Search Results
Overview
| Uniprot ID | P11598 |
|---|---|
| Protein Name | Protein disulfide-isomerase A3 |
| Gene Name | Pdia3 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 130 | GIVSHLKKQAGPASV |
| 218 | LANKFEDKIVAYTEK |
| 225 | KIVAYTEKKMTSGKI |
| 335 | IRTAKGEKFVMQEEF |
| 366 | GNLKRYLKSEPIPET |
Function
Protein disulfide isomerase that catalyzes the formation, isomerization, and reduction or oxidation of disulfide bonds in client proteins and functions as a protein folding chaperone. Core component of the major histocompatibility complex class I (MHC I) peptide loading complex where it functions as an essential folding chaperone for TAPBP. Through TAPBP, assists the dynamic assembly of the MHC I complex with high affinity antigens in the endoplasmic reticulum. Therefore, plays a crucial role in the presentation of antigens to cytotoxic T cells in adaptive immunity
Protein Sequence
10
MRFSCLALLP
20
GVALLLASAL
30
LASASDVLEL
40
TDENFESRVS
50
DTGSAGLMLV
60
EFFAPWCGHC
70
KRLAPEYEAA
80
ATRLKGIVPL
90
AKVDCTANTN
100
TCNKYGVSGY
110
PTLKIFRDGE
120
EAGAYDGPRT
130
ADGIVSHLKK
140
QAGPASVPLR
150
TEDEFKKFIS
160
DKDASVVGFF
170
RDLFSDGHSE
180
FLKAASNLRD
190
NYRFAHTNVE
200
SLVKEYDDNG
210
EGITIFRPLH
220
LANKFEDKIV
230
AYTEKKMTSG
240
KIKKFIQESI
250
FGLCPHMTED
260
NKDLIQGKDL
270
LTAYYDVDYE
280
KNTKGSNYWR
290
NRVMMVAKTF
300
LDAGHKLNFA
310
VASRKTFSHE
320
LSDFGLESTT
330
GEIPVVAIRT
340
AKGEKFVMQE
350
EFSRDGKALE
360
RFLQEYFDGN
370
LKRYLKSEPI
380
PETNEGPVKV
390
VVAESFDDIV
400
NAEDKDVLIE
410
FYAPWCGHCK
420
NLEPKYKELG
430
EKLSKDPNIV
440
IAKMDATAND
450
VPSPYEVKGF
460
PTIYFSPANK
470
KLTPKKYEGG
480
RELNDFISYL
490
QREATNPPII
500
QEEKPKKKKK
AQEDL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005788 | endoplasmic reticulum lumen |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0042824 | MHC class I peptide loading complex |
| Cellular Component | GO:0005790 | smooth endoplasmic reticulum |
| Cellular Component | GO:0042825 | TAP complex |
| Cellular Component | GO:0061779 | Tapasin-ERp57 complex |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0106222 | lncRNA binding |
| Molecular Function | GO:0042288 | MHC class I protein binding |
| Molecular Function | GO:0008233 | peptidase activity |
| Molecular Function | GO:0003756 | protein disulfide isomerase activity |
| Molecular Function | GO:0044183 | protein folding chaperone |
| Molecular Function | GO:0019153 | protein-disulfide reductase (glutathione) activity |
| Molecular Function | GO:0015035 | protein-disulfide reductase activity |
| Biological Process | GO:0002250 | adaptive immune response |
| Biological Process | GO:0098761 | cellular response to interleukin-7 |
| Biological Process | GO:1904148 | cellular response to nonylphenol |
| Biological Process | GO:0071560 | cellular response to transforming growth factor beta stimulus |
| Biological Process | GO:0071305 | cellular response to vitamin D |
| Biological Process | GO:0007623 | circadian rhythm |
| Biological Process | GO:0002502 | peptide antigen assembly with MHC class I protein complex |
| Biological Process | GO:0070527 | platelet aggregation |
| Biological Process | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway |
| Biological Process | GO:1903334 | positive regulation of protein folding |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:1901423 | response to benzene |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
| Biological Process | GO:0045471 | response to ethanol |
| Biological Process | GO:0033595 | response to genistein |
| Biological Process | GO:0055093 | response to hyperoxia |
| Biological Process | GO:0001666 | response to hypoxia |
| Biological Process | GO:0002931 | response to ischemia |
| Biological Process | GO:0044321 | response to leptin |
| Biological Process | GO:0031667 | response to nutrient levels |
Reference
[1] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.