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Overview

Uniprot IDP11717
Protein NameCation-independent mannose-6-phosphate receptor
Gene NameIGF2R
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1030 YKGPLSAKGTADAFI
1104 TGLSTVRKPWTAVDT
1372 DLTECSFKDGAGNSF
170 KDIFKANKEVPCYVF
183 VFDEELRKHDLNPLI

Function

Mediates the transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes (PubMed:18817523, PubMed:2963003). Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:18817523, PubMed:2963003). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer (PubMed:18817523). This receptor also binds IGF2 (PubMed:18046459). Acts as a positive regulator of T-cell coactivation by binding DPP4 (PubMed:10900005)

Protein Sequence

10 MGAAAGRSPH 20 LGPAPARRPQ 30 RSLLLLQLLL 40 LVAAPGSTQA 50 QAAPFPELCS 60 YTWEAVDTKN 70 NVLYKINICG 80 SVDIVQCGPS 90 SAVCMHDLKT 100 RTYHSVGDSV 110 LRSATRSLLE 120 FNTTVSCDQQ 130 GTNHRVQSSI 140 AFLCGKTLGT 150 PEFVTATECV 160 HYFEWRTTAA 170 CKKDIFKANK 180 EVPCYVFDEE 190 LRKHDLNPLI 200 KLSGAYLVDD 210 SDPDTSLFIN 220 VCRDIDTLRD 230 PGSQLRACPP 240 GTAACLVRGH 250 QAFDVGQPRD 260 GLKLVRKDRL 270 VLSYVREEAG 280 KLDFCDGHSP 290 AVTITFVCPS 300 ERREGTIPKL 310 TAKSNCRYEI 320 EWITEYACHR 330 DYLESKTCSL 340 SGEQQDVSID 350 LTPLAQSGGS 360 SYISDGKEYL 370 FYLNVCGETE 380 IQFCNKKQAA 390 VCQVKKSDTS 400 QVKAAGRYHN 410 QTLRYSDGDL 420 TLIYFGGDEC 430 SSGFQRMSVI 440 NFECNKTAGN 450 DGKGTPVFTG 460 EVDCTYFFTW 470 DTEYACVKEK 480 EDLLCGATDG 490 KKRYDLSALV 500 RHAEPEQNWE 510 AVDGSQTETE 520 KKHFFINICH 530 RVLQEGKARG 540 CPEDAAVCAV 550 DKNGSKNLGK 560 FISSPMKEKG 570 NIQLSYSDGD 580 DCGHGKKIKT 590 NITLVCKPGD 600 LESAPVLRTS 610 GEGGCFYEFE 620 WHTAAACVLS 630 KTEGENCTVF 640 DSQAGFSFDL 650 SPLTKKNGAY 660 KVETKKYDFY 670 INVCGPVSVS 680 PCQPDSGACQ 690 VAKSDEKTWN 700 LGLSNAKLSY 710 YDGMIQLNYR 720 GGTPYNNERH 730 TPRATLITFL 740 CDRDAGVGFP 750 EYQEEDNSTY 760 NFRWYTSYAC 770 PEEPLECVVT 780 DPSTLEQYDL 790 SSLAKSEGGL 800 GGNWYAMDNS 810 GEHVTWRKYY 820 INVCRPLNPV 830 PGCNRYASAC 840 QMKYEKDQGS 850 FTEVVSISNL 860 GMAKTGPVVE 870 DSGSLLLEYV 880 NGSACTTSDG 890 RQTTYTTRIH 900 LVCSRGRLNS 910 HPIFSLNWEC 920 VVSFLWNTEA 930 ACPIQTTTDT 940 DQACSIRDPN 950 SGFVFNLNPL 960 NSSQGYNVSG 970 IGKIFMFNVC 980 GTMPVCGTIL 990 GKPASGCEAE 1000 TQTEELKNWK 1010 PARPVGIEKS 1020 LQLSTEGFIT 1030 LTYKGPLSAK 1040 GTADAFIVRF 1050 VCNDDVYSGP 1060 LKFLHQDIDS 1070 GQGIRNTYFE 1080 FETALACVPS 1090 PVDCQVTDLA 1100 GNEYDLTGLS 1110 TVRKPWTAVD 1120 TSVDGRKRTF 1130 YLSVCNPLPY 1140 IPGCQGSAVG 1150 SCLVSEGNSW 1160 NLGVVQMSPQ 1170 AAANGSLSIM 1180 YVNGDKCGNQ 1190 RFSTRITFEC 1200 AQISGSPAFQ 1210 LQDGCEYVFI 1220 WRTVEACPVV 1230 RVEGDNCEVK 1240 DPRHGNLYDL 1250 KPLGLNDTIV 1260 SAGEYTYYFR 1270 VCGKLSSDVC 1280 PTSDKSKVVS 1290 SCQEKREPQG 1300 FHKVAGLLTQ 1310 KLTYENGLLK 1320 MNFTGGDTCH 1330 KVYQRSTAIF 1340 FYCDRGTQRP 1350 VFLKETSDCS 1360 YLFEWRTQYA 1370 CPPFDLTECS 1380 FKDGAGNSFD 1390 LSSLSRYSDN 1400 WEAITGTGDP 1410 EHYLINVCKS 1420 LAPQAGTEPC 1430 PPEAAACLLG 1440 GSKPVNLGRV 1450 RDGPQWRDGI 1460 IVLKYVDGDL 1470 CPDGIRKKST 1480 TIRFTCSESQ 1490 VNSRPMFISA 1500 VEDCEYTFAW 1510 PTATACPMKS 1520 NEHDDCQVTN 1530 PSTGHLFDLS 1540 SLSGRAGFTA 1550 AYSEKGLVYM 1560 SICGENENCP 1570 PGVGACFGQT 1580 RISVGKANKR 1590 LRYVDQVLQL 1600 VYKDGSPCPS 1610 KSGLSYKSVI 1620 SFVCRPEARP 1630 TNRPMLISLD 1640 KQTCTLFFSW 1650 HTPLACEQAT 1660 ECSVRNGSSI 1670 VDLSPLIHRT 1680 GGYEAYDESE 1690 DDASDTNPDF 1700 YINICQPLNP 1710 MHGVPCPAGA 1720 AVCKVPIDGP 1730 PIDIGRVAGP 1740 PILNPIANEI 1750 YLNFESSTPC 1760 LADKHFNYTS 1770 LIAFHCKRGV 1780 SMGTPKLLRT 1790 SECDFVFEWE 1800 TPVVCPDEVR 1810 MDGCTLTDEQ 1820 LLYSFNLSSL 1830 STSTFKVTRD 1840 SRTYSVGVCT 1850 FAVGPEQGGC 1860 KDGGVCLLSG 1870 TKGASFGRLQ 1880 SMKLDYRHQD 1890 EAVVLSYVNG 1900 DRCPPETDDG 1910 VPCVFPFIFN 1920 GKSYEECIIE 1930 SRAKLWCSTT 1940 ADYDRDHEWG 1950 FCRHSNSYRT 1960 SSIIFKCDED 1970 EDIGRPQVFS 1980 EVRGCDVTFE 1990 WKTKVVCPPK 2000 KLECKFVQKH 2010 KTYDLRLLSS 2020 LTGSWSLVHN 2030 GVSYYINLCQ 2040 KIYKGPLGCS 2050 ERASICRRTT 2060 TGDVQVLGLV 2070 HTQKLGVIGD 2080 KVVVTYSKGY 2090 PCGGNKTASS 2100 VIELTCTKTV 2110 GRPAFKRFDI 2120 DSCTYYFSWD 2130 SRAACAVKPQ 2140 EVQMVNGTIT 2150 NPINGKSFSL 2160 GDIYFKLFRA 2170 SGDMRTNGDN 2180 YLYEIQLSSI 2190 TSSRNPACSG 2200 ANICQVKPND 2210 QHFSRKVGTS 2220 DKTKYYLQDG 2230 DLDVVFASSS 2240 KCGKDKTKSV 2250 SSTIFFHCDP 2260 LVEDGIPEFS 2270 HETADCQYLF 2280 SWYTSAVCPL 2290 GVGFDSENPG 2300 DDGQMHKGLS 2310 ERSQAVGAVL 2320 SLLLVALTCC 2330 LLALLLYKKE 2340 RRETVISKLT 2350 TCCRRSSNVS 2360 YKYSKVNKEE 2370 ETDENETEWL 2380 MEEIQLPPPR 2390 QGKEGQENGH 2400 ITTKSVKALS 2410 SLHGDDQDSE 2420 DEVLTIPEVK 2430 VHSGRGAGAE 2440 SSHPVRNAQS 2450 NALQEREDDR 2460 VGLVRGEKAR 2470 KGKSSSAQQK 2480 TVSSTKLVSF 2490 HDDSDEDLLH I

Gene Ontology

Classification GO ID Description
Cellular Component GO:0009986 cell surface
Cellular Component GO:0030118 clathrin coat
Cellular Component GO:0030669 clathrin-coated endocytic vesicle membrane
Cellular Component GO:0005769 early endosome
Cellular Component GO:0030139 endocytic vesicle
Cellular Component GO:0005768 endosome
Cellular Component GO:0010008 endosome membrane
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0000139 Golgi membrane
Cellular Component GO:0005770 late endosome
Cellular Component GO:0016020 membrane
Cellular Component GO:0005641 nuclear envelope lumen
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0030667 secretory granule membrane
Cellular Component GO:0005802 trans-Golgi network
Cellular Component GO:0032588 trans-Golgi network membrane
Cellular Component GO:0030140 trans-Golgi network transport vesicle
Cellular Component GO:0030133 transport vesicle
Molecular Function GO:0005537 D-mannose binding
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0001965 G-protein alpha-subunit binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0005520 insulin-like growth factor binding
Molecular Function GO:0031995 insulin-like growth factor II binding
Molecular Function GO:0005010 insulin-like growth factor receptor activity
Molecular Function GO:0051219 phosphoprotein binding
Molecular Function GO:0001972 retinoic acid binding
Molecular Function GO:1905394 retromer complex binding
Molecular Function GO:0038023 signaling receptor activity
Biological Process GO:0031100 animal organ regeneration
Biological Process GO:0007186 G protein-coupled receptor signaling pathway
Biological Process GO:0044794 host-mediated activation of viral process
Biological Process GO:0001889 liver development
Biological Process GO:0043065 positive regulation of apoptotic process
Biological Process GO:0009791 post-embryonic development
Biological Process GO:0006622 protein targeting to lysosome
Biological Process GO:0006898 receptor-mediated endocytosis
Biological Process GO:0032526 response to retinoic acid
Biological Process GO:1904772 response to tetrachloromethane
Biological Process GO:0007165 signal transduction
Biological Process GO:0007283 spermatogenesis

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.