Search Results
Overview
| Uniprot ID | P11275 |
|---|---|
| Protein Name | Calcium/calmodulin-dependent protein kinase type II subunit alpha |
| Gene Name | Camk2a |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 146 | ENLLLASKLKGAAVK |
| 250 | EAKDLINKMLTINPS |
| 258 | MLTINPSKRITAAEA |
| 267 | ITAAEALKHPWISHR |
| 291 | QETVDCLKKFNARRK |
| 300 | FNARRKLKGAILTTM |
| 317 | TRNFSGGKSGGNKKN |
| 32 | SVVRRCVKVLAGQEY |
| 42 | AGQEYAAKIINTKKL |
| 461 | VWHRRDGKWQIVHFH |
| 68 | ARICRLLKHPNIVRL |
Function
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in various processes, such as synaptic plasticity, neurotransmitter release and long-term potentiation. Member of the NMDAR signaling complex in excitatory synapses, it regulates NMDAR-dependent potentiation of the AMPAR and therefore excitatory synaptic transmission (PubMed:15312654). Regulates dendritic spine development. Also regulates the migration of developing neurons. Phosphorylates the transcription factor FOXO3 to activate its transcriptional activity (By similarity). Phosphorylates the transcription factor ETS1 in response to calcium signaling, thereby decreasing ETS1 affinity for DNA (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (PubMed:11972023). In response to interferon-beta (IFN-beta) stimulation, stimulates the JAK-STAT signaling pathway (By similarity). In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of PSAT1, inhibiting ferroptosis by promoting GPX4 hydroxylation and stability (By similarity). Acts as a negative regulator of 2-arachidonoylglycerol (2-AG)-mediated synaptic signaling via modulation of DAGLA activity (By similarity)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043005 | neuron projection |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0099524 | postsynaptic cytosol |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:0098685 | Schaffer collateral - CA1 synapse |
| Cellular Component | GO:0045202 | synapse |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0004683 | calcium/calmodulin-dependent protein kinase activity |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0035254 | glutamate receptor binding |
| Molecular Function | GO:0032794 | GTPase activating protein binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0016301 | kinase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Molecular Function | GO:0004674 | protein serine/threonine kinase activity |
| Biological Process | GO:0038166 | angiotensin-activated signaling pathway |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:0035458 | cellular response to interferon-beta |
| Biological Process | GO:0071346 | cellular response to type II interferon |
| Biological Process | GO:0048813 | dendrite morphogenesis |
| Biological Process | GO:0060996 | dendritic spine development |
| Biological Process | GO:0000082 | G1/S transition of mitotic cell cycle |
| Biological Process | GO:0035235 | ionotropic glutamate receptor signaling pathway |
| Biological Process | GO:0110076 | negative regulation of ferroptosis |
| Biological Process | GO:0051346 | negative regulation of hydrolase activity |
| Biological Process | GO:0098877 | neurotransmitter receptor transport to plasma membrane |
| Biological Process | GO:0018105 | peptidyl-serine phosphorylation |
| Biological Process | GO:1990443 | peptidyl-threonine autophosphorylation |
| Biological Process | GO:0051928 | positive regulation of calcium ion transport |
| Biological Process | GO:0010666 | positive regulation of cardiac muscle cell apoptotic process |
| Biological Process | GO:0046427 | positive regulation of receptor signaling pathway via JAK-STAT |
| Biological Process | GO:0046777 | protein autophosphorylation |
| Biological Process | GO:0006468 | protein phosphorylation |
| Biological Process | GO:2000124 | regulation of endocannabinoid signaling pathway |
| Biological Process | GO:1902108 | regulation of mitochondrial membrane permeability involved in apoptotic process |
| Biological Process | GO:2001222 | regulation of neuron migration |
| Biological Process | GO:0048168 | regulation of neuronal synaptic plasticity |
| Biological Process | GO:0098696 | regulation of neurotransmitter receptor localization to postsynaptic specialization membrane |
| Biological Process | GO:0046928 | regulation of neurotransmitter secretion |
| Biological Process | GO:1903076 | regulation of protein localization to plasma membrane |
| Biological Process | GO:0099148 | regulation of synaptic vesicle docking |
| Biological Process | GO:0002931 | response to ischemia |
| Cellular Component | GO:0005954 | calcium- and calmodulin-dependent protein kinase complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0030425 | dendrite |
| Cellular Component | GO:0032839 | dendrite cytoplasm |
| Cellular Component | GO:0043197 | dendritic spine |
Reference
[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.
[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.