Search Results
Overview
| Uniprot ID | P11167 |
|---|---|
| Protein Name | Solute carrier family 2, facilitated glucose transporter member 1 |
| Gene Name | Slc2a1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 245 | TRDLQEMKEEGRQMM |
Function
Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake (PubMed:2211693). Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses (By similarity). Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain (By similarity). In association with BSG and NXNL1, promotes retinal cone survival by increasing glucose uptake into photoreceptors (By similarity). Required for mesendoderm differentiation (By similarity)
Protein Sequence
10
MEPSSKKVTG
20
RLMLAVGGAV
30
LGSLQFGYNT
40
GVINAPQKVI
50
EEFYNQTWNH
60
RYGESIPSTT
70
LTTLWSLSVA
80
IFSVGGMIGS
90
FSVGLFVNRF
100
GRRNSMLMMN
110
LLAFVSAVLM
120
GFSKLGKSFE
130
MLILGRFIIG
140
VYCGLTTGFV
150
PMYVGEVSPT
160
ALRGALGTLH
170
QLGIVVGILI
180
AQVFGLDSIM
190
GNADLWPLLL
200
SVIFIPALLQ
210
CILLPFCPES
220
PRFLLINRNE
230
ENRAKSVLKK
240
LRGTADVTRD
250
LQEMKEEGRQ
260
MMREKKVTIL
270
ELFRSPAYRQ
280
PILIAVVLQL
290
SQQLSGINAV
300
FYYSTSIFEK
310
AGVQQPVYAT
320
IGSGIVNTAF
330
TVVSLFVVER
340
AGRRTLHLIG
350
LAGMAGCAVL
360
MTIALALLEQ
370
LPWMSYLSIV
380
AIFGFVAFFE
390
VGPGPIPWFI
400
VAELFSQGPR
410
PAAVAVAGFS
420
NWTSNFIVGM
430
CFQYVEQLCG
440
PYVFIIFTVL
450
LVLFFIFTYF
460
KVPETKGRTF
470
DEIASGFRQG
480
GASQSDKTPE
490
ELFHPLGADS
QV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0016323 | basolateral plasma membrane |
| Cellular Component | GO:0005901 | caveola |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0030864 | cortical actin cytoskeleton |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0001939 | female pronucleus |
| Cellular Component | GO:1990350 | glucose transporter complex |
| Cellular Component | GO:0014704 | intercalated disc |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0030496 | midbody |
| Cellular Component | GO:0001917 | photoreceptor inner segment |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0031982 | vesicle |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0055056 | D-glucose transmembrane transporter activity |
| Molecular Function | GO:0033300 | dehydroascorbic acid transmembrane transporter activity |
| Molecular Function | GO:0015150 | fucose transmembrane transporter activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0005324 | long-chain fatty acid transmembrane transporter activity |
| Molecular Function | GO:0042910 | xenobiotic transmembrane transporter activity |
| Biological Process | GO:0071474 | cellular hyperosmotic response |
| Biological Process | GO:0042149 | cellular response to glucose starvation |
| Biological Process | GO:0071260 | cellular response to mechanical stimulus |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0098708 | D-glucose import across plasma membrane |
| Biological Process | GO:1904659 | D-glucose transmembrane transport |
| Biological Process | GO:0070837 | dehydroascorbic acid transport |
| Biological Process | GO:0007565 | female pregnancy |
| Biological Process | GO:0015911 | long-chain fatty acid import across plasma membrane |
| Biological Process | GO:0045494 | photoreceptor cell maintenance |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0032868 | response to insulin |
| Biological Process | GO:1904016 | response to Thyroglobulin triiodothyronine |
| Biological Process | GO:0150104 | transport across blood-brain barrier |
| Biological Process | GO:0042908 | xenobiotic transport |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.