Overview
| Uniprot ID | P11233 |
|---|
| Protein Name | Ras-related protein Ral-A |
|---|
| Gene Name | RALA |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 7 |
*MAANKPKGQNSLAL |
Function
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors (PubMed:18756269, PubMed:19306925, PubMed:20005108, PubMed:21822277, PubMed:30500825). Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). During mitosis, also controls mitochondrial fission by recruiting to the mitochondrion RALBP1, which mediates the phosphorylation and activation of DNM1L by the mitotic kinase cyclin B-CDK1 (PubMed:21822277)
Protein Sequence
10
MAANKPKGQN
20
SLALHKVIMV
30
GSGGVGKSAL
40
TLQFMYDEFV
50
EDYEPTKADS
60
YRKKVVLDGE
70
EVQIDILDTA
80
GQEDYAAIRD
90
NYFRSGEGFL
100
CVFSITEMES
110
FAATADFREQ
120
ILRVKEDENV
130
PFLLVGNKSD
140
LEDKRQVSVE
150
EAKNRAEQWN
160
VNYVETSAKT
170
RANVDKVFFD
180
LMREIRARKM
190
EDSKEKNGKK
200
KRKSLAKRIR
ERCCIL
Gene Ontology
| Classification |
GO ID |
Description |
| Biological Process |
GO:0072655 |
establishment of protein localization to mitochondrion |
| Biological Process |
GO:0006887 |
exocytosis |
| Biological Process |
GO:0051665 |
membrane raft localization |
| Biological Process |
GO:0001843 |
neural tube closure |
| Biological Process |
GO:0045742 |
positive regulation of epidermal growth factor receptor signaling pathway |
| Biological Process |
GO:0051491 |
positive regulation of filopodium assembly |
| Biological Process |
GO:0090141 |
positive regulation of mitochondrial fission |
| Biological Process |
GO:0007265 |
Ras protein signal transduction |
| Biological Process |
GO:0031623 |
receptor internalization |
| Biological Process |
GO:0032956 |
regulation of actin cytoskeleton organization |
| Biological Process |
GO:0017157 |
regulation of exocytosis |
| Biological Process |
GO:0099149 |
regulation of postsynaptic neurotransmitter receptor internalization |
| Biological Process |
GO:0007165 |
signal transduction |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0032154 |
cleavage furrow |
| Cellular Component |
GO:0030659 |
cytoplasmic vesicle membrane |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0090543 |
Flemming body |
| Cellular Component |
GO:0005925 |
focal adhesion |
| Cellular Component |
GO:0005739 |
mitochondrion |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Cellular Component |
GO:0098685 |
Schaffer collateral - CA1 synapse |
| Cellular Component |
GO:0097060 |
synaptic membrane |
| Molecular Function |
GO:0051117 |
ATPase binding |
| Molecular Function |
GO:0031755 |
Edg-2 lysophosphatidic acid receptor binding |
| Molecular Function |
GO:0003925 |
G protein activity |
| Molecular Function |
GO:0019003 |
GDP binding |
| Molecular Function |
GO:0005525 |
GTP binding |
| Molecular Function |
GO:0003924 |
GTPase activity |
| Molecular Function |
GO:0017022 |
myosin binding |
| Molecular Function |
GO:0031625 |
ubiquitin protein ligase binding |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0006935 |
chemotaxis |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.