Overview
| Uniprot ID | P11493 |
|---|
| Protein Name | Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform |
|---|
| Gene Name | PPP2CB |
|---|
| Organism | Sus scrofa |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 18 |
QVRTLCEKAKEILTK |
Function
Catalytic subunit of protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of a wide variety of enzymes, signal transduction pathways, and cellular events. PP2A can modulate the activity of phosphorylase B kinase, casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation
Protein Sequence
10
LNECKQLNEN
20
QVRTLCEKAK
30
EILTKESNVQ
40
EVRCPVTVCG
50
DVHGQFHDLM
60
ELFRIGGKSP
70
DTNYLFMGDY
80
VDRGYYSVET
90
VTLLVALKVR
100
YPERITILRG
110
NHESRQITQV
120
YGFYDECLRK
130
YGNANVWKYF
140
TDLFDYLPLT
150
ALVDGQIFCL
160
HGGLSPSIDT
170
LDHIRALDRL
180
QEVPHEGPMC
190
DLLWSDPDDR
200
GGWGISPRGA
210
GYTFGQDISE
220
TFNHANGLTL
230
VSRAHQLVME
240
GYNWCHDRNV
250
VTIFSAPNYC
260
YRCGNQAAIM
270
ELDDTLKYSF
280
LQFDPAPRRG
290
EPHVTRRTPD
YFL
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0000775 |
chromosome, centromeric region |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0090443 |
FAR/SIN/STRIPAK complex |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0000922 |
spindle pole |
| Molecular Function |
GO:0046872 |
metal ion binding |
| Molecular Function |
GO:0004722 |
protein serine/threonine phosphatase activity |
| Biological Process |
GO:0000278 |
mitotic cell cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.