Search Results
Overview
| Uniprot ID | P11172 |
|---|---|
| Protein Name | Uridine 5'-monophosphate synthase |
| Gene Name | UMPS |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 101 | LIRRKETKDYGTKRL |
Function
Bifunctional enzyme catalyzing the last two steps of de novo pyrimidine biosynthesis, orotate phosphoribosyltransferase (OPRT), which converts orotate to orotidine-5'-monophosphate (OMP), and orotidine-5'-monophosphate decarboxylase (ODC), the terminal enzymatic reaction that decarboxylates OMP to uridine monophosphate (UMP)
Protein Sequence
10
MAVARAALGP
20
LVTGLYDVQA
30
FKFGDFVLKS
40
GLSSPIYIDL
50
RGIVSRPRLL
60
SQVADILFQT
70
AQNAGISFDT
80
VCGVPYTALP
90
LATVICSTNQ
100
IPMLIRRKET
110
KDYGTKRLVE
120
GTINPGETCL
130
IIEDVVTSGS
140
SVLETVEVLQ
150
KEGLKVTDAI
160
VLLDREQGGK
170
DKLQAHGIRL
180
HSVCTLSKML
190
EILEQQKKVD
200
AETVGRVKRF
210
IQENVFVAAN
220
HNGSPLSIKE
230
APKELSFGAR
240
AELPRIHPVA
250
SKLLRLMQKK
260
ETNLCLSADV
270
SLARELLQLA
280
DALGPSICML
290
KTHVDILNDF
300
TLDVMKELIT
310
LAKCHEFLIF
320
EDRKFADIGN
330
TVKKQYEGGI
340
FKIASWADLV
350
NAHVVPGSGV
360
VKGLQEVGLP
370
LHRGCLLIAE
380
MSSTGSLATG
390
DYTRAAVRMA
400
EEHSEFVVGF
410
ISGSRVSMKP
420
EFLHLTPGVQ
430
LEAGGDNLGQ
440
QYNSPQEVIG
450
KRGSDIIIVG
460
RGIISAADRL
470
EAAEMYRKAA
480
WEAYLSRLGV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0004588 | orotate phosphoribosyltransferase activity |
| Molecular Function | GO:0004590 | orotidine-5'-phosphate decarboxylase activity |
| Biological Process | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process |
| Biological Process | GO:0044205 | 'de novo' UMP biosynthetic process |
| Biological Process | GO:0019856 | pyrimidine nucleobase biosynthetic process |
| Biological Process | GO:0006225 | UDP biosynthetic process |
| Biological Process | GO:0006222 | UMP biosynthetic process |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.