Search Results
Overview
| Uniprot ID | P11762 |
|---|---|
| Protein Name | Galectin-1 |
| Gene Name | Lgals1 |
| Organism | Rattus norvegicus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 108 | LPDGHEFKFPNRLNM |
| 19 | LKPGECLKVRGELAP |
| 29 | GELAPDAKSFVLNLG |
Function
Lectin that binds beta-galactoside and a wide array of complex carbohydrates. Plays a role in regulating apoptosis, cell proliferation and cell differentiation. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase. Strong inducer of T-cell apoptosis. Plays a negative role in Th17 cell differentiation via activation of the receptor CD69
Protein Sequence
10
MACGLVASNL
20
NLKPGECLKV
30
RGELAPDAKS
40
FVLNLGKDSN
50
NLCLHFNPRF
60
NAHGDANTIV
70
CNSKDDGTWG
80
TEQRETAFPF
90
QPGSITEVCI
100
TFDQADLTIK
110
LPDGHEFKFP
120
NRLNMEAINY
130
MAADGDFKIK
CVAFE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0009986 | cell surface |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005615 | extracellular space |
| Cellular Component | GO:1990724 | galectin complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0030246 | carbohydrate binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0030395 | lactose binding |
| Molecular Function | GO:0043236 | laminin binding |
| Molecular Function | GO:0048018 | receptor ligand activity |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0098609 | cell-cell adhesion |
| Biological Process | GO:0071333 | cellular response to glucose stimulus |
| Biological Process | GO:0045445 | myoblast differentiation |
| Biological Process | GO:0010812 | negative regulation of cell-substrate adhesion |
| Biological Process | GO:0010977 | negative regulation of neuron projection development |
| Biological Process | GO:2000329 | negative regulation of T-helper 17 cell lineage commitment |
| Biological Process | GO:0002317 | plasma cell differentiation |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0034120 | positive regulation of erythrocyte aggregation |
| Biological Process | GO:0050729 | positive regulation of inflammatory response |
| Biological Process | GO:0046598 | positive regulation of viral entry into host cell |
| Biological Process | GO:0048678 | response to axon injury |
| Biological Process | GO:0035900 | response to isolation stress |
| Biological Process | GO:0009410 | response to xenobiotic stimulus |
| Biological Process | GO:0031295 | T cell costimulation |
Reference
[1] Sheng L, Xu H, Wang Y, Ni J, Xiang T et al.. Systematic analysis of lysine lactylation in nucleus pulposus cells.. iScience 27(11):111157. 2024 Nov 15. PMID: 39524337.