREEFV
1280
ETCPSEHKGV
1290
IESVVTIEDD
1300
FITVVQTTTD
1310
EGESGSHSVR
1320
FAALEQPEVE
1330
RRPSPHDEEE
1340
FEVEEAAEAQ
1350
AEPKDGSPEA
1360
PASPEREEVA
1370
LSEYKTETYD
1380
DYKDETTIDD
1390
SIMDADSLWV
1400
DTQDDDRSIM
1410
TEQLETIPKE
1420
EKAEKEARRS
1430
SLEKHRKEKP
1440
FKTGRGRIST
1450
PERKVAKKEP
1460
STVSRDEVRR
1470
KKAVYKKAEL
1480
AKKTEVQAHS
1490
PSRKFILKPA
1500
IKYTRPTHLS
1510
CVKRKTTAAG
1520
GESALAPSVF
1530
KQAKDKVSDG
1540
VTKSPEKRSS
1550
LPRPSSILPP
1560
RRGVSGDRDE
1570
NSFSLNSSIS
1580
SSARRTTRSE
1590
PIRRAGKSGT
1600
STPTTPGSTA
1610
ITPGTPPSYS
1620
SRTPGTPGTP
1630
SYPRTPHTPG
1640
TPKSAILVPS
1650
EKKVAIIRTP
1660
PKSPATPKQL
1670
RLINQPLPDL
1680
KNVKSKIGST
1690
DNIKYQPKGG
1700
QVQIVTKKID
1710
LSHVTSKCGS
1720
LKNIRHRPGG
1730
GRVKIESVKL
1740
DFKEKAQAKV
1750
GSLDNAHHVP
1760
GGGNVKIDSQ
1770
KLNFREHAKA
1780
RVDHGAEIIT
1790
QSPGRSSVAS
1800
PRRLSNVSSS
1810
GSINLLESPQ
1820
LATLAEDVTA
ALAKQGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0150014 | apical distal dendrite |
| Cellular Component | GO:0043203 | axon hillock |
| Cellular Component | GO:0043194 | axon initial segment |
| Cellular Component | GO:0097441 | basal dendrite |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0032839 | dendrite cytoplasm |
| Cellular Component | GO:0044307 | dendritic branch |
| Cellular Component | GO:1902737 | dendritic filopodium |
| Cellular Component | GO:0044294 | dendritic growth cone |
| Cellular Component | GO:0043198 | dendritic shaft |
| Cellular Component | GO:0150002 | distal dendrite |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0005875 | microtubule associated complex |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0150001 | primary dendrite |
| Cellular Component | GO:1990635 | proximal dendrite |
| Cellular Component | GO:1990769 | proximal neuron projection |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0002162 | dystroglycan binding |
| Molecular Function | GO:0008017 | microtubule binding |
| Molecular Function | GO:0005198 | structural molecule activity |
| Molecular Function | GO:0048156 | tau protein binding |
| Biological Process | GO:0021954 | central nervous system neuron development |
| Biological Process | GO:0016358 | dendrite development |
| Biological Process | GO:0048813 | dendrite morphogenesis |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0030517 | negative regulation of axon extension |
| Biological Process | GO:0031115 | negative regulation of microtubule polymerization |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:1901953 | positive regulation of anterograde dense core granule transport |
| Biological Process | GO:1903744 | positive regulation of anterograde synaptic vesicle transport |
| Biological Process | GO:0031113 | regulation of microtubule polymerization |
| Biological Process | GO:1902513 | regulation of organelle transport along microtubule |
| Biological Process | GO:0032880 | regulation of protein localization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.
[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.