Overview
| Uniprot ID | P11168 |
|---|
| Protein Name | Solute carrier family 2, facilitated glucose transporter member 2 |
|---|
| Gene Name | SLC2A2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 501 |
EIAAEFQKKSGSAHR |
Function
Facilitative hexose transporter that mediates the transport of glucose, fructose and galactose (PubMed:16186102, PubMed:23396969, PubMed:28083649, PubMed:8027028, PubMed:8457197). Likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of beta cells (PubMed:8027028). May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney (PubMed:3399500). Also able to mediate the transport of dehydroascorbate and urate (PubMed:23396969, PubMed:40209957)
Protein Sequence
10
MTEDKVTGTL
20
VFTVITAVLG
30
SFQFGYDIGV
40
INAPQQVIIS
50
HYRHVLGVPL
60
DDRKAINNYV
70
INSTDELPTI
80
SYSMNPKPTP
90
WAEEETVAAA
100
QLITMLWSLS
110
VSSFAVGGMT
120
ASFFGGWLGD
130
TLGRIKAMLV
140
ANILSLVGAL
150
LMGFSKLGPS
160
HILIIAGRSI
170
SGLYCGLISG
180
LVPMYIGEIA
190
PTALRGALGT
200
FHQLAIVTGI
210
LISQIIGLEF
220
ILGNYDLWHI
230
LLGLSGVRAI
240
LQSLLLFFCP
250
ESPRYLYIKL
260
DEEVKAKQSL
270
KRLRGYDDVT
280
KDINEMRKER
290
EEASSEQKVS
300
IIQLFTNSSY
310
RQPILVALML
320
HVAQQFSGIN
330
GIFYYSTSIF
340
QTAGISKPVY
350
ATIGVGAVNM
360
VFTAVSVFLV
370
EKAGRRSLFL
380
IGMSGMFVCA
390
IFMSVGLVLL
400
NKFSWMSYVS
410
MIAIFLFVSF
420
FEIGPGPIPW
430
FMVAEFFSQG
440
PRPAALAIAA
450
FSNWTCNFIV
460
ALCFQYIADF
470
CGPYVFFLFA
480
GVLLAFTLFT
490
FFKVPETKGK
500
SFEEIAAEFQ
510
KKSGSAHRPK
520
AAVEMKFLGA
TETV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0016324 |
apical plasma membrane |
| Cellular Component |
GO:0005903 |
brush border |
| Cellular Component |
GO:0005911 |
cell-cell junction |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0055056 |
D-glucose transmembrane transporter activity |
| Molecular Function |
GO:0033300 |
dehydroascorbic acid transmembrane transporter activity |
| Molecular Function |
GO:0005353 |
fructose transmembrane transporter activity |
| Molecular Function |
GO:0005354 |
galactose transmembrane transporter activity |
| Molecular Function |
GO:0015149 |
hexose transmembrane transporter activity |
| Biological Process |
GO:0005975 |
carbohydrate metabolic process |
| Biological Process |
GO:1904659 |
D-glucose transmembrane transport |
| Biological Process |
GO:0070837 |
dehydroascorbic acid transport |
| Biological Process |
GO:0015755 |
fructose transmembrane transport |
| Biological Process |
GO:0015757 |
galactose transmembrane transport |
| Biological Process |
GO:0035774 |
positive regulation of insulin secretion involved in cellular response to glucose stimulus |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.