Search Results
Overview
| Uniprot ID | P11509 |
|---|---|
| Protein Name | Cytochrome P450 2A6 |
| Gene Name | CYP2A6 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 142 | LRDFGVGKRGIEERI |
| 326 | KHPEVEAKVHEEIDR |
| 469 | LKSSQSPKDIDVSPK |
| 476 | KDIDVSPKHVGFATI |
Function
Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide, ifosphamide and tegafur. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo-monooxygenase. Possesses low phenacetin O-deethylation activity
Protein Sequence
10
MLASGMLLVA
20
LLVCLTVMVL
30
MSVWQQRKSK
40
GKLPPGPTPL
50
PFIGNYLQLN
60
TEQMYNSLMK
70
ISERYGPVFT
80
IHLGPRRVVV
90
LCGHDAVREA
100
LVDQAEEFSG
110
RGEQATFDWV
120
FKGYGVVFSN
130
GERAKQLRRF
140
SIATLRDFGV
150
GKRGIEERIQ
160
EEAGFLIDAL
170
RGTGGANIDP
180
TFFLSRTVSN
190
VISSIVFGDR
200
FDYKDKEFLS
210
LLRMMLGIFQ
220
FTSTSTGQLY
230
EMFSSVMKHL
240
PGPQQQAFQL
250
LQGLEDFIAK
260
KVEHNQRTLD
270
PNSPRDFIDS
280
FLIRMQEEEK
290
NPNTEFYLKN
300
LVMTTLNLFI
310
GGTETVSTTL
320
RYGFLLLMKH
330
PEVEAKVHEE
340
IDRVIGKNRQ
350
PKFEDRAKMP
360
YMEAVIHEIQ
370
RFGDVIPMSL
380
ARRVKKDTKF
390
RDFFLPKGTE
400
VYPMLGSVLR
410
DPSFFSNPQD
420
FNPQHFLNEK
430
GQFKKSDAFV
440
PFSIGKRNCF
450
GEGLARMELF
460
LFFTTVMQNF
470
RLKSSQSPKD
480
IDVSPKHVGF
490
ATIPRNYTMS
FLPR
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005881 | cytoplasmic microtubule |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0008392 | arachidonate epoxygenase activity |
| Molecular Function | GO:0008389 | coumarin 7-hydroxylase activity |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0020037 | heme binding |
| Molecular Function | GO:0005506 | iron ion binding |
| Molecular Function | GO:0016712 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen |
| Biological Process | GO:0046226 | coumarin catabolic process |
| Biological Process | GO:0009804 | coumarin metabolic process |
| Biological Process | GO:0019373 | epoxygenase P450 pathway |
| Biological Process | GO:0008202 | steroid metabolic process |
| Biological Process | GO:0042178 | xenobiotic catabolic process |
| Biological Process | GO:0006805 | xenobiotic metabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.