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Overview

Uniprot ID	P11217
Protein Name	Glycogen phosphorylase, muscle form
Gene Name	PYGM
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
29	VENVTELKKNFNRHL

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Protein Sequence

10 MSRPLSDQEK 20 RKQISVRGLA 30 GVENVTELKK 40 NFNRHLHFTL 50 VKDRNVATPR 60 DYYFALAHTV 70 RDHLVGRWIR 80 TQQHYYEKDP 90 KRIYYLSLEF 100 YMGRTLQNTM 110 VNLALENACD 120 EATYQLGLDM 130 EELEEIEEDA 140 GLGNGGLGRL 150 AACFLDSMAT 160 LGLAAYGYGI 170 RYEFGIFNQK 180 ISGGWQMEEA 190 DDWLRYGNPW 200 EKARPEFTLP 210 VHFYGHVEHT 220 SQGAKWVDTQ 230 VVLAMPYDTP 240 VPGYRNNVVN 250 TMRLWSAKAP 260 NDFNLKDFNV 270 GGYIQAVLDR 280 NLAENISRVL 290 YPNDNFFEGK 300 ELRLKQEYFV 310 VAATLQDIIR 320 RFKSSKFGCR 330 DPVRTNFDAF 340 PDKVAIQLND 350 THPSLAIPEL 360 MRILVDLERM 370 DWDKAWDVTV 380 RTCAYTNHTV 390 LPEALERWPV 400 HLLETLLPRH 410 LQIIYEINQR 420 FLNRVAAAFP 430 GDVDRLRRMS 440 LVEEGAVKRI 450 NMAHLCIAGS 460 HAVNGVARIH 470 SEILKKTIFK 480 DFYELEPHKF 490 QNKTNGITPR 500 RWLVLCNPGL 510 AEVIAERIGE 520 DFISDLDQLR 530 KLLSFVDDEA 540 FIRDVAKVKQ 550 ENKLKFAAYL 560 EREYKVHINP 570 NSLFDIQVKR 580 IHEYKRQLLN 590 CLHVITLYNR 600 IKREPNKFFV 610 PRTVMIGGKA 620 APGYHMAKMI 630 IRLVTAIGDV 640 VNHDPAVGDR 650 LRVIFLENYR 660 VSLAEKVIPA 670 ADLSEQISTA 680 GTEASGTGNM 690 KFMLNGALTI 700 GTMDGANVEM 710 AEEAGEENFF 720 IFGMRVEDVD 730 KLDQRGYNAQ 740 EYYDRIPELR 750 QVIEQLSSGF 760 FSPKQPDLFK 770 DIVNMLMHHD 780 RFKVFADYED 790 YIKCQEKVSA 800 LYKNPREWTR 810 MVIRNIATSG 820 KFSSDRTIAQ 830 YAREIWGVEP 840 SRQRLPAPDE AI

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0070062	extracellular exosome
Molecular Function	GO:0008184	glycogen phosphorylase activity
Molecular Function	GO:0000166	nucleotide binding
Molecular Function	GO:0030170	pyridoxal phosphate binding
Biological Process	GO:0005980	glycogen catabolic process
Biological Process	GO:0005977	glycogen metabolic process

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.