Search Results
Overview
| Uniprot ID | P11908 |
|---|---|
| Protein Name | Ribose-phosphate pyrophosphokinase 2 |
| Gene Name | PRPS2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 176 | SPDAGGAKRVTSIAD |
| 194 | VEFALIHKERKKANE |
| 235 | TICHAADKLLSAGAT |
Function
Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis
Protein Sequence
10
MPNIVLFSGS
20
SHQDLSQRVA
30
DRLGLELGKV
40
VTKKFSNQET
50
SVEIGESVRG
60
EDVYIIQSGC
70
GEINDNLMEL
80
LIMINACKIA
90
SSSRVTAVIP
100
CFPYARQDKK
110
DKSRAPISAK
120
LVANMLSVAG
130
ADHIITMDLH
140
ASQIQGFFDI
150
PVDNLYAEPA
160
VLQWIRENIA
170
EWKNCIIVSP
180
DAGGAKRVTS
190
IADRLNVEFA
200
LIHKERKKAN
210
EVDRMVLVGD
220
VKDRVAILVD
230
DMADTCGTIC
240
HAADKLLSAG
250
ATKVYAILTH
260
GIFSGPAISR
270
INNAAFEAVV
280
VTNTIPQEDK
290
MKHCTKIQVI
300
DISMILAEAI
310
RRTHNGESVS
YLFSHVPL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005737 | cytoplasm |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0016301 | kinase activity |
| Molecular Function | GO:0000287 | magnesium ion binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0004749 | ribose phosphate diphosphokinase activity |
| Biological Process | GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process |
| Biological Process | GO:0006139 | nucleobase-containing compound metabolic process |
| Biological Process | GO:0006098 | pentose-phosphate shunt |
| Biological Process | GO:0006164 | purine nucleotide biosynthetic process |
| Biological Process | GO:0009156 | ribonucleoside monophosphate biosynthetic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.