Search Results

Overview

Uniprot ID	P12007
Protein Name	Isovaleryl-CoA dehydrogenase, mitochondrial
Gene Name	Ivd
Organism	Rattus norvegicus

Kla Sites from experimental identification

Position	Flanking peptide
239	MPGFSTSKKLDKLGM
56	QLRHTISKFVQENLA
76	IDQSNDFKNLREFWK

Function

A mitochondrial matrix enzyme that catalyzes the third step in leucine catabolism, where isovaleryl-CoA (3-methylbutanoyl-CoA) is metabolized to 3-methylbut-2-enoyl-CoA. To a lesser extent, it also participates in the first step in fatty acid beta-oxidation, in which it catalyzes the proR-proR stereospecific alpha,beta-dehydrogenation of other saturated short-chain acyl-CoA thioesters such as pentanoyl-CoA, hexanoyl-CoA and butanoyl-CoA, using the electron transfer flavoprotein (ETF) as their physiologic electron acceptor

Protein Sequence

10 MATAVRLLGR 20 RVSSWRLRPL 30 PSPLAVPQRA 40 HSMLPVDDDI 50 NGLNEEQKQL 60 RHTISKFVQE 70 NLAPKAQEID 80 QSNDFKNLRE 90 FWKQLGSLGV 100 LGITAPVQYG 110 GSGLGYLEHV 120 LVMEEISRAS 130 AAVGLSYGAH 140 SNLCINQIVR 150 NGNEAQKEKY 160 LPKLISGEFI 170 GALAMSEPNA 180 GSDVVSMRLK 190 AEKKGDHYVL 200 NGNKFWITNG 210 PDADVLVVYA 220 KTDLTAVPAS 230 RGITAFIVEK 240 DMPGFSTSKK 250 LDKLGMRGSN 260 TCELVFEDCK 270 VPAANILSQE 280 SKGVYVLMSG 290 LDLERLVLAG 300 GPLGIMQAVL 310 DHTIPYLHVR 320 EAFGQKIGQF 330 QLMQGKMADM 340 YTRLMACRQY 350 VYNVARACDE 360 GHITAKDCAG 370 VILYTAECAT 380 QVALDGIQCL 390 GGNGYINDFP 400 MGRFLRDAKL 410 YEIGGGTSEV 420 RRLVIGRAFN ADFR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0031966	mitochondrial membrane
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0008470	3-methylbutanoyl-CoA dehydrogenase activity
Molecular Function	GO:0050660	flavin adenine dinucleotide binding
Molecular Function	GO:0042802	identical protein binding
Biological Process	GO:0009083	branched-chain amino acid catabolic process
Biological Process	GO:0033539	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Biological Process	GO:0006552	L-leucine catabolic process
Biological Process	GO:0006551	L-leucine metabolic process

Reference

[1] Yao Y, Bade R, Li G, Zhang A, Zhao H et al.. Global-Scale Profiling of Differential Expressed Lysine-Lactylated Proteins in the Cerebral Endothelium of Cerebral Ischemia-Reperfusion Injury Rats.. Cell Mol Neurobiol 43(5):1989-2004. 2023 Jul. PMID: 36030297.

[2] Chen Y, Sun W, Sun Z, Zhao H, Wu T et al.. Effect of electroacupuncture on hippocampal protein lactylation in a rat model of vascular dementia.. Front Neurol 16:1629474. 2025. PMID: 40963935.