Search Results
Overview
| Uniprot ID | P11531 |
|---|---|
| Protein Name | Dystrophin |
| Gene Name | Dmd |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 1155 | YTRKEALKAGLDKTV |
| 1723 | EDILKRLKAEMNDMR |
| 1924 | IDRELQKKKEELNAV |
Function
Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0045666 | positive regulation of neuron differentiation |
| Cellular Component | GO:0097449 | astrocyte projection |
| Cellular Component | GO:0030424 | axon |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0030055 | cell-substrate junction |
| Cellular Component | GO:0043034 | costamere |
| Cellular Component | GO:0016010 | dystrophin-associated glycoprotein complex |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0031527 | filopodium membrane |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0099617 | matrix side of mitochondrial inner membrane |
| Cellular Component | GO:0045121 | membrane raft |
| Cellular Component | GO:0005741 | mitochondrial outer membrane |
| Cellular Component | GO:0030016 | myofibril |
| Cellular Component | GO:0005883 | neurofilament |
| Cellular Component | GO:0044306 | neuron projection terminus |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Cellular Component | GO:0099572 | postsynaptic specialization |
| Cellular Component | GO:0032991 | protein-containing complex |
| Cellular Component | GO:0005840 | ribosome |
| Cellular Component | GO:0042383 | sarcolemma |
| Cellular Component | GO:0030141 | secretory granule |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0030672 | synaptic vesicle membrane |
| Cellular Component | GO:0030018 | Z disc |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0002162 | dystroglycan binding |
| Molecular Function | GO:0005178 | integrin binding |
| Molecular Function | GO:0005521 | lamin binding |
| Molecular Function | GO:0017022 | myosin binding |
| Molecular Function | GO:0050998 | nitric-oxide synthase binding |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0008307 | structural constituent of muscle |
| Molecular Function | GO:0017166 | vinculin binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0060348 | bone development |
| Biological Process | GO:0086001 | cardiac muscle cell action potential |
| Biological Process | GO:0060048 | cardiac muscle contraction |
| Biological Process | GO:0021987 | cerebral cortex development |
| Biological Process | GO:0061448 | connective tissue development |
| Biological Process | GO:0008340 | determination of adult lifespan |
| Biological Process | GO:0008065 | establishment of blood-nerve barrier |
| Biological Process | GO:0060857 | establishment of glial blood-brain barrier |
| Biological Process | GO:0010467 | gene expression |
| Biological Process | GO:0006954 | inflammatory response |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0060173 | limb development |
| Biological Process | GO:0035264 | multicellular organism growth |
| Biological Process | GO:0046716 | muscle cell cellular homeostasis |
| Biological Process | GO:0055001 | muscle cell development |
| Biological Process | GO:0007517 | muscle organ development |
| Biological Process | GO:0014904 | myotube cell development |
| Biological Process | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| Biological Process | GO:0045665 | negative regulation of neuron differentiation |
| Biological Process | GO:0048666 | neuron development |
| Biological Process | GO:0048812 | neuron projection morphogenesis |
| Biological Process | GO:0051647 | nucleus localization |
| Biological Process | GO:0021629 | olfactory nerve structural organization |
| Biological Process | GO:0043043 | peptide biosynthetic process |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:0001954 | positive regulation of cell-matrix adhesion |
| Biological Process | GO:0010976 | positive regulation of neuron projection development |
| Biological Process | GO:0065003 | protein-containing complex assembly |
| Biological Process | GO:1903409 | reactive oxygen species biosynthetic process |
| Biological Process | GO:1903169 | regulation of calcium ion transmembrane transport |
| Biological Process | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| Biological Process | GO:0090287 | regulation of cellular response to growth factor stimulus |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0002027 | regulation of heart rate |
| Biological Process | GO:0042391 | regulation of membrane potential |
| Biological Process | GO:0090257 | regulation of muscle system process |
| Biological Process | GO:0010880 | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| Biological Process | GO:0014819 | regulation of skeletal muscle contraction |
| Biological Process | GO:0014809 | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| Biological Process | GO:1902305 | regulation of sodium ion transmembrane transport |
| Biological Process | GO:0014894 | response to denervation involved in regulation of muscle adaptation |
| Biological Process | GO:0035994 | response to muscle stretch |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0007519 | skeletal muscle tissue development |
| Biological Process | GO:0043403 | skeletal muscle tissue regeneration |
| Biological Process | GO:0055002 | striated muscle cell development |
| Biological Process | GO:0006941 | striated muscle contraction |
| Biological Process | GO:0099536 | synaptic signaling |
| Biological Process | GO:0090659 | walking behavior |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.