Search Results

Overview

Uniprot IDP11532
Protein NameDystrophin
Gene NameDMD
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
3220 DKYRYLFKQVASSTG

Function

Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission

Protein Sequence

10 MLWWEEVEDC 20 YEREDVQKKT 30 FTKWVNAQFS 40 KFGKQHIENL 50 FSDLQDGRRL 60 LDLLEGLTGQ 70 KLPKEKGSTR 80 VHALNNVNKA 90 LRVLQNNNVD 100 LVNIGSTDIV 110 DGNHKLTLGL 120 IWNIILHWQV 130 KNVMKNIMAG 140 LQQTNSEKIL 150 LSWVRQSTRN 160 YPQVNVINFT 170 TSWSDGLALN 180 ALIHSHRPDL 190 FDWNSVVCQQ 200 SATQRLEHAF 210 NIARYQLGIE 220 KLLDPEDVDT 230 TYPDKKSILM 240 YITSLFQVLP 250 QQVSIEAIQE 260 VEMLPRPPKV 270 TKEEHFQLHH 280 QMHYSQQITV 290 SLAQGYERTS 300 SPKPRFKSYA 310 YTQAAYVTTS 320 DPTRSPFPSQ 330 HLEAPEDKSF 340 GSSLMESEVN 350 LDRYQTALEE 360 VLSWLLSAED 370 TLQAQGEISN 380 DVEVVKDQFH 390 THEGYMMDLT 400 AHQGRVGNIL 410 QLGSKLIGTG 420 KLSEDEETEV 430 QEQMNLLNSR 440 WECLRVASME 450 KQSNLHRVLM 460 DLQNQKLKEL 470 NDWLTKTEER 480 TRKMEEEPLG 490 PDLEDLKRQV 500 QQHKVLQEDL 510 EQEQVRVNSL 520 THMVVVVDES 530 SGDHATAALE 540 EQLKVLGDRW 550 ANICRWTEDR 560 WVLLQDILLK 570 WQRLTEEQCL 580 FSAWLSEKED 590 AVNKIHTTGF 600 KDQNEMLSSL 610 QKLAVLKADL 620 EKKKQSMGKL 630 YSLKQDLLST 640 LKNKSVTQKT 650 EAWLDNFARC 660 WDNLVQKLEK 670 STAQISQAVT 680 TTQPSLTQTT 690 VMETVTTVTT 700 REQILVKHAQ 710 EELPPPPPQK 720 KRQITVDSEI 730 RKRLDVDITE 740 LHSWITRSEA 750 VLQSPEFAIF 760 RKEGNFSDLK 770 EKVNAIEREK 780 AEKFRKLQDA 790 SRSAQALVEQ 800 MVNEGVNADS 810 IKQASEQLNS 820 RWIEFCQLLS 830 ERLNWLEYQN 840 NIIAFYNQLQ 850 QLEQMTTTAE 860 NWLKIQPTTP 870 SEPTAIKSQL 880 KICKDEVNRL 890 SDLQPQIERL 900 KIQSIALKEK 910 GQGPMFLDAD 920 FVAFTNHFKQ 930 VFSDVQAREK 940 ELQTIFDTLP 950 PMRYQETMSA 960 IRTWVQQSET 970 KLSIPQLSVT 980 DYEIMEQRLG 990 ELQALQSSLQ 1000 EQQSGLYYLS 1010 TTVKEMSKKA 1020 PSEISRKYQS 1030 EFEEIEGRWK 1040 KLSSQLVEHC 1050 QKLEEQMNKL 1060 RKIQNHIQTL 1070 KKWMAEVDVF 1080 LKEEWPALGD 1090 SEILKKQLKQ 1100 CRLLVSDIQT 1110 IQPSLNSVNE 1120 GGQKIKNEAE 1130 PEFASRLETE 1140 LKELNTQWDH 1150 MCQQVYARKE 1160 ALKGGLEKTV 1170 SLQKDLSEMH 1180 EWMTQAEEEY 1190 LERDFEYKTP 1200 DELQKAVEEM 1210 KRAKEEAQQK 1220 EAKVKLLTES 1230 VNSVIAQAPP 1240 VAQEALKKEL 1250 ETLTTNYQWL 1260 CTRLNGKCKT 1270 LEEVWACWHE 1280 LLSYLEKANK 1290 WLNEVEFKLK 1300 TTENIPGGAE 1310 EISEVLDSLE 1320 NLMRHSEDNP 1330 NQIRILAQTL 1340 TDGGVMDELI 1350 NEELETFNSR 1360 WRELHEEAVR 1370 RQKLLEQSIQ 1380 SAQETEKSLH 1390 LIQESLTFID 1400 KQLAAYIADK 1410 VDAAQMPQEA 1420 QKIQSDLTSH 1430 EISLEEMKKH 1440 NQGKEAAQRV 1450 LSQIDVAQKK 1460 LQDVSMKFRL 1470 FQKPANFEQR 1480 LQESKMILDE 1490 VKMHLPALET 1500 KSVEQEVVQS 1510 QLNHCVNLYK 1520 SLSEVKSEVE 1530 MVIKTGRQIV 1540 QKKQTENPKE 1550 LDERVTALKL 1560 HYNELGAKVT 1570 ERKQQLEKCL 1580 KLSRKMRKEM 1590 NVLTEWLAAT 1600 DMELTKRSAV 1610 EGMPSNLDSE 1620 VAWGKATQKE 1630 IEKQKVHLKS 1640 ITEVGEALKT 1650 VLGKKETLVE 1660 DKLSLLNSNW 1670 IAVTSRAEEW 1680 LNLLLEYQKH 1690 METFDQNVDH 1700 ITKWIIQADT 1710 LLDESEKKKP 1720 QQKEDVLKRL 1730 KAELNDIRPK 1740 VDSTRDQAAN 1750 LMANRGDHCR 1760 KLVEPQISEL 1770 NHRFAAISHR 1780 IKTGKASIPL 1790 KELEQFNSDI 1800 QKLLEPLEAE 1810 IQQGVNLKEE 1820 DFNKDMNEDN 1830 EGTVKELLQR 1840 GDNLQQRITD 1850 ERKREEIKIK 1860 QQLLQTKHNA 1870 LKDLRSQRRK 1880 KALEISHQWY 1890 QYKRQADDLL 1900 KCLDDIEKKL 1910 ASLPEPRDER 1920 KIKEIDRELQ 1930 KKKEELNAVR 1940 RQAEGLSEDG 1950 AAMAVEPTQI 1960 QLSKRWREIE 1970 SKFAQFRRLN 1980 FAQIHTVREE 1990 TMMVMTEDMP 2000 LEISYVPSTY 2010 LTEITHVSQA 2020 LLEVEQLLNA 2030 PDLCAKDFED 2040 LFKQEESLKN 2050 IKDSLQQSSG 2060 RIDIIHSKKT 2070 AALQSATPVE 2080 RVKLQEALSQ 2090 LDFQWEKVNK 2100 MYKDRQGRFD 2110 RSVEKWRRFH 2120 YDIKIFNQWL 2130 TEAEQFLRKT 2140 QIPENWEHAK 2150 YKWYLKELQD 2160 GIGQRQTVVR 2170 TLNATGEEII 2180 QQSSKTDASI 2190 LQEKLGSLNL 2200 RWQEVCKQLS 2210 DRKKRLEEQK 2220 NILSEFQRDL 2230 NEFVLWLEEA 2240 DNIASIPLEP 2250 GKEQQLKEKL 2260 EQVKLLVEEL 2270 PLRQGILKQL 2280 NETGGPVLVS 2290 APISPEEQDK 2300 LENKLKQTNL 2310 QWIKVSRALP 2320 EKQGEIEAQI 2330 KDLGQLEKKL 2340 EDLEEQLNHL 2350 LLWLSPIRNQ 2360 LEIYNQPNQE 2370 GPFDVKETEI 2380 AVQAKQPDVE 2390 EILSKGQHLY 2400 KEKPATQPVK 2410 RKLEDLSSEW 2420 KAVNRLLQEL 2430 RAKQPDLAPG 2440 LTTIGASPTQ 2450 TVTLVTQPVV 2460 TKETAISKLE 2470 MPSSLMLEVP 2480 ALADFNRAWT 2490 ELTDWLSLLD 2500 QVIKSQRVMV 2510 GDLEDINEMI 2520 IKQKATMQDL 2530 EQRRPQLEEL 2540 ITAAQNLKNK 2550 TSNQEARTII 2560 TDRIERIQNQ 2570 WDEVQEHLQN 2580 RRQQLNEMLK 2590 DSTQWLEAKE 2600 EAEQVLGQAR 2610 AKLESWKEGP 2620 YTVDAIQKKI 2630 TETKQLAKDL 2640 RQWQTNVDVA 2650 NDLALKLLRD 2660 YSADDTRKVH 2670 MITENINASW 2680 RSIHKRVSER 2690 EAALEETHRL 2700 LQQFPLDLEK 2710 FLAWLTEAET 2720 TANVLQDATR 2730 KERLLEDSKG 2740 VKELMKQWQD 2750 LQGEIEAHTD 2760 VYHNLDENSQ 2770 KILRSLEGSD 2780 DAVLLQRRLD 2790 NMNFKWSELR 2800 KKSLNIRSHL 2810 EASSDQWKRL 2820 HLSLQELLVW 2830 LQLKDDELSR 2840 QAPIGGDFPA 2850 VQKQNDVHRA 2860 FKRELKTKEP 2870 VIMSTLETVR 2880 IFLTEQPLEG 2890 LEKLYQEPRE 2900 LPPEERAQNV 2910 TRLLRKQAEE 2920 VNTEWEKLNL 2930 HSADWQRKID 2940 ETLERLRELQ 2950 EATDELDLKL 2960 RQAEVIKGSW 2970 QPVGDLLIDS 2980 LQDHLEKVKA 2990 LRGEIAPLKE 3000 NVSHVNDLAR 3010 QLTTLGIQLS 3020 PYNLSTLEDL 3030 NTRWKLLQVA 3040 VEDRVRQLHE 3050 AHRDFGPASQ 3060 HFLSTSVQGP 3070 WERAISPNKV 3080 PYYINHETQT 3090 TCWDHPKMTE 3100 LYQSLADLNN 3110 VRFSAYRTAM 3120 KLRRLQKALC 3130 LDLLSLSAAC 3140 DALDQHNLKQ 3150 NDQPMDILQI 3160 INCLTTIYDR 3170 LEQEHNNLVN 3180 VPLCVDMCLN 3190 WLLNVYDTGR 3200 TGRIRVLSFK 3210 TGIISLCKAH 3220 LEDKYRYLFK 3230 QVASSTGFCD 3240 QRRLGLLLHD 3250 SIQIPRQLGE 3260 VASFGGSNIE 3270 PSVRSCFQFA 3280 NNKPEIEAAL 3290 FLDWMRLEPQ 3300 SMVWLPVLHR 3310 VAAAETAKHQ 3320 AKCNICKECP 3330 IIGFRYRSLK 3340 HFNYDICQSC 3350 FFSGRVAKGH 3360 KMHYPMVEYC 3370 TPTTSGEDVR 3380 DFAKVLKNKF 3390 RTKRYFAKHP 3400 RMGYLPVQTV 3410 LEGDNMETPV 3420 TLINFWPVDS 3430 APASSPQLSH 3440 DDTHSRIEHY 3450 ASRLAEMENS 3460 NGSYLNDSIS 3470 PNESIDDEHL 3480 LIQHYCQSLN 3490 QDSPLSQPRS 3500 PAQILISLES 3510 EERGELERIL 3520 ADLEEENRNL 3530 QAEYDRLKQQ 3540 HEHKGLSPLP 3550 SPPEMMPTSP 3560 QSPRDAELIA 3570 EAKLLRQHKG 3580 RLEARMQILE 3590 DHNKQLESQL 3600 HRLRQLLEQP 3610 QAEAKVNGTT 3620 VSSPSTSLQR 3630 SDSSQPMLLR 3640 VVGSQTSDSM 3650 GEEDLLSPPQ 3660 DTSTGLEEVM 3670 EQLNNSFPSS 3680 RGRNTPGKPM REDTM

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0030055 cell-substrate junction
Cellular Component GO:0043034 costamere
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016010 dystrophin-associated glycoprotein complex
Cellular Component GO:0030175 filopodium
Cellular Component GO:0031527 filopodium membrane
Cellular Component GO:0045121 membrane raft
Cellular Component GO:0044306 neuron projection terminus
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0045211 postsynaptic membrane
Cellular Component GO:0032991 protein-containing complex
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0045202 synapse
Cellular Component GO:0016013 syntrophin complex
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0002162 dystroglycan binding
Molecular Function GO:0017022 myosin binding
Molecular Function GO:0050998 nitric-oxide synthase binding
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0008307 structural constituent of muscle
Molecular Function GO:0017166 vinculin binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0043010 camera-type eye development
Biological Process GO:0086001 cardiac muscle cell action potential
Biological Process GO:0060048 cardiac muscle contraction
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0035633 maintenance of blood-brain barrier
Biological Process GO:0044458 motile cilium assembly
Biological Process GO:0046716 muscle cell cellular homeostasis
Biological Process GO:0055001 muscle cell development
Biological Process GO:0007517 muscle organ development
Biological Process GO:0048666 neuron development
Biological Process GO:0043043 peptide biosynthetic process
Biological Process GO:0045666 positive regulation of neuron differentiation
Biological Process GO:0010976 positive regulation of neuron projection development
Biological Process GO:0065003 protein-containing complex assembly
Biological Process GO:1903169 regulation of calcium ion transmembrane transport
Biological Process GO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
Biological Process GO:0090287 regulation of cellular response to growth factor stimulus
Biological Process GO:0002027 regulation of heart rate
Biological Process GO:0090257 regulation of muscle system process
Biological Process GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
Biological Process GO:0014819 regulation of skeletal muscle contraction
Biological Process GO:0014809 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion
Biological Process GO:1902305 regulation of sodium ion transmembrane transport
Biological Process GO:0035994 response to muscle stretch
Biological Process GO:0007519 skeletal muscle tissue development
Biological Process GO:0099536 synaptic signaling

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.