Search Results

Overview

Uniprot IDP11531
Protein NameDystrophin
Gene NameDmd
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
1155 YTRKEALKAGLDKTV
1723 EDILKRLKAEMNDMR
1924 IDRELQKKKEELNAV

Function

Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission

Protein Sequence

10 MLWWEEVEDC 20 YEREDVQKKT 30 FTKWINAQFS 40 KFGKQHIDNL 50 FSDLQDGKRL 60 LDLLEGLTGQ 70 KLPKEKGSTR 80 VHALNNVNKA 90 LRVLQKNNVD 100 LVNIGSTDIV 110 DGNHKLTLGL 120 IWNIILHWQV 130 KNVMKTIMAG 140 LQQTNSEKIL 150 LSWVRQSTRN 160 YPQVNVINFT 170 SSWSDGLALN 180 ALIHSHRPDL 190 FDWNSVVSQH 200 SATQRLEHAF 210 NIAKCQLGIE 220 KLLDPEDVAT 230 TYPDKKSILM 240 YITSLFQVLP 250 QQVSIEAIQE 260 VEMLPRTSSK 270 VTREEHFQLH 280 HQMHYSQQIT 290 VSLAQGYEQT 300 SSSPKPRFKS 310 YAFTQAAYVA 320 TSDSTQSPYP 330 SQHLEAPRDK 340 SLDSSLMETE 350 VNLDSYQTAL 360 EEVLSWLLSA 370 EDTLRAQGEI 380 SNDVEEVKEQ 390 FHAHEGFMMD 400 LTSHQGLVGN 410 VLQLGSQLVG 420 KGKLSEDEEA 430 EVQEQMNLLN 440 SRWECLRVAS 450 MEKQSKLHKV 460 LMDLQNQKLK 470 ELDDWLTKTE 480 ERTKKMEEEP 490 FGPDLEDLKC 500 QVQQHKVLQE 510 DLEQEQVRVN 520 SLTHMVVVVD 530 ESSGDHATAA 540 LEEQLKVLGD 550 RWANICRWTE 560 DRWIVLQDIL 570 LKWQHFTEEQ 580 CLFSTWLSEK 590 EDAMKNIQTS 600 GFKDQNEMMS 610 SLHKISTLKI 620 DLEKKKPTME 630 KLSSLNQDLL 640 SALKNKSVTQ 650 KMEIWMENFA 660 QRWDNLTQKL 670 EKSSAQISQA 680 VTTTQPSLTQ 690 TTVMETVTMV 700 TTREQIMVKH 710 AQEELPPPPP 720 QKKRQITVDS 730 ELRKRLDVDI 740 TELHSWITRS 750 EAVLQSSEFA 760 VYRKEGNISD 770 LQEKVNAIAR 780 EKAEKFRKLQ 790 DASRSAQALV 800 EQMANEGVNA 810 ESIRQASEQL 820 NSRWTEFCQL 830 LSERVNWLEY 840 QTNIITFYNQ 850 LQQLEQMTTT 860 AENLLKTQST 870 TLSEPTAIKS 880 QLKICKDEVN 890 RLSALQPQIE 900 QLKIQSLQLK 910 EKGQGPMFLD 920 ADFVAFTNHF 930 NHIFDGVRAK 940 EKELQTIFDT 950 LPPMRYQETM 960 SSIRTWIQQS 970 ESKLSVPYLS 980 VTEYEIMEER 990 LGKLQALQSS 1000 LKEQQNGFNY 1010 LSDTVKEMAK 1020 KAPSEICQKY 1030 LSEFEEIEGH 1040 WKKLSSQLVE 1050 SCQKLEEHMN 1060 KLRKFQNHIK 1070 TLQKWMAEVD 1080 VFLKEEWPAL 1090 GDAEILKKQL 1100 KQCRLLVGDI 1110 QTIQPSLNSV 1120 NEGGQKIKSE 1130 AELEFASRLE 1140 TELRELNTQW 1150 DHICRQVYTR 1160 KEALKAGLDK 1170 TVSLQKDLSE 1180 MHEWMTQAEE 1190 EYLERDFEYK 1200 TPDELQTAVE 1210 EMKRAKEEAL 1220 QKETKVKLLT 1230 ETVNSVIAHA 1240 PPSAQEALKK 1250 ELETLTTNYQ 1260 WLCTRLNGKC 1270 KTLEEVWACW 1280 HELLSYLEKA 1290 NKWLNEVELK 1300 LKTMENVPAG 1310 PEEITEVLES 1320 LENLMHHSEE 1330 NPNQIRLLAQ 1340 TLTDGGVMDE 1350 LINEELETFN 1360 SRWRELHEEA 1370 VRKQKLLEQS 1380 IQSAQEIEKS 1390 LHLIQESLEF 1400 IDKQLAAYIT 1410 DKVDAAQMPQ 1420 EAQKIQSDLT 1430 SHEISLEEMK 1440 KHNQGKDANQ 1450 RVLSQIDVAQ 1460 KKLQDVSMKF 1470 RLFQKPANFE 1480 QRLEESKMIL 1490 DEVKMHLPAL 1500 ETKSVEQEVI 1510 QSQLSHCVNL 1520 YKSLSEVKSE 1530 VEMVIKTGRQ 1540 IVQKKQTENP 1550 KELDERVTAL 1560 KLHYNELGAK 1570 VTERKQQLEK 1580 CLKLSRKMRK 1590 EMNVLTEWLA 1600 ATDTELTKRS 1610 AVEGMPSNLD 1620 SEVAWGKATQ 1630 KEIEKQKAHL 1640 KSVTELGESL 1650 KMVLGKKETL 1660 VEDKLSLLNS 1670 NWIAVTSRVE 1680 EWLNLLLEYQ 1690 KHMETFDQNI 1700 EQITKWIIHA 1710 DELLDESEKK 1720 KPQQKEDILK 1730 RLKAEMNDMR 1740 PKVDSTRDQA 1750 AKLMANRGDH 1760 CRKVVEPQIS 1770 ELNRRFAAIS 1780 HRIKTGKASI 1790 PLKELEQFNS 1800 DIQKLLEPLE 1810 AEIQQGVNLK 1820 EEDFNKDMSE 1830 DNEGTVNELL 1840 QRGDNLQQRI 1850 TDERKREEIK 1860 IKQQLLQTKH 1870 NALKDLRSQR 1880 RKKALEISHQ 1890 WYQYKRQADD 1900 LLKCLDEIEK 1910 KLASLPEPRD 1920 ERKLKEIDRE 1930 LQKKKEELNA 1940 VRRQAEGLSE 1950 NGAAMAVEPT 1960 QIQLSKRWRQ 1970 IESNFAQFRR 1980 LNFAQIHTLH 1990 EETMVVTTED 2000 MPLDVSYVPS 2010 TYLTEISHIL 2020 QALSEVDHLL 2030 NTPELCAKDF 2040 EDLFKQEESL 2050 KNIKDNLQQI 2060 SGRIDIIHKK 2070 KTAALQSATS 2080 MEKVKVQEAV 2090 AQMDFQGEKL 2100 HRMYKERQGR 2110 FDRSVEKWRH 2120 FHYDMKVFNQ 2130 WLNEVEQFFK 2140 KTQNPENWEH 2150 AKYKWYLKEL 2160 QDGIGQRQAV 2170 VRTLNATGEE 2180 IIQQSSKTDV 2190 NILQEKLGSL 2200 SLRWHDICKE 2210 LAERRKRIEE 2220 QKNVLSEFQR 2230 DLNEFVLWLE 2240 EADNIAITPL 2250 GDEQQLKEQL 2260 EQVKLLAEEL 2270 PLRQGILKQL 2280 NETGGAVLVS 2290 APIRPEEQDK 2300 LEKKLKQTNL 2310 QWIKVSRALP 2320 EKQGELEVHL 2330 KDFRQLEEQL 2340 DHLLLWLSPI 2350 RNQLEIYNQP 2360 SQAGPFDIKE 2370 IEVTVHGKQA 2380 DVERLLSKGQ 2390 HLYKEKPSTQ 2400 PVKRKLEDLR 2410 SEWEAVNHLL 2420 RELRTKQPDR 2430 APGLSTTGAS 2440 ASQTVTLVTQ 2450 SVVTKETVIS 2460 KLEMPSSLLL 2470 EVPALADFNR 2480 AWTELTDWLS 2490 LLDRVIKSQR 2500 VMVGDLEDIN 2510 EMIIKQKATL 2520 QDLEQRRPQL 2530 EELITAAQNL 2540 KNKTSNQEAR 2550 TIITDRIERI 2560 QIQWDEVQEQ 2570 LQNRRQQLNE 2580 MLKDSTQWLE 2590 AKEEAEQVIG 2600 QVRGKLDSWK 2610 EGPHTVDAIQ 2620 KKITETKQLA 2630 KDLRQRQISV 2640 DVANDLALKL 2650 LRDYSADDTR 2660 KVHMITENIN 2670 TSWGNIHKRV 2680 SEQEAALEET 2690 HRLLQQFPLD 2700 LEKFLSWITE 2710 AETTANVLQD 2720 ASRKEKLLED 2730 SRGVRELMKP 2740 WQDLQGEIET 2750 HTDIYHNLDE 2760 NGQKILRSLE 2770 GSDEAPLLQR 2780 RLDNMNFKWS 2790 ELQKKSLNIR 2800 SHLEASSDQW 2810 KRLHLSLQEL 2820 LVWLQLKDDE 2830 LSRQAPIGGD 2840 FPAVQKQNDI 2850 HRAFKRELKT 2860 KEPVIMSTLE 2870 TVRIFLTEQP 2880 LEGLEKLYQE 2890 PRELPPEERA 2900 QNVTRLLRKQ 2910 AEEVNAEWDK 2920 LNLRSADWQR 2930 KIDEALERLQ 2940 ELQEAADELD 2950 LKLRQAEVIK 2960 GSWQPVGDLL 2970 IDSLQDHLEK 2980 VKALRGEIAP 2990 LKENVNRVND 3000 LAHQLTTLGI 3010 QLSPYNLSTL 3020 EDLNTRWRLL 3030 QVAVEDRVRQ 3040 LHEAHRDFGP 3050 ASQHFLSTSV 3060 QGPWERAISP 3070 NKVPYYINHE 3080 TQTTCWDHPK 3090 MTELYQSLAD 3100 LNNVRFSAYR 3110 TAMKLRRLQK 3120 ALCLDLLSLS 3130 AACDALDQHN 3140 LKQNDQPMDI 3150 LQIINCLTTI 3160 YDRLEQEHNN 3170 LVNVPLCVDM 3180 CLNWLLNVYD 3190 TGRTGRIRVL 3200 SFKTGIISLC 3210 KAHLEDKYRY 3220 LFKQVASSTG 3230 FCDQRRLGLL 3240 LHDSIQIPRQ 3250 LGEVASFGGS 3260 NIEPSVRSCF 3270 QFANNKPEIE 3280 AALFLDWMRL 3290 EPQSMVWLPV 3300 LHRVAAAETA 3310 KHQAKCNICK 3320 ECPIIGFRYR 3330 SLKHFNYDIC 3340 QSCFFSGRVA 3350 KGHKMHYPMV 3360 EYCTPTTSGE 3370 DVRDFAKVLK 3380 NKFRTKRYFA 3390 KHPRMGYLPV 3400 QTVLEGDNME 3410 TPVTLINFWP 3420 VDSAPASSPQ 3430 LSHDDTHSRI 3440 EHYASRLAEM 3450 ENSNGSYLND 3460 SISPNESIDD 3470 EHLLIQHYCQ 3480 SLNQDSPLSQ 3490 PRSPAQILIS 3500 LESEERGELE 3510 RILADLEEEN 3520 RNLQAEYDRL 3530 KQQHEHKGLS 3540 PLPSPPEMMP 3550 TSPQSPRDAE 3560 LIAEAKLLRQ 3570 HKGRLEARMQ 3580 ILEDHNKQLE 3590 SQLHRLRQLL 3600 EQPQAEAKVN 3610 GTTVSSPSTS 3620 LQRSDSSQPM 3630 LLRVVGSQTS 3640 ESMGEEDLLS 3650 PPQDTSTGLE 3660 EVMEQLNNSF 3670 PSSRGRNAPG KPMREDTM

Gene Ontology

Classification GO ID Description
Biological Process GO:0045666 positive regulation of neuron differentiation
Cellular Component GO:0097449 astrocyte projection
Cellular Component GO:0030424 axon
Cellular Component GO:0030054 cell junction
Cellular Component GO:0042995 cell projection
Cellular Component GO:0009986 cell surface
Cellular Component GO:0030055 cell-substrate junction
Cellular Component GO:0043034 costamere
Cellular Component GO:0016010 dystrophin-associated glycoprotein complex
Cellular Component GO:0030175 filopodium
Cellular Component GO:0031527 filopodium membrane
Cellular Component GO:0098982 GABA-ergic synapse
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0099617 matrix side of mitochondrial inner membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0030016 myofibril
Cellular Component GO:0005883 neurofilament
Cellular Component GO:0044306 neuron projection terminus
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005634 nucleus
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0045211 postsynaptic membrane
Cellular Component GO:0099572 postsynaptic specialization
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0005840 ribosome
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0030141 secretory granule
Cellular Component GO:0045202 synapse
Cellular Component GO:0030672 synaptic vesicle membrane
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0002162 dystroglycan binding
Molecular Function GO:0005178 integrin binding
Molecular Function GO:0005521 lamin binding
Molecular Function GO:0017022 myosin binding
Molecular Function GO:0050998 nitric-oxide synthase binding
Molecular Function GO:0030165 PDZ domain binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0008307 structural constituent of muscle
Molecular Function GO:0017166 vinculin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006915 apoptotic process
Biological Process GO:0060348 bone development
Biological Process GO:0086001 cardiac muscle cell action potential
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0021987 cerebral cortex development
Biological Process GO:0061448 connective tissue development
Biological Process GO:0008340 determination of adult lifespan
Biological Process GO:0008065 establishment of blood-nerve barrier
Biological Process GO:0060857 establishment of glial blood-brain barrier
Biological Process GO:0010467 gene expression
Biological Process GO:0006954 inflammatory response
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0060173 limb development
Biological Process GO:0035264 multicellular organism growth
Biological Process GO:0046716 muscle cell cellular homeostasis
Biological Process GO:0055001 muscle cell development
Biological Process GO:0007517 muscle organ development
Biological Process GO:0014904 myotube cell development
Biological Process GO:0070373 negative regulation of ERK1 and ERK2 cascade
Biological Process GO:0045665 negative regulation of neuron differentiation
Biological Process GO:0048666 neuron development
Biological Process GO:0048812 neuron projection morphogenesis
Biological Process GO:0051647 nucleus localization
Biological Process GO:0021629 olfactory nerve structural organization
Biological Process GO:0043043 peptide biosynthetic process
Biological Process GO:0008284 positive regulation of cell population proliferation
Biological Process GO:0001954 positive regulation of cell-matrix adhesion
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:1903409 reactive oxygen species biosynthetic process
Biological Process GO:1903169 regulation of calcium ion transmembrane transport
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0090287 regulation of cellular response to growth factor stimulus
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:0010468 regulation of gene expression
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0042391 regulation of membrane potential
Biological Process GO:0090257 regulation of muscle system process
Biological Process GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0014819 regulation of skeletal muscle contraction
Biological Process GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
Biological Process GO:1902305 regulation of sodium ion transmembrane transport
Biological Process GO:0014894 response to denervation involved in regulation of muscle adaptation
Biological Process GO:0035994 response to muscle stretch
Biological Process GO:0009410 response to xenobiotic stimulus
Biological Process GO:0007519 skeletal muscle tissue development
Biological Process GO:0043403 skeletal muscle tissue regeneration
Biological Process GO:0055002 striated muscle cell development
Biological Process GO:0006941 striated muscle contraction
Biological Process GO:0099536 synaptic signaling
Biological Process GO:0090659 walking behavior

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.