Search Results
Overview
| Uniprot ID | P11708 |
|---|---|
| Protein Name | Malate dehydrogenase, cytoplasmic |
| Gene Name | MDH1 |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 103 | MERKDLLKANVKIFK |
| 107 | DLLKANVKIFKCQGA |
| 110 | KANVKIFKCQGAALD |
| 118 | CQGAALDKYAKKSVK |
| 125 | KYAKKSVKVIVVGNP |
| 142 | TNCLTASKSAPSIPK |
| 149 | KSAPSIPKENFSCLT |
| 164 | RLDHNRAKAQIALKL |
| 199 | YPDVNHAKVKLQAKE |
| 205 | AKVKLQAKEVGVYEA |
| 236 | QRGAAVIKARKLSSA |
| 239 | AAVIKARKLSSAMSA |
| 248 | SSAMSAAKAICDHVR |
Function
Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH. Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation. Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS)
Protein Sequence
10
MSEPIRVLVT
20
GAAGQIAYSL
30
LYSIGNGSVF
40
GKDQPIILVL
50
LDITPMMGVL
60
DGVLMELQDC
70
ALPLLKDVIA
80
TDKEEIAFKD
90
LDVAILVGSM
100
PRRDGMERKD
110
LLKANVKIFK
120
CQGAALDKYA
130
KKSVKVIVVG
140
NPANTNCLTA
150
SKSAPSIPKE
160
NFSCLTRLDH
170
NRAKAQIALK
180
LGVTSDDVKN
190
VIIWGNHSST
200
QYPDVNHAKV
210
KLQAKEVGVY
220
EAVKDDSWLK
230
GEFITTVQQR
240
GAAVIKARKL
250
SSAMSAAKAI
260
CDHVRDIWFG
270
TPEGEFVSMG
280
IISDGNSYGV
290
PDDLLYSFPV
300
TIKDKTWKIV
310
EGLPINDFSR
320
EKMDLTAKEL
330
AEEKETAFEF
LSSA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0047995 | (2R)-hydroxyphenylpyruvate reductase [NAD(P)H] activity |
| Molecular Function | GO:0030060 | L-malate dehydrogenase (NAD+) activity |
| Molecular Function | GO:0051287 | NAD binding |
| Biological Process | GO:0006108 | malate metabolic process |
| Biological Process | GO:0019674 | NAD+ metabolic process |
| Biological Process | GO:0006107 | oxaloacetate metabolic process |
| Biological Process | GO:0006099 | tricarboxylic acid cycle |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.