Search Results

Overview

Uniprot IDP11216
Protein NameGlycogen phosphorylase, brain form
Gene NamePYGB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 KPLTDSEKRKQISVR
290 NDNFFEGKELRLKQE
3 *****MAKPLTDSEK
465 RIHSEIVKQSVFKDF
545 VKQENKLKFSAFLEK
597 RIKRDPAKAFVPRTV
618 APGYHMAKLIIKLVT
642 PVVGDRLKVIFLENY
811 RNIACSGKFSSDRTI

Function

Glycogen phosphorylase that regulates glycogen mobilization (PubMed:27402852). Phosphorylase is an important allosteric enzyme in carbohydrate metabolism (PubMed:3346228). Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates (PubMed:3346228). However, all known phosphorylases share catalytic and structural properties (PubMed:3346228)

Protein Sequence

10 MAKPLTDSEK 20 RKQISVRGLA 30 GLGDVAEVRK 40 SFNRHLHFTL 50 VKDRNVATPR 60 DYFFALAHTV 70 RDHLVGRWIR 80 TQQHYYERDP 90 KRIYYLSLEF 100 YMGRTLQNTM 110 VNLGLQNACD 120 EAIYQLGLDL 130 EELEEIEEDA 140 GLGNGGLGRL 150 AACFLDSMAT 160 LGLAAYGYGI 170 RYEFGIFNQK 180 IVNGWQVEEA 190 DDWLRYGNPW 200 EKARPEYMLP 210 VHFYGRVEHT 220 PDGVKWLDTQ 230 VVLAMPYDTP 240 VPGYKNNTVN 250 TMRLWSAKAP 260 NDFKLQDFNV 270 GDYIEAVLDR 280 NLAENISRVL 290 YPNDNFFEGK 300 ELRLKQEYFV 310 VAATLQDIIR 320 RFKSSKFGCR 330 DPVRTCFETF 340 PDKVAIQLND 350 THPALSIPEL 360 MRILVDVEKV 370 DWDKAWEITK 380 KTCAYTNHTV 390 LPEALERWPV 400 SMFEKLLPRH 410 LEIIYAINQR 420 HLDHVAALFP 430 GDVDRLRRMS 440 VIEEGDCKRI 450 NMAHLCVIGS 460 HAVNGVARIH 470 SEIVKQSVFK 480 DFYELEPEKF 490 QNKTNGITPR 500 RWLLLCNPGL 510 ADTIVEKIGE 520 EFLTDLSQLK 530 KLLPLVSDEV 540 FIRDVAKVKQ 550 ENKLKFSAFL 560 EKEYKVKINP 570 SSMFDVHVKR 580 IHEYKRQLLN 590 CLHVVTLYNR 600 IKRDPAKAFV 610 PRTVMIGGKA 620 APGYHMAKLI 630 IKLVTSIGDV 640 VNHDPVVGDR 650 LKVIFLENYR 660 VSLAEKVIPA 670 ADLSQQISTA 680 GTEASGTGNM 690 KFMLNGALTI 700 GTMDGANVEM 710 AEEAGAENLF 720 IFGLRVEDVE 730 ALDRKGYNAR 740 EYYDHLPELK 750 QAVDQISSGF 760 FSPKEPDCFK 770 DIVNMLMHHD 780 RFKVFADYEA 790 YMQCQAQVDQ 800 LYRNPKEWTK 810 KVIRNIACSG 820 KFSSDRTITE 830 YAREIWGVEP 840 SDLQIPPPNI PRD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0035578 azurophil granule lumen
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0016020 membrane
Molecular Function GO:0008184 glycogen phosphorylase activity
Molecular Function GO:0030170 pyridoxal phosphate binding
Biological Process GO:0005980 glycogen catabolic process
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.