Search Results

Overview

Uniprot ID	P11730
Protein Name	Calcium/calmodulin-dependent protein kinase type II subunit gamma
Gene Name	Camk2g
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
43	STQEYAAKIINTKKL

Function

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (By similarity). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (By similarity). In the central nervous system, it is involved in the regulation of neurite formation and arborization. It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity)

Protein Sequence

10 MATTATCTRF 20 TDDYQLFEEL 30 GKGAFSVVRR 40 CVKKTSTQEY 50 AAKIINTKKL 60 SARDHQKLER 70 EARICRLLKH 80 PNIVRLHDSI 90 SEEGFHYLVF 100 DLVTGGELFE 110 DIVAREYYSE 120 ADASHCIHQI 130 LESVNHIHQH 140 DIVHRDLKPE 150 NLLLASKCKG 160 AAVKLADFGL 170 AIEVQGEQQA 180 WFGFAGTPGY 190 LSPEVLRKDP 200 YGKPVDIWAC 210 GVILYILLVG 220 YPPFWDEDQH 230 KLYQQIKAGA 240 YDFPSPEWDT 250 VTPEAKNLIN 260 QMLTINPAKR 270 ITADQALKHP 280 WVCQRSTVAS 290 MMHRQETVEC 300 LRKFNARRKL 310 KGAILTTMLV 320 SRNFSVGRQS 330 SAPASPAASA 340 AGLAGQAAKS 350 LLNKKSDGGV 360 KKRKSSSSVH 370 LMEPQTTVVH 380 NATDGIKGST 390 ESCNTTTEDE 400 DLKVRKQEII 410 KITEQLIEAI 420 NNGDFEAYTK 430 ICDPGLTSFE 440 PEALGNLVEG 450 MDFHKFYFEN 460 LLSKNSKPIH 470 TTILNPHVHV 480 IGEDAACIAY 490 IRLTQYIDGQ 500 GRPRTSQSEE 510 TRVWHRRDGK 520 WLNVHYHCSG APAAPLQ

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005954	calcium- and calmodulin-dependent protein kinase complex
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0098978	glutamatergic synapse
Cellular Component	GO:0043005	neuron projection
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0099524	postsynaptic cytosol
Cellular Component	GO:0014069	postsynaptic density
Cellular Component	GO:0033017	sarcoplasmic reticulum membrane
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004683	calcium/calmodulin-dependent protein kinase activity
Molecular Function	GO:0005516	calmodulin binding
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0042803	protein homodimerization activity
Molecular Function	GO:0106310	protein serine kinase activity
Molecular Function	GO:0004674	protein serine/threonine kinase activity
Biological Process	GO:0006816	calcium ion transport
Biological Process	GO:0030154	cell differentiation
Biological Process	GO:0000082	G1/S transition of mitotic cell cycle
Biological Process	GO:0007399	nervous system development
Biological Process	GO:0046777	protein autophosphorylation
Biological Process	GO:0048169	regulation of long-term neuronal synaptic plasticity
Biological Process	GO:0010975	regulation of neuron projection development
Biological Process	GO:0048168	regulation of neuronal synaptic plasticity
Biological Process	GO:0099072	regulation of postsynaptic membrane neurotransmitter receptor levels
Biological Process	GO:1903076	regulation of protein localization to plasma membrane
Biological Process	GO:1901897	regulation of relaxation of cardiac muscle
Biological Process	GO:0001666	response to hypoxia
Biological Process	GO:0006979	response to oxidative stress

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.