Overview
| Uniprot ID | P11802 |
|---|
| Protein Name | Cyclin-dependent kinase 4 |
|---|
| Gene Name | CDK4 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 225 |
SEADQLGKIFDLIGL |
Function
Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and represses its transcriptional activity. Component of the ternary complex, cyclin D/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex
Protein Sequence
10
MATSRYEPVA
20
EIGVGAYGTV
30
YKARDPHSGH
40
FVALKSVRVP
50
NGGGGGGGLP
60
ISTVREVALL
70
RRLEAFEHPN
80
VVRLMDVCAT
90
SRTDREIKVT
100
LVFEHVDQDL
110
RTYLDKAPPP
120
GLPAETIKDL
130
MRQFLRGLDF
140
LHANCIVHRD
150
LKPENILVTS
160
GGTVKLADFG
170
LARIYSYQMA
180
LTPVVVTLWY
190
RAPEVLLQST
200
YATPVDMWSV
210
GCIFAEMFRR
220
KPLFCGNSEA
230
DQLGKIFDLI
240
GLPPEDDWPR
250
DVSLPRGAFP
260
PRGPRPVQSV
270
VPEMEESGAQ
280
LLLEMLTFNP
290
HKRISAFRAL
300
QHSYLHKDEG
NPE
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005923 |
bicellular tight junction |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0097128 |
cyclin D1-CDK4 complex |
| Cellular Component |
GO:0097129 |
cyclin D2-CDK4 complex |
| Cellular Component |
GO:0000307 |
cyclin-dependent protein kinase holoenzyme complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0031965 |
nuclear membrane |
| Cellular Component |
GO:0005730 |
nucleolus |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0005667 |
transcription regulator complex |
| Molecular Function |
GO:0005524 |
ATP binding |
| Molecular Function |
GO:0030332 |
cyclin binding |
| Molecular Function |
GO:0004693 |
cyclin-dependent protein serine/threonine kinase activity |
| Molecular Function |
GO:0016538 |
cyclin-dependent protein serine/threonine kinase regulator activity |
| Molecular Function |
GO:0106310 |
protein serine kinase activity |
| Biological Process |
GO:0051301 |
cell division |
| Biological Process |
GO:0000082 |
G1/S transition of mitotic cell cycle |
| Biological Process |
GO:0000086 |
G2/M transition of mitotic cell cycle |
| Biological Process |
GO:0008284 |
positive regulation of cell population proliferation |
| Biological Process |
GO:0048146 |
positive regulation of fibroblast proliferation |
| Biological Process |
GO:0010971 |
positive regulation of G2/M transition of mitotic cell cycle |
| Biological Process |
GO:0051726 |
regulation of cell cycle |
| Biological Process |
GO:0010468 |
regulation of gene expression |
| Biological Process |
GO:0060260 |
regulation of transcription initiation by RNA polymerase II |
| Biological Process |
GO:0009410 |
response to xenobiotic stimulus |
| Biological Process |
GO:0007165 |
signal transduction |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.