Search Results

Overview

Uniprot IDP12036
Protein NameNeurofilament heavy polypeptide
Gene NameNEFH
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
114 RFAGYIDKVRQLEAH
219 ARVDLQKKAQALQEE
336 TTELEALKSTKDSLE
786 DKFPEKAKSPVKEEV

Function

Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)

Protein Sequence

10 MMSFGGADAL 20 LGAPFAPLHG 30 GGSLHYALAR 40 KGGAGGTRSA 50 AGSSSGFHSW 60 TRTSVSSVSA 70 SPSRFRGAGA 80 ASSTDSLDTL 90 SNGPEGCMVA 100 VATSRSEKEQ 110 LQALNDRFAG 120 YIDKVRQLEA 130 HNRSLEGEAA 140 ALRQQQAGRS 150 AMGELYEREV 160 REMRGAVLRL 170 GAARGQLRLE 180 QEHLLEDIAH 190 VRQRLDDEAR 200 QREEAEAAAR 210 ALARFAQEAE 220 AARVDLQKKA 230 QALQEECGYL 240 RRHHQEEVGE 250 LLGQIQGSGA 260 AQAQMQAETR 270 DALKCDVTSA 280 LREIRAQLEG 290 HAVQSTLQSE 300 EWFRVRLDRL 310 SEAAKVNTDA 320 MRSAQEEITE 330 YRRQLQARTT 340 ELEALKSTKD 350 SLERQRSELE 360 DRHQADIASY 370 QEAIQQLDAE 380 LRNTKWEMAA 390 QLREYQDLLN 400 VKMALDIEIA 410 AYRKLLEGEE 420 CRIGFGPIPF 430 SLPEGLPKIP 440 SVSTHIKVKS 450 EEKIKVVEKS 460 EKETVIVEEQ 470 TEETQVTEEV 480 TEEEEKEAKE 490 EEGKEEEGGE 500 EEEAEGGEEE 510 TKSPPAEEAA 520 SPEKEAKSPV 530 KEEAKSPAEA 540 KSPEKEEAKS 550 PAEVKSPEKA 560 KSPAKEEAKS 570 PPEAKSPEKE 580 EAKSPAEVKS 590 PEKAKSPAKE 600 EAKSPAEAKS 610 PEKAKSPVKE 620 EAKSPAEAKS 630 PVKEEAKSPA 640 EVKSPEKAKS 650 PTKEEAKSPE 660 KAKSPEKEEA 670 KSPEKAKSPV 680 KAEAKSPEKA 690 KSPVKAEAKS 700 PEKAKSPVKE 710 EAKSPEKAKS 720 PVKEEAKSPE 730 KAKSPVKEEA 740 KTPEKAKSPV 750 KEEAKSPEKA 760 KSPEKAKTLD 770 VKSPEAKTPA 780 KEEARSPADK 790 FPEKAKSPVK 800 EEVKSPEKAK 810 SPLKEDAKAP 820 EKEIPKKEEV 830 KSPVKEEEKP 840 QEVKVKEPPK 850 KAEEEKAPAT 860 PKTEEKKDSK 870 KEEAPKKEAP 880 KPKVEEKKEP 890 AVEKPKESKV 900 EAKKEEAEDK 910 KKVPTPEKEA 920 PAKVEVKEDA 930 KPKEKTEVAK 940 KEPDDAKAKE 950 PSKPAEKKEA 960 APEKKDTKEE 970 KAKKPEEKPK 980 TEAKAKEDDK 990 TLSKEPSKPK 1000 AEKAEKSSST 1010 DQKDSKPPEK 1020 ATEDKAAKGK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030424 axon
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0097418 neurofibrillary tangle
Cellular Component GO:0005883 neurofilament
Cellular Component GO:0014069 postsynaptic density
Cellular Component GO:0099160 postsynaptic intermediate filament cytoskeleton
Cellular Component GO:0098685 Schaffer collateral - CA1 synapse
Molecular Function GO:0070840 dynein complex binding
Molecular Function GO:0019894 kinesin binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0019901 protein kinase binding
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Molecular Function GO:0005200 structural constituent of cytoskeleton
Molecular Function GO:0099184 structural constituent of postsynaptic intermediate filament cytoskeleton
Biological Process GO:0061564 axon development
Biological Process GO:0007409 axonogenesis
Biological Process GO:0030031 cell projection assembly
Biological Process GO:0045110 intermediate filament bundle assembly
Biological Process GO:0033693 neurofilament bundle assembly
Biological Process GO:0099170 postsynaptic modulation of chemical synaptic transmission
Biological Process GO:1902513 regulation of organelle transport along microtubule

Reference

[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.