Search Results
Overview
| Uniprot ID | P11232 |
|---|---|
| Protein Name | Thioredoxin |
| Gene Name | Txn |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 3 | *****MVKLIESKEA |
| 8 | MVKLIESKEAFQEAL |
| 85 | QFYKKGQKVGEFSGA |
| 94 | GEFSGANKEKLEATI |
Function
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0047134 | protein-disulfide reductase [NAD(P)H] activity |
| Molecular Function | GO:0015035 | protein-disulfide reductase activity |
| Molecular Function | GO:0004791 | thioredoxin-disulfide reductase (NADPH) activity |
| Biological Process | GO:0045454 | cell redox homeostasis |
| Biological Process | GO:0061692 | cellular detoxification of hydrogen peroxide |
| Biological Process | GO:0071236 | cellular response to antibiotic |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0071455 | cellular response to hyperoxia |
| Biological Process | GO:0071466 | cellular response to xenobiotic stimulus |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0043388 | positive regulation of DNA binding |
| Biological Process | GO:0051897 | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| Biological Process | GO:0014823 | response to activity |
| Biological Process | GO:0048678 | response to axon injury |
| Biological Process | GO:0071548 | response to dexamethasone |
| Biological Process | GO:0071731 | response to nitric oxide |
| Biological Process | GO:0009314 | response to radiation |
| Biological Process | GO:0010269 | response to selenium ion |
| Biological Process | GO:0097068 | response to thyroxine |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.