Search Results

Overview

Uniprot IDP11498
Protein NamePyruvate carboxylase, mitochondrial
Gene NamePC
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1061 RGKTLHIKALAVSDL
107 PDIIKVAKENNVDAV
1090 QLRSILVKDTQAMKE
1096 VKDTQAMKEMHFHPK
1103 KEMHFHPKALKDVKG
1109 PKALKDVKGQIGAPM
1119 IGAPMPGKVIDIKVV
1124 PGKVIDIKVVAGAKV
1130 IKVVAGAKVAKGQPL
1133 VAGAKVAKGQPLCVL
273 SIQRRHQKVVEIAPA
300 SDSVKLAKQVGYENA
319 FLVDRHGKHYFIEVN
39 LEYKPIKKVMVANRG
434 VKVIAHGKDHPTAAT
442 DHPTAATKMSRALAE
79 TGQMHRQKADEAYLI
892 SKFKEVKKAYVEANQ

Function

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate

Protein Sequence

10 MLKFRTVHGG 20 LRLLGIRRTS 30 TAPAASPNVR 40 RLEYKPIKKV 50 MVANRGEIAI 60 RVFRACTELG 70 IRTVAIYSEQ 80 DTGQMHRQKA 90 DEAYLIGRGL 100 APVQAYLHIP 110 DIIKVAKENN 120 VDAVHPGYGF 130 LSERADFAQA 140 CQDAGVRFIG 150 PSPEVVRKMG 160 DKVEARAIAI 170 AAGVPVVPGT 180 DAPITSLHEA 190 HEFSNTYGFP 200 IIFKAAYGGG 210 GRGMRVVHSY 220 EELEENYTRA 230 YSEALAAFGN 240 GALFVEKFIE 250 KPRHIEVQIL 260 GDQYGNILHL 270 YERDCSIQRR 280 HQKVVEIAPA 290 AHLDPQLRTR 300 LTSDSVKLAK 310 QVGYENAGTV 320 EFLVDRHGKH 330 YFIEVNSRLQ 340 VEHTVTEEIT 350 DVDLVHAQIH 360 VAEGRSLPDL 370 GLRQENIRIN 380 GCAIQCRVTT 390 EDPARSFQPD 400 TGRIEVFRSG 410 EGMGIRLDNA 420 SAFQGAVISP 430 HYDSLLVKVI 440 AHGKDHPTAA 450 TKMSRALAEF 460 RVRGVKTNIA 470 FLQNVLNNQQ 480 FLAGTVDTQF 490 IDENPELFQL 500 RPAQNRAQKL 510 LHYLGHVMVN 520 GPTTPIPVKA 530 SPSPTDPVVP 540 AVPIGPPPAG 550 FRDILLREGP 560 EGFARAVRNH 570 PGLLLMDTTF 580 RDAHQSLLAT 590 RVRTHDLKKI 600 APYVAHNFSK 610 LFSMENWGGA 620 TFDVAMRFLY 630 ECPWRRLQEL 640 RELIPNIPFQ 650 MLLRGANAVG 660 YTNYPDNVVF 670 KFCEVAKENG 680 MDVFRVFDSL 690 NYLPNMLLGM 700 EAAGSAGGVV 710 EAAISYTGDV 720 ADPSRTKYSL 730 QYYMGLAEEL 740 VRAGTHILCI 750 KDMAGLLKPT 760 ACTMLVSSLR 770 DRFPDLPLHI 780 HTHDTSGAGV 790 AAMLACAQAG 800 ADVVDVAADS 810 MSGMTSQPSM 820 GALVACTRGT 830 PLDTEVPMER 840 VFDYSEYWEG 850 ARGLYAAFDC 860 TATMKSGNSD 870 VYENEIPGGQ 880 YTNLHFQAHS 890 MGLGSKFKEV 900 KKAYVEANQM 910 LGDLIKVTPS 920 SKIVGDLAQF 930 MVQNGLSRAE 940 AEAQAEELSF 950 PRSVVEFLQG 960 YIGVPHGGFP 970 EPFRSKVLKD 980 LPRVEGRPGA 990 SLPPLDLQAL 1000 EKELVDRHGE 1010 EVTPEDVLSA 1020 AMYPDVFAHF 1030 KDFTATFGPL 1040 DSLNTRLFLQ 1050 GPKIAEEFEV 1060 ELERGKTLHI 1070 KALAVSDLNR 1080 AGQRQVFFEL 1090 NGQLRSILVK 1100 DTQAMKEMHF 1110 HPKALKDVKG 1120 QIGAPMPGKV 1130 IDIKVVAGAK 1140 VAKGQPLCVL 1150 SAMKMETVVT 1160 SPMEGTVRKV 1170 HVTKDMTLEG DDLILEIE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0009374 biotin binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0004736 pyruvate carboxylase activity
Biological Process GO:0006094 gluconeogenesis
Biological Process GO:0044794 host-mediated activation of viral process
Biological Process GO:0006629 lipid metabolic process
Biological Process GO:0019674 NAD+ metabolic process
Biological Process GO:0006739 NADP+ metabolic process
Biological Process GO:0010629 negative regulation of gene expression
Biological Process GO:0019076 viral release from host cell
Biological Process GO:0019074 viral RNA genome packaging

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.